{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:49:47Z","timestamp":1792003787098,"version":"4.4.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"Welch Research Foundation","doi-asserted-by":"publisher","award":["AT-1974-20180324"],"award-info":[{"award-number":["AT-1974-20180324"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Welch Research Foundation","doi-asserted-by":"publisher","award":["AT-2222-20240404"],"award-info":[{"award-number":["AT-2222-20240404"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK124881"],"award-info":[{"award-number":["R01DK124881"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Proximal tubules, with their unique microenvironment and specialized brush-border microvilli, actively reabsorb, metabolize, and process filtered molecular cargos, yet how they interact with renal-clearable nanomaterials after glomerular filtration remains poorly understood. Here, using reactive oxygen species (ROS)-responsive glutathione-coated Au11 nanoclusters (\u223c0.6 nm) as a model, we show that renal-filtered Au11 undergoes extracellular ROS-mediated biotransformation into 2\u20133 nm gold nanoparticles, followed by their assembly into large nanostructures (\u223c50\u2013500 nm) within the proximal tubular lumen of healthy kidneys. Unexpectedly, high-resolution electron microscopy revealed that brush-border microvilli capture these large luminal nanoassemblies, transport them from microvillar tips to the microvillar base, and internalize them through apical pinching-off events. The internalized nanoassemblies subsequently traffic through apical vacuoles to lysosomes, where a second-stage biotransformation produces densely packed flower-like gold nanostructures that are ultimately re-eliminated into the tubular lumen through membrane extrusion. These findings demonstrate that extracellular ROS (\u223c10 \u03bcM) under physiological conditions could substantially transform renal-filtered nanomaterials and reveal an unrecognized function of proximal tubular microvilli in transporting and internalizing large luminal nanoassemblies.<\/jats:p>","DOI":"10.1021\/jacs.6c13282","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:02:00Z","timestamp":1790701320000},"page":"43443-43452","source":"Crossref","is-referenced-by-count":0,"title":["Microvilli-Mediated\nTransport and Internalization\nof Extracellularly Assembled Nanoparticles in Kidney Proximal Tubules"],"prefix":"10.1021","volume":"148","author":[{"given":"Samira","family":"Ahrari","sequence":"first","affiliation":[{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiao","family":"Yu","sequence":"additional","affiliation":[{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]},{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arefeh","family":"Shafie","sequence":"additional","affiliation":[{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Ning","sequence":"additional","affiliation":[{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-1882","authenticated-orcid":true,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]},{"name":"The University of Texas at Dallas , , 800 W. Campbell Rd. , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"9","key":"2026101414100463000_cit1","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.2215\/CJN.10391012","article-title":"Proximal tubule\nfunction and response to acidosis","volume":"9","author":"Curthoys","year":"2014","journal-title":"Clin. J.\nAm. Soc. Nephrol."},{"key":"2026101414100463000_cit2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-physiol-022516-034234","article-title":"Receptor-mediated endocytosis in the proximal tubule","volume":"79","author":"Eshbach","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"2026101414100463000_cit3","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1002\/cphy.cp080248","article-title":"Renal excretion\nand tubular transport of organic anions and cations","volume-title":"Handbook of Physiology","author":"Roch-Ramel","year":"1992"},{"issue":"4","key":"2026101414100463000_cit4","doi-asserted-by":"publisher","first-page":"R851","DOI":"10.1152\/ajpregu.00002.2010","article-title":"Mechanisms\nof proximal tubule sodium transport regulation that link extracellular\nfluid volume and blood pressure","volume":"298","author":"McDonough","year":"2010","journal-title":"Am. J. Physiol.:\nRegul., Integr. Comp. Physiol."},{"issue":"14","key":"2026101414100463000_cit5","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1113\/JP281599","article-title":"Endocytic\nadaptation to functional demand by the kidney proximal tubule","volume":"599","author":"Weisz","year":"2021","journal-title":"J. Physiol."},{"issue":"4","key":"2026101414100463000_cit6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1152\/physiol.00022.2012","article-title":"Endocytic\nreceptors in the renal proximal tubule","volume":"27","author":"Christensen","year":"2012","journal-title":"Physiology"},{"issue":"3","key":"2026101414100463000_cit7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3390\/membranes4030333","article-title":"The endocytic receptor megalin and\nits associated proteins in proximal tubule epithelial cells","volume":"4","author":"De","year":"2014","journal-title":"Membranes"},{"issue":"10","key":"2026101414100463000_cit8","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/nbt1340","article-title":"Renal clearance of quantum dots","volume":"25","author":"Choi","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"260","key":"2026101414100463000_cit9","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009524","article-title":"Clinical translation of an ultrasmall inorganic optical-PET\nimaging nanoparticle probe","volume":"6","author":"Phillips","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"14","key":"2026101414100463000_cit10","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1002\/anie.201007321","article-title":"Luminescent\nGold Nanoparticles with Efficient Renal Clearance","volume":"50","author":"Zhou","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"issue":"39","key":"2026101414100463000_cit11","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1002\/adma.201402964","article-title":"Gd-Encapsulated\nCarbonaceous Dots with Efficient Renal Clearance for Magnetic Resonance\nImaging","volume":"26","author":"Chen","year":"2014","journal-title":"Adv. Mater."},{"issue":"33","key":"2026101414100463000_cit12","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1039\/C4TB00811A","article-title":"Facile non-hydrothermal synthesis\nof oligosaccharides coated sub-5\nnm magnetic iron oxide nanoparticles with dual MRI contrast enhancement\neffect","volume":"2","author":"Huang","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"11","key":"2026101414100463000_cit13","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/nnano.2017.170","article-title":"Glomerular barrier behaves as an atomically precise\nbandpass filter in a sub-nanometre regime","volume":"12","author":"Du","year":"2017","journal-title":"Nat.\nNanotechnol."},{"issue":"10","key":"2026101414100463000_cit14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s41578-018-0038-3","article-title":"Transport and interactions of nanoparticles in the\nkidneys","volume":"3","author":"Du","year":"2018","journal-title":"Nat. Rev. Mater."},{"issue":"7","key":"2026101414100463000_cit15","doi-asserted-by":"publisher","first-page":"6655","DOI":"10.1021\/acsnano.5b01320","article-title":"Clearance pathways\nand tumor targeting of imaging nanoparticles","volume":"9","author":"Yu","year":"2015","journal-title":"ACS Nano"},{"issue":"1","key":"2026101414100463000_cit16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nnano.2009.314","article-title":"Design considerations for tumour-targeted nanoparticles","volume":"5","author":"Choi","year":"2010","journal-title":"Nat. Nanotechnol."},{"issue":"13","key":"2026101414100463000_cit17","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1021\/ja401612x","article-title":"Passive Tumor Targeting\nof Renal-Clearable Luminescent Gold Nanoparticles:\nLong Tumor Retention and Fast Normal Tissue Clearance","volume":"135","author":"Liu","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"2026101414100463000_cit18","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s41563-022-01224-2","article-title":"Renal clearable\npolyfluorophore nanosensors\nfor early diagnosis of cancer and allograft rejection","volume":"21","author":"Huang","year":"2022","journal-title":"Nat. Mater."},{"issue":"8","key":"2026101414100463000_cit19","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1002\/anie.201511148","article-title":"Noninvasive\nStaging of Kidney Dysfunction Enabled by Renal-Clearable Luminescent\nGold Nanoparticles","volume":"55","author":"Yu","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"issue":"10","key":"2026101414100463000_cit20","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/s41563-019-0378-4","article-title":"Molecular optical imaging\nprobes for early diagnosis of drug-induced acute kidney injury","volume":"18","author":"Huang","year":"2019","journal-title":"Nat. Mater."},{"issue":"36","key":"2026101414100463000_cit21","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402479","article-title":"Gold Nanoparticle Transport\nin the Injured Kidneys with Elevated Renal Function Biomarkers","volume":"36","author":"Ning","year":"2024","journal-title":"Adv. Mater."},{"issue":"8","key":"2026101414100463000_cit22","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1021\/acs.bioconjchem.4c00312","article-title":"Early detection and noninvasive staging of kidney dysfunction by\na PEGylated conventional fluorophore via GFR-sensitive renal transport","volume":"35","author":"Peng","year":"2024","journal-title":"Bioconjugate Chem."},{"issue":"34","key":"2026101414100463000_cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202509978","article-title":"Blood Retention\nand Kidney Clearance of Renal-Clearable\nGold Nanoparticles Strongly Correlate with Renal Injury Biomarkers","volume":"64","author":"Ahrari","year":"2025","journal-title":"Angew. Chem., Int. 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Ed."},{"issue":"6","key":"2026101414100463000_cit27","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201905899","article-title":"Renal Clearable Theranostic Nanoplatforms for Gastrointestinal\nStromal Tumors","volume":"32","author":"Kang","year":"2020","journal-title":"Adv. Mater."},{"issue":"12","key":"2026101414100463000_cit28","doi-asserted-by":"publisher","first-page":"20021","DOI":"10.1021\/acsnano.2c05342","article-title":"Ultrasmall\nFolate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle\nDrug Conjugates Augment Penetration and Therapeutic Efficacy in Models\nof Cancer","volume":"16","author":"Wu","year":"2022","journal-title":"ACS Nano"},{"key":"2026101414100463000_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102245","article-title":"Renal-clearable\nluminescent gold nanoparticles incorporating\nactive and bio-orthogonal tumor-targeting for drug delivery and controlled\nrelease","volume":"56","author":"He","year":"2024","journal-title":"Nano Today"},{"issue":"2","key":"2026101414100463000_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201500223","article-title":"Biodegradable\nand renal clearable\ninorganic nanoparticles","volume":"3","author":"Ehlerding","year":"2016","journal-title":"Adv. Sci."},{"issue":"6","key":"2026101414100463000_cit31","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41581-024-00819-z","article-title":"Physiological\nprinciples\nunderlying the kidney targeting of renal nanomedicines","volume":"20","author":"Huang","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"23","key":"2026101414100463000_cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2403131121","article-title":"Charge barriers\nin the kidney elimination of engineered\nnanoparticles","volume":"121","author":"Huang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"38","key":"2026101414100463000_cit33","doi-asserted-by":"publisher","first-page":"34823","DOI":"10.1021\/jacs.5c10759","article-title":"pH-Responsive\nSelf-Assembly of Renal-Clearable\nNanoparticles in the Kidneys: One Assembly per Endosome","volume":"147","author":"Huang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"2026101414100463000_cit34","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41565-023-01366-7","article-title":"Proximal tubules\neliminate endocytosed gold nanoparticles\nthrough an organelle-extrusion-mediated self-renewal mechanism","volume":"18","author":"Huang","year":"2023","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"2026101414100463000_cit35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1161\/HYPERTENSIONAHA.117.09843","article-title":"Selective\nNanoparticle Targeting\nof the Renal Tubules","volume":"71","author":"Williams","year":"2018","journal-title":"Hypertension"},{"issue":"1","key":"2026101414100463000_cit36","doi-asserted-by":"publisher","first-page":"p1","DOI":"10.1159\/000096860","article-title":"The not so \u2018mighty\nchondrion\u2019: emergence\nof renal diseases due to mitochondrial dysfunction","volume":"105","author":"Hall","year":"2006","journal-title":"Nephron Physiol."},{"issue":"10","key":"2026101414100463000_cit37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial\nenergetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"17","key":"2026101414100463000_cit38","doi-asserted-by":"publisher","first-page":"7727","DOI":"10.1021\/jp9122584","article-title":"Luminescent Gold Nanoparticles with Mixed Valence States Generated\nfrom Dissociation of Polymeric Au(I) Thiolates","volume":"114","author":"Zhou","year":"2010","journal-title":"J. Phys. Chem. C"},{"issue":"7","key":"2026101414100463000_cit39","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1021\/ic8024588","article-title":"From superatomic Au25\n(SR) 18\u2013 to superatomic M@ Au24 (SR)\n18 q core\u2013 shell clusters","volume":"48","author":"Jiang","year":"2009","journal-title":"Inorg. Chem."},{"issue":"33","key":"2026101414100463000_cit40","doi-asserted-by":"publisher","first-page":"10833","DOI":"10.1021\/jacs.5b06946","article-title":"Interconversion\nbetween superatomic 6-electron and 8-electron configurations of M@\nAu24 (SR) 18 clusters (M= Pd, Pt)","volume":"137","author":"Kwak","year":"2015","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026101414100463000_cit41","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide\nas a central redox signaling molecule in physiological oxidative stress:\nOxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"issue":"2","key":"2026101414100463000_cit42","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.coph.2007.12.012","article-title":"Hydrogen peroxide as\nan endogenous mediator and exogenous tool in\ncardiovascular research: issues and considerations","volume":"8","author":"Schro\u0308der","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"2026101414100463000_cit43","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9512807","article-title":"Hydrogen peroxide\nand sodium transport\nin the lung and kidney","volume":"2016","author":"Shlyonsky","year":"2016","journal-title":"BioMed. Res. Int."},{"issue":"6","key":"2026101414100463000_cit44","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nchem.1352","article-title":"The gold\u2013sulfur\ninterface at the nanoscale","volume":"4","author":"Ha\u0308kkinen","year":"2012","journal-title":"Nat. Chem."},{"issue":"5","key":"2026101414100463000_cit45","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1039\/C4NR05794E","article-title":"Atomically\nprecise metal nanoclusters: stable sizes and optical properties","volume":"7","author":"Jin","year":"2015","journal-title":"Nanoscale"},{"issue":"9","key":"2026101414100463000_cit46","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1021\/ar200331z","article-title":"Quantum sized gold nanoclusters with\natomic precision","volume":"45","author":"Qian","year":"2012","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"2026101414100463000_cit47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/ki.2012.328","article-title":"In vivo\nmultiphoton imaging of mitochondrial structure and function during\nacute kidney injury","volume":"83","author":"Hall","year":"2013","journal-title":"Kidney Int."},{"key":"2026101414100463000_cit48","doi-asserted-by":"publisher","DOI":"10.1177\/1536012118820421","article-title":"A simple ex vivo semiquantitative\nfluorescent imaging utilizing planar laser scanner: detection of reactive\noxygen species generation in mouse brain and kidney","volume":"18","author":"Hosoi","year":"2019","journal-title":"Mol. Imaging"},{"issue":"6","key":"2026101414100463000_cit49","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1681\/ASN.2008070759","article-title":"Multiphoton\nimaging\nreveals differences in mitochondrial function between nephron segments","volume":"20","author":"Hall","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"2026101414100463000_cit50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/BF00215889","article-title":"Formation of apical\ntubules from large endocytic vacuoles in kidney proximal tubule cells\nduring absorption of horseradish peroxidase","volume":"246","author":"Hatae","year":"1986","journal-title":"Cell Tissue Res."},{"issue":"1","key":"2026101414100463000_cit51","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/0014-4827(62)90045-9","article-title":"Cytochemical\ninvestigation of phagosomes and related structures in cryostat sections\nof the kidney and liver of rats after intravenous administration of\nhorseradish peroxidase","volume":"27","author":"Straus","year":"1962","journal-title":"Exp. Cell Res."},{"issue":"6","key":"2026101414100463000_cit52","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1152\/ajplegacy.1973.225.6.1399","article-title":"Insulin uptake in the renal proximal\ntubule","volume":"225","author":"Bourdeau","year":"1973","journal-title":"Am. J. Physiol.-Legacy Content"},{"issue":"3-4","key":"2026101414100463000_cit53","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0022-5320(66)80108-9","article-title":"Absorption\nof I125-labeled homologous albumin by rat kidney proximal tubule cells:\nA study of microperfused single proximal tubules by electron microscopic\nautoradiography and histochemistry","volume":"15","author":"Maunsbach","year":"1966","journal-title":"J. Ultrastruct.\nRes."},{"issue":"1-2","key":"2026101414100463000_cit54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0022-5320(66)80028-X","article-title":"Hemoglobin absorption by proximal\ntubule cells of the\nrabbit kidney. A study by electron microscopic autoradiography","volume":"16","author":"Neustein","year":"1966","journal-title":"J. Ultrastruct. Res."},{"issue":"4","key":"2026101414100463000_cit55","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1177\/14.4.291","article-title":"Thf early\nstages of absorption of injected horseradish\nperoxidase in the proximal tubules of mouse kidney: ultrastructural\ncytochemistry by a new technique","volume":"14","author":"Graham","year":"1966","journal-title":"J. Histochem.\nCytochem."},{"issue":"2","key":"2026101414100463000_cit56","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1083\/jcb.54.2.382","article-title":"Serum albumin\nuptake in isolated\nperfused renal tubules: Quantitative and electron microscope radioautographic\nstudies in three anatomical segments of the rabbit nephron","volume":"54","author":"Bourdeau","year":"1972","journal-title":"J. Cell Biol."},{"issue":"1-2","key":"2026101414100463000_cit57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0022-5320(66)80019-9","article-title":"Absorption\nof ferritin by rat kidney proximal tubule cells: Electron microscopic\nobservations of the initial uptake phase in cells of microperfused\nsingle proximal tubules","volume":"16","author":"Maunsbach","year":"1966","journal-title":"J. Ultrastruct. Res."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c13282","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/40\/43443\/68701265\/jacs.6c13282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/40\/43443\/68701265\/jacs.6c13282.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:22:13Z","timestamp":1792002133000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/40\/43443\/5441749\/Microvilli-Mediated-Transport-and-Internalization"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":57,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2026,9,29]]},"published-print":{"date-parts":[[2026,10,14]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c13282","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}