{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:07:27Z","timestamp":1789567647176,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012231","name":"Society of Memorial Sloan Kettering","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100012231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L016494\/1"],"award-info":[{"award-number":["EP\/L016494\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/S019901\/1"],"award-info":[{"award-number":["EP\/S019901\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012530","name":"Gebze Teknik \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Arastirma Kurumu","doi-asserted-by":"publisher","award":["1059B192400100"],"award-info":[{"award-number":["1059B192400100"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM136614"],"award-info":[{"award-number":["T32GM136614"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cys2-His2 (C2H2) zinc finger (ZF)-containing proteins are the largest family of human DNA-binding transcription factors (TFs), a class of proteins that has long been considered undruggable. Significant progress has recently been made in the development of immunomodulatory imide drugs (IMiDs) that induce the degradation of proteins that possess the G-loop CXXCG degron, including these transcription factors. Despite these advances, the identification of IMiD-based molecular glues that selectively induce the degradation of a single protein, and the rational design of such compounds, remains challenging. Here we report the serendipitous discovery that 5-tBu-thalidomide (tBu-Thal, 5) potently and selectively induces proteasomal degradation of a single C2H2 ZF-containing TF, FLT3 interacting zinc finger 1 (FIZ1), in six cell lines. While FIZ1 contains 11 C2H2 ZFs, six of which contain the G-loop CXXCG degron necessary for IMiD-induced degradation, we demonstrate that this degradation is mediated exclusively by ZF8. Computational modeling of the CRL4CRBN-IMiD-FIZ1 complex enabled rationalization of why tBu-Thal (5) selectively engages with ZF8, and hints at a strategy for more rational design of selective IMiD-based degraders. tBu-Thal (5) was employed in ChIP-seq studies to identify a motif matching the CRX binding site, consistent with prior reports. We also identified enriched motifs resembling binding sites of the transcription factors ZBTB32 and ARID3a, which have not previously been associated with FIZ1. IP-MS studies indicated that FIZ1 associates with C1QBP and YBX1. C1QBP is involved in DNA damage repair, suggesting a role for FIZ1 in this process. These data show that tBu-Thal (5) is a powerful molecular tool to selectively dissect the role of FIZ1 in complex biological settings.<\/jats:p>","DOI":"10.1021\/jacs.6c14185","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:26:32Z","timestamp":1788452792000},"page":"39285-39298","source":"Crossref","is-referenced-by-count":0,"title":["5-\n                    <i>t<\/i>\n                    Bu-Thalidomide\nIs a Selective Molecular Glue Degrader of the Transcription Factor\nFLT3 Interacting Zinc Finger 1 (FIZ1)"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8737-9370","authenticated-orcid":true,"given":"Patrick J.","family":"Brennan","sequence":"first","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"University of Oxford , , ,","place":["Oxford, U.K., OX1 3TA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , , , ,","place":["New York, New York, United States, 10065"]},{"name":"Memorial Sloan Kettering Cancer Center , , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-8520","authenticated-orcid":true,"given":"Alban","family":"Ordureau","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6615-8906","authenticated-orcid":true,"given":"Sarah E.","family":"Singleton","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Li","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Albayrak","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"Gebze Technical University , , ,","place":["Kocaeli, Tu\u0308rkiye, 41400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor H.","family":"Chang","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0608-6518","authenticated-orcid":true,"given":"Lorena","family":"Yu Liao","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-2252","authenticated-orcid":true,"given":"Charlotte M.","family":"Deane","sequence":"additional","affiliation":[{"name":"University of Oxford , , ,","place":["Oxford, U.K., OX1 3LB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-5261","authenticated-orcid":true,"given":"Kendall N.","family":"Houk","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-9505","authenticated-orcid":true,"given":"Michael M.","family":"Hann","sequence":"additional","affiliation":[{"name":"GSK, Medicines Research Centre , ,","place":["Stevenage, U.K., SG1 2NY"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis L.","family":"Brayshaw","sequence":"additional","affiliation":[{"name":"GSK, Medicines Research Centre , ,","place":["Stevenage, U.K., SG1 2NY"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-4077","authenticated-orcid":true,"given":"Heeseon","family":"An","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , , , ,","place":["New York, New York, United States, 10065"]},{"name":"Memorial Sloan Kettering Cancer Center , , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-117X","authenticated-orcid":true,"given":"Stuart J.","family":"Conway","sequence":"additional","affiliation":[{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"University of Oxford , , ,","place":["Oxford, U.K., OX1 3TA"]},{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]},{"name":"University of California Los Angeles , , , ,","place":["Los Angeles, California, United States, 90095"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"4","key":"2026091609123943600_cit1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human Transcription Factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"issue":"10","key":"2026091609123943600_cit2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nrc906","article-title":"Transcription\nFactors as Targets for Cancer Therapy","volume":"2","author":"Darnell","year":"2002","journal-title":"Nat.\nRev. Cancer"},{"issue":"9","key":"2026091609123943600_cit3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41573-021-00199-0","article-title":"Advances in Targeting \u2018Undruggable\u2019 Transcription\nFactors with Small Molecules","volume":"20","author":"Henley","year":"2021","journal-title":"Nat. Rev. Drug\nDiscovery"},{"key":"2026091609123943600_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2024.102836","article-title":"Updated Understanding\nof the Protein\u2013DNA\nRecognition Code Used by C2H2 Zinc Finger Proteins","volume":"87","author":"Zhang","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"5971","key":"2026091609123943600_cit5","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1126\/science.1177319","article-title":"Identification of a\nPrimary Target of Thalidomide Teratogenicity","volume":"327","author":"Ito","year":"2010","journal-title":"Science"},{"issue":"6168","key":"2026091609123943600_cit6","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1126\/science.1244851","article-title":"Lenalidomide Causes\nSelective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells","volume":"343","author":"Kro\u0308nke","year":"2014","journal-title":"Science"},{"issue":"6168","key":"2026091609123943600_cit7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1126\/science.1244917","article-title":"Jr., W. G. K. The\nMyeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction\nof Ikaros Proteins","volume":"343","author":"Lu","year":"2014","journal-title":"Science"},{"issue":"10","key":"2026091609123943600_cit8","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/s41589-018-0129-x","article-title":"SALL4Mediates Teratogenicity as a\nThalidomide-Dependent Cereblon Substrate","volume":"14","author":"Matyskiela","year":"2018","journal-title":"Nat.\nChem. Biol."},{"key":"2026091609123943600_cit9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38430","article-title":"Thalidomide\nPromotes Degradation\nof SALL4, a Transcription Factor Implicated in Duane Radial Ray Syndrome","volume":"7","author":"Donovan","year":"2018","journal-title":"eLife"},{"issue":"13","key":"2026091609123943600_cit10","doi-asserted-by":"publisher","first-page":"6648","DOI":"10.1021\/acs.jmedchem.9b01928","article-title":"Discovery of CRBN E3 Ligase Modulator\nCC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma","volume":"63","author":"Hansen","year":"2020","journal-title":"J. Med. Chem."},{"issue":"6","key":"2026091609123943600_cit11","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/s41589-021-00802-w","article-title":"Acute Pharmacological\nDegradation of Helios Destabilizes Regulatory T Cells","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"3","key":"2026091609123943600_cit12","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.chembiol.2023.02.005","article-title":"Discovery and Characterization\nof a Selective IKZF2 Glue Degrader for Cancer Immunotherapy","volume":"30","author":"Bonazzi","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"46","key":"2026091609123943600_cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c06127","article-title":"Discovery\nof CRBN-Dependent WEE1Molecular\nGlue Degraders from a Multicomponent Combinatorial Library","volume":"146","author":"Razumkov","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"6704","key":"2026091609123943600_cit14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.adk6129","article-title":"A Molecular Glue\nDegrader of the WIZ Transcription Factor for Fetal Hemoglobin Induction","volume":"385","author":"Ting","year":"2024","journal-title":"Science"},{"issue":"22","key":"2026091609123943600_cit15","doi-asserted-by":"publisher","first-page":"20682","DOI":"10.1021\/acs.jmedchem.4c02251","article-title":"Discovery and Optimization\nof First-in-Class Molecular Glue Degraders of the WIZ Transcription\nFactor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease","volume":"67","author":"Kerrigan","year":"2024","journal-title":"J. Med. Chem."},{"key":"2026091609123943600_cit16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41589-025-01978-1","article-title":"ZBTB11 Depletion\nTargets Metabolic Vulnerabilities\nin KRAS Inhibitor-Resistant PDAC","author":"Tran","year":"2025","journal-title":"Nat. Chem.\nBiol."},{"issue":"12","key":"2026091609123943600_cit17","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1021\/acschembio.0c00674","article-title":"Cereblon Modulators\nTarget ZBTB16 and Its Oncogenic Fusion Partners for Degradation via\nDistinct Structural Degrons","volume":"15","author":"Matyskiela","year":"2020","journal-title":"ACS Chem. Biol."},{"issue":"6755","key":"2026091609123943600_cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.adt6736","article-title":"Mining the CRBN\nTarget Space Redefines Rules for Molecular Glue\u2013Induced Neosubstrate\nRecognition","volume":"389","author":"Petzold","year":"2025","journal-title":"Science"},{"issue":"16","key":"2026091609123943600_cit19","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1016\/j.molcel.2025.07.019","article-title":"Expanding the Druggable Zinc-Finger\nProteome Defines Properties of Drug-Induced Degradation","volume":"85","author":"S\u0142abicki","year":"2025","journal-title":"Mol. Cell"},{"issue":"1","key":"2026091609123943600_cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62829-0","article-title":"Unbiased Mapping of Cereblon Neosubstrate Landscape\nby High-Throughput Proteomics","volume":"16","author":"Steger","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"2026091609123943600_cit21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1158\/2643-3230.bcd-20-0105","article-title":"Avadomide Induces Degradation of\nZMYM2 Fusion Oncoproteins in Hematologic Malignancies","volume":"2","author":"Renneville","year":"2021","journal-title":"Blood Cancer Discovery"},{"issue":"3","key":"2026091609123943600_cit22","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1021\/acs.jmedchem.4c02415","article-title":"Development of Potent and Selective\nCK1\u03b1 Molecular\nGlue Degraders","volume":"68","author":"Geng","year":"2025","journal-title":"J. Med. Chem."},{"issue":"10","key":"2026091609123943600_cit23","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1021\/acschembio.0c00520","article-title":"Selective Degradation of GSPT1 by Cereblon Modulators\nIdentified via a Focused Combinatorial Library","volume":"15","author":"Powell","year":"2020","journal-title":"ACS Chem. Biol."},{"issue":"5","key":"2026091609123943600_cit24","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1182\/blood.2020008676","article-title":"CC-90009,\na Novel Cereblon E3 Ligase Modulator, Targets Acute Myeloid Leukemia\nBlasts and Leukemia Stem Cells","volume":"137","author":"Surka","year":"2021","journal-title":"Blood"},{"issue":"7","key":"2026091609123943600_cit25","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.chembiol.2025.06.005","article-title":"A Cereblon-Based Glue Degrader of\nNEK7 Regulates NLRP3 Inflammasome in a Context-Dependent Manner","volume":"32","author":"Sylvain","year":"2025","journal-title":"Cell Chem. Biol."},{"issue":"6414","key":"2026091609123943600_cit26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0572","article-title":"Defining\nthe Human C2H2 Zinc Finger Degrome Targeted by Thalidomide Analogs\nthrough CRBN","volume":"362","author":"Sievers","year":"2018","journal-title":"Science"},{"issue":"2","key":"2026091609123943600_cit27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.exer.2006.10.009","article-title":"FIZ1 Is Expressed\nduring Photoreceptor\nMaturation, and Synergizes with NRL and CRX at Rod-Specific Promoters\nin Vitro","volume":"84","author":"Mali","year":"2007","journal-title":"Exp. Eye Res."},{"issue":"13","key":"2026091609123943600_cit28","article-title":"Spatial and Temporal\nExpression Patterns of Fiz1, Implicating Its Role in the Control of\nPhotoreceptor Gene Expression in Vivo","volume":"47","author":"Mitton","year":"2006","journal-title":"Invest.\nOphthalmol. Visual Sci."},{"issue":"13","key":"2026091609123943600_cit29","first-page":"3961","article-title":"Fiz1, a Protein That\nAttenuates Transactivation of the Rhodopsin Promoter, Is Expressed\nDuring Maturation of Photoreceptors in Developing Neural Retina","volume":"46","author":"Mitton","year":"2005","journal-title":"Invest. Opthalmol. Visual Sci."},{"issue":"13","key":"2026091609123943600_cit30","first-page":"714","article-title":"Fiz1: A Novel Zinc\u2013Finger\nProtein Binds the NRL Transcription Factor Using Internal Domains\nDifferent from Its RTK\u2013Binding Domains","volume":"45","author":"Mitton","year":"2004","journal-title":"Invest. Opthalmol. Visual Sci."},{"issue":"30","key":"2026091609123943600_cit31","doi-asserted-by":"publisher","first-page":"21478","DOI":"10.1074\/jbc.274.30.21478","article-title":"Fiz1, a Novel Zinc Finger Protein Interacting with\nthe Receptor Tyrosine Kinase Flt3","volume":"274","author":"Wolf","year":"1999","journal-title":"J. Biol.\nChem."},{"issue":"1","key":"2026091609123943600_cit32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1189\/jlb.1109748","article-title":"Dual Retrovirus Integration\nTagging: Identification of New Signaling Molecules Fiz1 and Hipk2\nThat Are Involved in the IL-7 Signaling Pathway in B Lymphoblastic\nLymphomas","volume":"88","author":"Tsuruyama","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"2026091609123943600_cit33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-9-87","article-title":"FIZ1 Is Part of\nthe Regulatory Protein Complex on Active\nPhotoreceptor-Specific Gene Promoters in Vivo","volume":"9","author":"Mali","year":"2008","journal-title":"BMC Mol. Biol."},{"issue":"4","key":"2026091609123943600_cit34","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/hmg\/ddg035","article-title":"Interaction of Retinal bZIP Transcription Factor NRL\nwith Flt3-Interacting Zinc-Finger Protein Fiz1: Possible Role of Fiz1\nas a Transcriptional Repressor","volume":"12","author":"Mitton","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"2026091609123943600_cit35","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1021\/pr500392m","article-title":"Dissection of a Novel Autocrine Signaling\nPathway via Quantitative Secretome and Interactome Mapping","volume":"13","author":"Larivie\u0300re","year":"2014","journal-title":"J. Proteome Res."},{"issue":"11","key":"2026091609123943600_cit36","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1021\/acschembio.5c00751","article-title":"Orthogonal\nIMiD-Degron Pairs Induce Selective Protein Degradation in Cells","volume":"20","author":"Brennan","year":"2025","journal-title":"ACS Chem. Biol."},{"issue":"10","key":"2026091609123943600_cit37","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.chembiol.2018.07.001","article-title":"The Bump-and-Hole\nTactic: Expanding the Scope of Chemical Genetics","volume":"25","author":"Islam","year":"2018","journal-title":"Cell Chem. Biol."},{"issue":"15","key":"2026091609123943600_cit38","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/cmdc.201800271","article-title":"Efficient\nSynthesis of Immunomodulatory\nDrug Analogues Enables Exploration of Structure\u2013Degradation\nRelationships","volume":"13","author":"Burslem","year":"2018","journal-title":"ChemMedChem"},{"issue":"4","key":"2026091609123943600_cit39","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0960-894X(98)00029-8","article-title":"Potent and Selective\nInhibitors of\nthe Proteasome: Dipeptidyl Boronic Acids","volume":"8","author":"Adams","year":"1998","journal-title":"Bioorg.\nMed. Chem. Lett."},{"issue":"7239","key":"2026091609123943600_cit40","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nature07884","article-title":"An Inhibitor\nof NEDD8-Activating Enzyme as a New Approach to Treat Cancer","volume":"458","author":"Soucy","year":"2009","journal-title":"Nature"},{"issue":"26","key":"2026091609123943600_cit41","doi-asserted-by":"publisher","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin\nA1, a Specific Inhibitor of Vacuolar-Type H(+)-ATPase, Inhibits Acidification\nand Protein Degradation in Lysosomes of Cultured Cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"3","key":"2026091609123943600_cit42","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bbrc.2016.06.091","article-title":"Nuclear Cereblon\nModulates Transcriptional\nActivity of Ikaros and Regulates Its Downstream Target, Enkephalin,\nin Human Neuroblastoma Cells","volume":"477","author":"Wada","year":"2016","journal-title":"Biochem. Biophys.\nRes. Commun."},{"issue":"11","key":"2026091609123943600_cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080732","article-title":"Constitutive Function\nof the Ikaros Transcription Factor in Primary Leukemia Cells from\nPediatric Newly Diagnosed High-Risk and Relapsed B-Precursor ALL Patients","volume":"8","author":"Uckun","year":"2013","journal-title":"PLoS One"},{"key":"2026091609123943600_cit44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.coi.2017.11.005","article-title":"The Ikaros Family in\nLymphocyte Development","volume":"51","author":"Heizmann","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"10","key":"2026091609123943600_cit45","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0898-6568(98)00042-4","article-title":"Casein Kinase I\nSpatial Organization and Positioning\nof a Multifunctional Protein Kinase Family","volume":"10","author":"Gross","year":"1998","journal-title":"Cell. Signaling"},{"key":"2026091609123943600_cit46","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly Accurate Protein\nStructure Prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"13","key":"2026091609123943600_cit47","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1158\/0008-5472.CAN-06-4086","article-title":"Antitumor Activity of PR-171, a Novel\nIrreversible\nInhibitor of the Proteasome","volume":"67","author":"Demo","year":"2007","journal-title":"Cancer Res."},{"issue":"6","key":"2026091609123943600_cit48","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.chembiol.2015.05.009","article-title":"Hijacking the E3 Ubiquitin Ligase\nCereblon to Efficiently Target BRD4","volume":"22","author":"Lu","year":"2015","journal-title":"Chem. Biol."},{"issue":"5","key":"2026091609123943600_cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2024.101960","article-title":"Thalidomide Derivatives Degrade BCL-2\nby Reprogramming the Binding Surface of CRBN","volume":"5","author":"Wang","year":"2024","journal-title":"Cell Rep. Phys. Sci."},{"issue":"16","key":"2026091609123943600_cit50","doi-asserted-by":"publisher","first-page":"6187","DOI":"10.1074\/jbc.M117.816868","article-title":"Ligand-Mediated\nProtein Degradation Reveals Functional\nConservation among Sequence Variants of the CUL4-Type E3 Ligase Substrate\nReceptor Cereblon","volume":"293","author":"Akuffo","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"40","key":"2026091609123943600_cit51","doi-asserted-by":"publisher","first-page":"36352","DOI":"10.1021\/jacs.5c10240","article-title":"Indolequinone-Based\nHypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade\nBRD4 in Hypoxic Cancer Cells","volume":"147","author":"Serafini","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"2026091609123943600_cit52","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41594-020-0405-9","article-title":"Crystal\nStructure of the SALL4\u2013Pomalidomide\u2013Cereblon\u2013DDB1\nComplex","volume":"27","author":"Matyskiela","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2026091609123943600_cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2019.100187","article-title":"Mutations\nof FLT3 Receptor Affect Its Surface Glycosylation, Intracellular Localization,\nand Downstream Signaling","volume":"13","author":"Takahashi","year":"2020","journal-title":"Leuk. Res. Rep."},{"issue":"1","key":"2026091609123943600_cit54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/sj.neo.7900197","article-title":"Stable Karyotypes in Epithelial Cancer\nCell Lines Despite\nHigh Rates of Ongoing Structural and Numerical Chromosomal Instability","volume":"4","author":"Roschke","year":"2002","journal-title":"Neoplasia"},{"issue":"6","key":"2026091609123943600_cit55","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.molcel.2019.06.023","article-title":"C1QBP Promotes\nHomologous Recombination by Stabilizing MRE11 and Controlling the\nAssembly and Activation of MRE11\/RAD50\/NBS1 Complex","volume":"75","author":"Bai","year":"2019","journal-title":"Mol. Cell"},{"issue":"1","key":"2026091609123943600_cit56","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.chembiol.2024.10.007","article-title":"Degradome\nAnalysis to Identify Direct\nProtein Substrates of Small-Molecule Degraders","volume":"32","author":"Jochem","year":"2025","journal-title":"Cell Chem. Biol."},{"issue":"22","key":"2026091609123943600_cit57","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505053","article-title":"Cross-Linking Profiling of Molecular\nGlue Degrader-Induced E3 Ligase Interactome to Expand Target Space","volume":"64","author":"Xu","year":"2025","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c14185","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/36\/39285\/68199530\/jacs.6c14185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/36\/39285\/68199530\/jacs.6c14185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:29:56Z","timestamp":1789565396000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/36\/39285\/5405254\/5-tBu-Thalidomide-Is-a-Selective-Molecular-Glue"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":57,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2026,9,2]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c14185","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}