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Herein, we report a general and versatile copper-catalyzed platform for chemo- and enantioselective radical 1,2-carbosulfenylation of a diverse range of alkenes. Central to this strategy is the development of a tunable and readily accessible library of multidentate anionic N,N,N(P)-ligands, which promote the desired transformation while suppressing competing radical pathways, thereby enabling broad compatibility with various alkyl radical precursors and transformable sulfur nucleophiles. The protocol exhibits a broad substrate scope, accommodating electronically diverse alkenes, including monosubstituted and 1,1-disubstituted acrylamides, as well as aryl- or heteroaryl-substituted alkenes, along with alkyl bromides and chlorides as radical precursors. The resulting products can be readily converted into a range of enantioenriched alkyl sulfur-containing building blocks of value in organic synthesis and related fields.<\/jats:p>","DOI":"10.1021\/jacs.6c14452","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:02:07Z","timestamp":1791540127000},"page":"44811-44821","source":"Crossref","is-referenced-by-count":0,"title":["Copper-Catalyzed Chemo-\nand Enantioselective Radical\n1,2-Carbosulfenylation of Diverse Alkenes with Broad Radical and Sulfur\nCompatibility"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7351-8596","authenticated-orcid":true,"given":"Fu","family":"Liu","sequence":"first","affiliation":[{"name":"South China University of Technology , , ,","place":["Guangzhou, China, 510641"]},{"name":"Southern University of Science and Technology , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Great Bay University , , ,","place":["Dongguan, China, 523000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-1145","authenticated-orcid":true,"given":"Derong","family":"Cao","sequence":"additional","affiliation":[{"name":"South China University of Technology , , ,","place":["Guangzhou, China, 510641"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-6465","authenticated-orcid":true,"given":"Xin-Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2026102111075235500_cit1","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1021\/cr100371y","article-title":"Palladium(II)-Catalyzed Alkene Functionalization via\nNucleopalladation: Stereochemical Pathways and Enantioselective Catalytic\nApplications","volume":"111","author":"McDonald","year":"2011","journal-title":"Chem. 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Lett."},{"key":"2026102111075235500_cit27","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1021\/acs.orglett.5b02423","article-title":"Asymmetric\nMulticomponent Sulfa-Michael\/Mannich Cascade Reaction: Synthetic Access\nto 1,2-Diamino-3-Organosulfur Compounds and 2-Nitro Allylic Amines","volume":"17","author":"Hou","year":"2015","journal-title":"Org. Lett."},{"key":"2026102111075235500_cit28","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/adsc.201600026","article-title":"An Enantioselective Three-Component\nSulfa-Michael\/Aldol\nCascade Reaction and its Application to the Synthesis of Thioaryl\nSubstituted (\u2212)-Bestatin Derivatives","volume":"358","author":"Hou","year":"2016","journal-title":"Adv. Synth. 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