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We report a general platform for C(sp3)\u2013C(sp3) cross-coupling enabled by the in situ formation and visible-light-induced denitrogenation of unsymmetric diazenes. Central to this approach is the development of N-benzoyloxysulfamides, which are readily prepared in a single step from primary amines and bench-stable O-benzoylhydroxylamines and undergo mild base-promoted conversion to diazenes. Subsequent photosensitized denitrogenation using an inexpensive organic triplet photosensitizer enables the direct union of two amine-derived fragments under operationally simple conditions. This telescoped, one-pot process avoids prefunctionalized organometallic reagents, tolerates a broad range of functional groups, and enables late-stage modification of complex molecules.<\/jats:p>","DOI":"10.1021\/jacs.6c13866","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:01:54Z","timestamp":1787014914000},"page":"36345-36351","source":"Crossref","is-referenced-by-count":0,"title":["General C(sp3)\u2013C(sp3)\nCross-Coupling of Primary Amines via in Situ Diazene Formation"],"prefix":"10.1021","volume":"148","author":[{"given":"Matthew C.","family":"Lamb","sequence":"first","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-3290","authenticated-orcid":true,"given":"Tristan H.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026090312084580800_cit1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nature19056","article-title":"Metallaphotoredox-Catalysed\nSp3\u2013Sp3 Cross-Coupling of Carboxylic\nAcids with Alkyl Halides","volume":"536","author":"Johnston","year":"2016","journal-title":"Nature"},{"key":"2026090312084580800_cit2","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1021\/cr0505268","article-title":"Selected Patented Cross-Coupling\nReaction Technologies","volume":"106","author":"Corbet","year":"2006","journal-title":"Chem. 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Development of an indazole derivative with improved\nvisible-light absorption while retaining high triplet energy represents\na promising avenue for future optimization."},{"key":"2026090312084580800_cit70","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1021\/ja00843a037","article-title":"Photochemical Rearrangements of Indazoles.\nTriplet Excited States of 1- and 2-Methylindazole","volume":"97","author":"Ferris","year":"1975","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312084580800_cit71","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1021\/ar020230d","article-title":"Bond Dissociation Energies of Organic Molecules","volume":"36","author":"Blanksby","year":"2003","journal-title":"Acc. Chem. 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