{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:06:35Z","timestamp":1789567595707,"version":"build-2803163510"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100001082","name":"Camille and Henry Dreyfus Foundation","doi-asserted-by":"publisher","award":["TC-21-092"],"award-info":[{"award-number":["TC-21-092"]}],"id":[{"id":"10.13039\/100001082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM148184"],"award-info":[{"award-number":["GM148184"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM159580"],"award-info":[{"award-number":["T32GM159580"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Macrolide antibiotics are a class of structurally diverse polyketides including essential medicines like erythromycin and azithromycin. Structurally minimal macrolides such as narbomycin lack much of the functionality common to other members of the class and exhibit a distinct mode of action wherein they completely inhibit bacterial growth despite only moderate inhibition of global protein synthesis. Unfortunately, lack of availability of these natural products has prevented a thorough investigation of their unusual mechanisms of action. Here we report a 10-step synthesis of narbomycin enabled by a Liebeskind-Srogl fragment coupling, a novel macrolactonization by direct displacement of an Evans auxiliary, and a stereoselective late-stage enone reduction. In addition to accessing the natural product, the route enables access to C8,19-unsaturated variants which could in principle serve as useful precursors for late-stage functionalization by conjugate addition.<\/jats:p>","DOI":"10.1021\/jacs.6c12688","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:52:41Z","timestamp":1788249161000},"page":"38582-38587","source":"Crossref","is-referenced-by-count":0,"title":["Convergent Synthesis\nof the Minimal Macrolide Antibiotic\nNarbomycin"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-0852","authenticated-orcid":true,"given":"Quinn","family":"Edmondson","sequence":"first","affiliation":[{"name":"University of California, San Francisco , , , ,","place":["San Francisco, California, United States, 94158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1709-4078","authenticated-orcid":true,"given":"Cecilia","family":"Panfil","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute , , , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine K.","family":"Keyes","sequence":"additional","affiliation":[{"name":"University of California, San Francisco , , , ,","place":["San Francisco, California, United States, 94158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-0825","authenticated-orcid":true,"given":"Andrew K.","family":"Ecker","sequence":"additional","affiliation":[{"name":"University of California, San Francisco , , , ,","place":["San Francisco, California, United States, 94158"]},{"name":"The Scripps Research Institute , , , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-454X","authenticated-orcid":true,"given":"Nicholas S.","family":"Settineri","sequence":"additional","affiliation":[{"name":"Lawrence Berkeley National Laboratory , , , ,","place":["Berkeley, California, United States, 94720"]},{"name":"University of California , , , ,","place":["Berkeley, California, United States, 94720"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-1362","authenticated-orcid":true,"given":"Ian B.","family":"Seiple","sequence":"additional","affiliation":[{"name":"University of California, San Francisco , , , ,","place":["San Francisco, California, United States, 94158"]},{"name":"The Scripps Research Institute , , , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"2","key":"2026091609124604700_cit1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1021\/cr030107f","article-title":"Translation and\nProtein Synthesis: Macrolides","volume":"105","author":"Katz","year":"2005","journal-title":"Chem. Rev."},{"issue":"1","key":"2026091609124604700_cit2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrmicro3155","article-title":"Ribosome-Targeting\nAntibiotics and Mechanisms of Bacterial Resistance","volume":"12","author":"Wilson","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"issue":"45","key":"2026091609124604700_cit3","doi-asserted-by":"publisher","first-page":"15958","DOI":"10.1073\/pnas.1417334111","article-title":"The General\nMode of Translation Inhibition by Macrolide Antibiotics","volume":"111","author":"Kannan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"2026091609124604700_cit4","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/hlca.19550380412","article-title":"Stoffwechselprodukte von Actinomyceten. 1. Mitteilung.\nNarbomycin","volume":"38","author":"Corbaz","year":"1955","journal-title":"Helv. Chim. Acta"},{"issue":"6","key":"2026091609124604700_cit5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/BF00638597","article-title":"Pikromycin, ein neues\nAntibiotikum aus Actinomyceten","volume":"37","author":"Brockmann","year":"1950","journal-title":"Naturwissenschaften"},{"issue":"4","key":"2026091609124604700_cit6","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.diagmicrobio.2009.10.013","article-title":"CEM-101,\na Novel Fluoroketolide: Antimicrobial Activity against a Diverse Collection\nof Gram-Positive and Gram-Negative Bacteria","volume":"66","author":"Putnam","year":"2010","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"16","key":"2026091609124604700_cit7","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.1093\/nar\/gkx673","article-title":"Co-Produced Natural Ketolides Methymycin\nand Pikromycin Inhibit Bacterial Growth by Preventing Synthesis of\na Limited Number of Proteins","volume":"45","author":"Almutairi","year":"2017","journal-title":"Nucleic Acids\nRes."},{"issue":"3","key":"2026091609124604700_cit8","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s00253-011-3592-9","article-title":"Engineered\nBiosynthesis of Glycosylated Derivatives of Narbomycin and Evaluation\nof Their Antibacterial Activities","volume":"93","author":"Han","year":"2012","journal-title":"Appl. Microbiol.\nBiotechnol."},{"issue":"7603","key":"2026091609124604700_cit9","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nature17967","article-title":"A Platform for the Discovery of New Macrolide Antibiotics","volume":"533","author":"Seiple","year":"2016","journal-title":"Nature"},{"issue":"7","key":"2026091609124604700_cit10","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1021\/acs.accounts.1c00020","article-title":"Discovery of Macrolide\nAntibiotics Effective against\nMulti-Drug Resistant Gram-Negative Pathogens","volume":"54","author":"Myers","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"26","key":"2026091609124604700_cit11","doi-asserted-by":"publisher","first-page":"10496","DOI":"10.1073\/pnas.1103474108","article-title":"Role of Antibiotic Ligand in Nascent\nPeptide-Dependent Ribosome Stalling","volume":"108","author":"Va\u0301zquez-Laslop","year":"2011","journal-title":"Proc. Natl.\nAcad. Sci. U. S. A."},{"issue":"2","key":"2026091609124604700_cit12","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1021\/jo201158q","article-title":"Total Synthesis\nof Pikromycin","volume":"77","author":"Oh","year":"2012","journal-title":"J. Org. Chem."},{"issue":"4","key":"2026091609124604700_cit13","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1021\/jo702384d","article-title":"Total Synthesis\nof 10-Deoxymethynolide and Narbonolide","volume":"73","author":"Xuan","year":"2008","journal-title":"J. Org.\nChem."},{"issue":"8","key":"2026091609124604700_cit14","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1021\/jo00347a061","article-title":"Macrolide Synthesis: Narbonolide","volume":"47","author":"Kaiho","year":"1982","journal-title":"J. Org. Chem."},{"issue":"18","key":"2026091609124604700_cit15","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.1021\/jo050924a","article-title":"Formal Total Synthesis\nof the Polyketide Macrolactone Narbonolide","volume":"70","author":"Venkatraman","year":"2005","journal-title":"J. Org. Chem."},{"issue":"6","key":"2026091609124604700_cit16","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1248\/cpb.35.2228","article-title":"Highly Stereoselective\nTotal Synthesis of Pikronolide, the Aglycon of the First Macrolide\nAntibiotic Pikromycin. Crucial Role of Benzyl-Type Protecting Groups\nRemovable by 2, 4-Dichloro-5, 6-Dicyanobenzoquinone Oxidation","volume":"35","author":"Nakajima","year":"1987","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"15","key":"2026091609124604700_cit17","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.1021\/ja00275a063","article-title":"Chiral Synthesis\nof Polyketide-Derived Natural Products. 10. Stereoselective Synthesis\nof Pikronolide, the Aglycon of the 14-Membered Ring Macrolide Pikromycin,\nfrom D-Glucose. Role of MPM and DMPM Protection","volume":"108","author":"Nakajima","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"2026091609124604700_cit18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3987\/COM-97-S38","article-title":"An Alternative\nand Facile Synthesis\nof Pikronolide","volume":"46","author":"Nakajima","year":"1997","journal-title":"Heterocycles"},{"issue":"24","key":"2026091609124604700_cit19","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1016\/j.tet.2010.04.039","article-title":"Total Synthesis\nof Neomethymycin and Novamethymycin","volume":"66","author":"Oh","year":"2010","journal-title":"Tetrahedron"},{"issue":"21","key":"2026091609124604700_cit20","doi-asserted-by":"publisher","first-page":"8286","DOI":"10.1021\/ja00203a044","article-title":"A New, Highly Efficient, Selective\nMethodology for Formation of Medium-Ring and Macrocyclic Lactones\nvia Intramolecular Ketene Trapping: An Application to a Convergent\nSynthesis of (\u2212)-Kromycin","volume":"111","author":"Boeckman","year":"1989","journal-title":"J. Am. Chem.\nSoc."},{"issue":"26","key":"2026091609124604700_cit21","doi-asserted-by":"publisher","first-page":"5486","DOI":"10.1021\/jo00376a101","article-title":"Studies Directed toward the Synthesis\nof Naturally Occurring Acyltetramic Acids. 2. Preparation of the Macrocyclic\nSubunit of Ikarugamycin","volume":"51","author":"Boeckman","year":"1986","journal-title":"J. Org. Chem."},{"issue":"26","key":"2026091609124604700_cit22","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1021\/jo00200a018","article-title":"Ketenes. 20. Thermal Decomposition\nof 2,2,6-Trimethyl-4H-1,3-Dioxin-4-One and 1-Ethoxybutyn-3-One. Acetylketene","volume":"49","author":"Hyatt","year":"1984","journal-title":"J. Org. Chem."},{"issue":"11","key":"2026091609124604700_cit23","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1039\/b912599j","article-title":"Bond Formations\nby Intermolecular\nand Intramolecular Trappings of Acylketenes and Their Applications\nin Natural Product Synthesis","volume":"38","author":"Reber","year":"2009","journal-title":"Chem. Soc. Rev."},{"issue":"4","key":"2026091609124604700_cit24","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1021\/ja00316a077","article-title":"Asymmetric\nAcylation Reactions of Chiral Imide Enolates. The First Direct Approach\nto the Construction of Chiral.Beta.-Dicarbonyl Synthons","volume":"106","author":"Evans","year":"1984","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"2026091609124604700_cit25","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.1021\/ja9806128","article-title":"General Strategies\ntoward the Syntheses of Macrolide Antibiotics. The Total Syntheses\nof 6-Deoxyerythronolide B and Oleandolide","volume":"120","author":"Evans","year":"1998","journal-title":"J.\nAm. Chem. Soc."},{"issue":"7","key":"2026091609124604700_cit26","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1021\/ja01382a016","article-title":"THE KETONIC\nDECOMPOSITION OF BETA-KETO CARBOXYLIC ACIDS","volume":"51","author":"Pedersen","year":"1929","journal-title":"J. Am. Chem. Soc."},{"issue":"18","key":"2026091609124604700_cit27","doi-asserted-by":"publisher","first-page":"6346","DOI":"10.1021\/jo960356m","article-title":"Electronic Factors\nInfluencing the Decarboxylation\nof \u03b2-Keto Acids. A Model Enzyme Study","volume":"61","author":"Bach","year":"1996","journal-title":"J. Org. Chem."},{"issue":"6","key":"2026091609124604700_cit28","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1021\/acs.jpcc.0c10797","article-title":"Alkyl Substituted\nBeta-Keto Acids: Molecular Structure and Decarboxylation Kinetics\nin Aqueous Solution and on the Surface of Metal Oxides","volume":"125","author":"Ignatchenko","year":"2021","journal-title":"J. Phys. Chem. C"},{"issue":"11","key":"2026091609124604700_cit29","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1021\/ja00401a051","article-title":"Asymmetric Total\nSynthesis of Erythromycin. 3. Total\nSynthesis of Erythromycin","volume":"103","author":"Woodward","year":"1981","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"2026091609124604700_cit30","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1002\/anie.201507357","article-title":"Synthesis of D-Desosamine and Analogs\nby Rapid Assembly of 3-Amino Sugars","volume":"55","author":"Zhang","year":"2016","journal-title":"Angew.\nChem., Int. Ed."},{"issue":"26","key":"2026091609124604700_cit31","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1016\/j.tetlet.2009.03.013","article-title":"Enantioselective Synthesis of Polyketide Segments through\nVinylogous Mukaiyama Aldol Reactions","volume":"50","author":"Simsek","year":"2009","journal-title":"Tetrahedron\nLett."},{"issue":"19","key":"2026091609124604700_cit32","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1021\/ol8018456","article-title":"Synthesis of High Enantiopurity N-Protected\n\u03b1-Amino Ketones by Thiol Ester\u2013Organostannane Cross-Coupling\nUsing pH-Neutral Conditions","volume":"10","author":"Li","year":"2008","journal-title":"Org. Lett."},{"issue":"20","key":"2026091609124604700_cit33","doi-asserted-by":"publisher","first-page":"5905","DOI":"10.1021\/jo00099a018","article-title":"On the\nNature of the \u201cCopper Effect\u201d in the Stille Cross-Coupling","volume":"59","author":"Farina","year":"1994","journal-title":"J. Org. Chem."},{"issue":"35","key":"2026091609124604700_cit34","doi-asserted-by":"publisher","first-page":"11148","DOI":"10.1021\/jacs.6b07846","article-title":"Enantioselective\nSynthesis of (+)-Peganumine\nA","volume":"138","author":"Piemontesi","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"2026091609124604700_cit35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1351\/pac197128040413","article-title":"Stereochemical\nProblems in Macrolide Antibiotics","volume":"28","author":"Celmer","year":"1971","journal-title":"Pure Appl.\nChem."},{"issue":"17","key":"2026091609124604700_cit36","doi-asserted-by":"publisher","first-page":"5098","DOI":"10.1021\/acs.orglett.8b01896","article-title":"Broadly Applicable\nYtterbium-Catalyzed Esterification, Hydrolysis, and Amidation of Imides","volume":"20","author":"Guissart","year":"2018","journal-title":"Org. Lett."},{"issue":"35","key":"2026091609124604700_cit37","doi-asserted-by":"publisher","first-page":"15116","DOI":"10.1021\/jacs.0c06648","article-title":"Modular Approaches to Lankacidin\nAntibiotics","volume":"142","author":"Cai","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"2026091609124604700_cit38","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1021\/jo00005a013","article-title":"Transacetoacetylation with Tert-Butyl Acetoacetate:\nSynthetic Applications","volume":"56","author":"Witzeman","year":"1991","journal-title":"J. Org. Chem."},{"issue":"24","key":"2026091609124604700_cit39","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.tetlet.2017.03.088","article-title":"4Z- and 4E-12-Deoxydihydrokromycins,\nTwo Naturally Occurring Kromycin Aglycones of Pikromycin from Streptomyces Sp","volume":"58","author":"Yang","year":"2017","journal-title":"Tetrahedron Lett."},{"key":"2026091609124604700_cit40","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1039\/c39750000209","article-title":"A Steroid Hydroxylase Inhibitor, Diplodialide A from Diplodia Pinea","volume":"6","author":"Ishida","year":"1975","journal-title":"J. Chem. Soc. Chem. Commun."},{"issue":"4","key":"2026091609124604700_cit41","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/cber.19570900425","article-title":"Antibiotica aus Actinomyceten,\nXXXVIII. Zur Konstitution des Pikromycins\nund Kromycins (Pikromycin, VI)","volume":"90","author":"Brockmann","year":"1957","journal-title":"Chem. Ber."},{"issue":"4","key":"2026091609124604700_cit42","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1021\/cs200571v","article-title":"Rhodium-Catalyzed\nHydrosilylation of Ketones: Catalyst Development and Mechanistic Insights","volume":"2","author":"Riener","year":"2012","journal-title":"ACS Catal."},{"issue":"13","key":"2026091609124604700_cit43","doi-asserted-by":"publisher","first-page":"8552","DOI":"10.1021\/acs.joc.9b00959","article-title":"Theoretical Study on the Rhodium-Catalyzed Hydrosilylation\nof C\u2550C and C\u2550O Double Bonds with Tertiary Silane","volume":"84","author":"Zhao","year":"2019","journal-title":"J. Org. Chem."},{"issue":"49","key":"2026091609124604700_cit44","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.1016\/S0040-4039(01)85162-5","article-title":"Selective Reduction\nof \u03b1,\u03b2-Unsaturated\nTerpene Carbonyl Compounds Using Hydrosilane-Rhodium(I) Complex Combinations","volume":"13","author":"Ojima","year":"1972","journal-title":"Tetrahedron Lett."},{"issue":"26","key":"2026091609124604700_cit45","doi-asserted-by":"publisher","first-page":"10619","DOI":"10.1021\/jo051470k","article-title":"Total Synthesis\nof Guanacastepene A: A Route to Enantiomeric Control","volume":"70","author":"Mandal","year":"2005","journal-title":"J. Org. Chem."},{"issue":"18","key":"2026091609124604700_cit46","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1111\/bph.13936","article-title":"The Macrolide\nAntibiotic Renaissance","volume":"174","author":"Dinos","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"2026091609124604700_cit47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S1097-2765(02)00570-1","article-title":"The Structures of\nFour Macrolide Antibiotics Bound\nto the Large Ribosomal Subunit","volume":"10","author":"Hansen","year":"2002","journal-title":"Mol. Cell"},{"issue":"1","key":"2026091609124604700_cit48","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.1038\/s41467-021-24674-9","article-title":"Structural and Mechanistic\nBasis for Translation Inhibition by Macrolide and Ketolide Antibiotics","volume":"12","author":"Beckert","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"2026091609124604700_cit49","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1073\/pnas.1019406108","article-title":"Crystal Structure\nof the Synergistic Antibiotic Pair, Lankamycin and Lankacidin, in\nComplex with the Large Ribosomal Subunit","volume":"108","author":"Belousoff","year":"2011","journal-title":"Proc.\nNatl. Acad. Sci. U. S. A."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c12688","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/36\/38582\/67413007\/jacs.6c12688.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/36\/38582\/67413007\/jacs.6c12688.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:25:13Z","timestamp":1789565113000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/36\/38582\/5329333\/Convergent-Synthesis-of-the-Minimal-Macrolide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":49,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2026,8,26]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c12688","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.15005123\/v1","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}