{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:11Z","timestamp":1792784771832,"version":"4.5.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BX20240195"],"award-info":[{"award-number":["BX20240195"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["SRICSPYF-ZY2025039"],"award-info":[{"award-number":["SRICSPYF-ZY2025039"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015397","name":"Department of Science and Technology of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032887","name":"Ordos Laboratory","doi-asserted-by":"publisher","award":["Ordoslab-kjzc-202506"],"award-info":[{"award-number":["Ordoslab-kjzc-202506"]}],"id":[{"id":"10.13039\/100032887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032887","name":"Ordos Laboratory","doi-asserted-by":"publisher","award":["Ordoslab-sysjc-202502"],"award-info":[{"award-number":["Ordoslab-sysjc-202502"]}],"id":[{"id":"10.13039\/100032887","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HE Science Foundation"},{"name":"Natural Science Foundation of Inner Mongolia","award":["2025QN02065"],"award-info":[{"award-number":["2025QN02065"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22238004"],"award-info":[{"award-number":["22238004"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22275110"],"award-info":[{"award-number":["22275110"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22322203"],"award-info":[{"award-number":["22322203"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["223B2205"],"award-info":[{"award-number":["223B2205"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22602003"],"award-info":[{"award-number":["22602003"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extra-large-pore zeolites extend molecular shape selectivity toward bulky substrates, yet crystallographic pore size alone may not determine molecular accessibility in a real crystal. Here, we use low-dose iDPC-STEM and electron ptychography to establish the effective pore architecture of ZEO-1, a fully connected aluminosilicate containing intersecting 16- and 12-membered-ring channels. While the bulk framework retains its ideal topology, imaging reveals distinct termination motifs at the crystal surfaces and defect-containing intergrowths at the crystal edges. The dominant {020} facets expose both channel systems with truncated 12-membered-ring motifs resolved at their projected boundaries. At crystal edges, ZEO-1 joins zeolite Beta through a cross-ring-size intergrowth that connects frameworks with different apertures. Direct imaging of the organic structure-directing agent and aromatic guests of increasing size further reveals a transition from occupation of both channel systems to confinement within the 16-membered-ring channels alone. Thus, the chemically accessible pore space of an extra-large-pore zeolite is defined collectively by bulk topology, surface termination, local interfaces, and molecular size. These findings shift extra-large-pore design from maximizing ring size toward engineering whole-crystal accessibility.<\/jats:p>","DOI":"10.1021\/jacs.6c15533","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:01:23Z","timestamp":1791273683000},"page":"44984-44990","source":"Crossref","is-referenced-by-count":0,"title":["Local\nStructures Associated with Molecular Access\nin an Extra-Large-Pore Zeolite"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-7754","authenticated-orcid":true,"given":"Hao","family":"Xiong","sequence":"first","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]},{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siru","family":"Liu","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefang","family":"Niu","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Ma","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"He","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-6146","authenticated-orcid":true,"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]},{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8675-7973","authenticated-orcid":true,"given":"Fei","family":"Wei","sequence":"additional","affiliation":[{"name":"Ordos Laboratory , , ,","place":["Ordos, Inner Mongolia, China, 017000"]},{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026102111101133300_cit1","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1021\/cr960406n","article-title":"From Microporous\nto Mesoporous Molecular Sieve Materials and Their Use in Catalysis","volume":"97","author":"Corma","year":"1997","journal-title":"Chem. Rev."},{"key":"2026102111101133300_cit2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nature00785","article-title":"Ordered\nporous materials for emerging applications","volume":"417","author":"Davis","year":"2002","journal-title":"Nature"},{"key":"2026102111101133300_cit3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0021-9517(02)00132-X","article-title":"State of the\nart and future challenges of zeolites as catalysts","volume":"216","author":"Corma","year":"2003","journal-title":"J. Catal."},{"key":"2026102111101133300_cit4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/381295a0","article-title":"A high-silica zeolite with a 14-tetrahedral-atom\npore\nopening","volume":"381","author":"Freyhardt","year":"1996","journal-title":"Nature"},{"key":"2026102111101133300_cit5","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1126\/science.1098242","article-title":"Extra-Large-Pore Zeolites\nwith Two-Dimensional Channels Formed by 14 and 12 Rings","volume":"304","author":"Paillaud","year":"2004","journal-title":"Science"},{"key":"2026102111101133300_cit6","doi-asserted-by":"publisher","first-page":"13570","DOI":"10.1021\/ja507615b","article-title":"EMM-23: A Stable High-Silica Multidimensional Zeolite with Extra-Large\nTrilobe-Shaped Channels","volume":"136","author":"Willhammar","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"2026102111101133300_cit7","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1126\/science.abk3258","article-title":"A stable aluminosilicate\nzeolite with intersecting three-dimensional\nextra-large pores","volume":"374","author":"Lin","year":"2021","journal-title":"Science"},{"key":"2026102111101133300_cit8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1126\/science.ade1771","article-title":"A 3D extra-large-pore\nzeolite enabled by 1D-to-3D topotactic condensation\nof a chain silicate","volume":"379","author":"Li","year":"2023","journal-title":"Science"},{"key":"2026102111101133300_cit9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41586-024-07194-6","article-title":"Interchain-expanded\nextra-large-pore zeolites","volume":"628","author":"Gao","year":"2024","journal-title":"Nature"},{"key":"2026102111101133300_cit10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41586-024-08206-1","article-title":"A stable zeolite with\natomically ordered and interconnected mesopore\nchannel","volume":"636","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"2026102111101133300_cit11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.aec4882","article-title":"A 36-ring zeolite with\nintrinsic cylindrical mesopores","volume":"392","author":"Sun","year":"2026","journal-title":"Science"},{"key":"2026102111101133300_cit12","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1201\/97802039111","volume-title":"Handbook of zeolite\nscience and technology","author":"Auerbach","year":"2003","edition":"1st"},{"key":"2026102111101133300_cit13","doi-asserted-by":"publisher","first-page":"5226","DOI":"10.1021\/cm0488534","article-title":"Surface structure\nof zeolite (MFI) crystals","volume":"16","author":"Di\u0301az","year":"2004","journal-title":"Chem. Mater."},{"key":"2026102111101133300_cit14","doi-asserted-by":"publisher","first-page":"11598","DOI":"10.1021\/acscatal.3c01932","article-title":"Surface diffusion barriers\nand catalytic activity driven by terminal\ngroups at zeolite catalysts","volume":"13","author":"Gao","year":"2023","journal-title":"ACS Catal."},{"key":"2026102111101133300_cit15","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1038\/s41563-019-0486-1","article-title":"Graph similarity\ndrives zeolite diffusionless transformations and intergrowth","volume":"18","author":"Schwalbe-Koda","year":"2019","journal-title":"Nat. Mater."},{"issue":"12","key":"2026102111101133300_cit16","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1038\/s41563-025-02377-6","article-title":"Drawing boundaries between feasible\nand unfeasible\nzeolite intergrowths using high-throughput computational screening\nwith synthesis validation","volume":"24","author":"Oishi","year":"2025","journal-title":"Nat. Mater."},{"key":"2026102111101133300_cit17","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/nmat2530","article-title":"Morphology-dependent\nzeolite intergrowth structures leading to distinct\ninternal and outer-surface molecular diffusion barriers","volume":"8","author":"Karwacki","year":"2009","journal-title":"Nat. Mater."},{"key":"2026102111101133300_cit18","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.1021\/jacs.9b13817","article-title":"Cooperative and competitive occlusion of organic and\ninorganic structure-directing agents within chabazite zeolites influences\ntheir aluminum arrangement","volume":"142","author":"Di Iorio","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026102111101133300_cit19","doi-asserted-by":"publisher","first-page":"28965","DOI":"10.1021\/jacs.5c07054","article-title":"In Situ Quantitative\nImaging of Nonuniformly Distributed Molecules\nin Zeolites","volume":"147","author":"Xiong","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026102111101133300_cit20","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1038\/s41467-021-22438-z","article-title":"Resolving atomic SAPO-34\/18\nintergrowth architectures for methanol\nconversion by identifying light atoms and bonds","volume":"12","author":"Shen","year":"2021","journal-title":"Nat. Commun."},{"key":"2026102111101133300_cit21","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201837","article-title":"Tunable CHA\/AEI Zeolite\nIntergrowths with A Priori Biselective Organic\nStructure-Directing Agents: Controlling Enrichment and Implications\nfor Selective Catalytic Reduction of NOx","volume":"61","author":"Bello-Jurado","year":"2022","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026102111101133300_cit22","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1038\/ncomms5262","article-title":"\u03c0\u2013\u03c0 interaction of aromatic groups in amphiphilic\nmolecules directing for single-crystalline mesostructured zeolite\nnanosheets","volume":"5","author":"Xu","year":"2014","journal-title":"Nat. Commun."},{"key":"2026102111101133300_cit23","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1038\/s41467-022-30538-7","article-title":"Modulating inherent lewis acidity at the intergrowth interface of\nmortise-tenon zeolite catalyst","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"2026102111101133300_cit24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf6865","article-title":"Direct imaging of local\natomic structures in zeolite using optimum\nbright-field scanning transmission electron microscopy","volume":"9","author":"Ooe","year":"2023","journal-title":"Sci. Adv."},{"key":"2026102111101133300_cit25","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1126\/science.adg3183","article-title":"Three-dimensional inhomogeneity of zeolite structure and composition\nrevealed by electron ptychography","volume":"380","author":"Zhang","year":"2023","journal-title":"Science"},{"key":"2026102111101133300_cit26","doi-asserted-by":"publisher","first-page":"8713","DOI":"10.1021\/jacs.1c02654","article-title":"Synthesis and Structure\nof a 22 \u00d7 12 \u00d7 12 Extra-Large Pore\nZeolite ITQ-56 Determined by 3D Electron Diffraction","volume":"143","author":"Kapaca","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026102111101133300_cit27","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/s41557-019-0257-2","article-title":"Isotherms of individual pores by gas adsorption crystallography","volume":"11","author":"Cho","year":"2019","journal-title":"Nat. Chem."},{"key":"2026102111101133300_cit28","doi-asserted-by":"publisher","first-page":"13632","DOI":"10.1021\/jacs.7b07139","article-title":"Single-Molecule Fluorescence Microscopy Reveals\nLocal Diffusion Coefficients\nin the Pore Network of an Individual Catalyst Particle","volume":"139","author":"Hendriks","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026102111101133300_cit29","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1038\/s41467-020-17355-6","article-title":"Imaging spatiotemporal evolution of molecules and active sites in\nzeolite catalyst during methanol-to-olefins reaction","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"key":"2026102111101133300_cit30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41586-021-03429-y","article-title":"A single-molecule van\nder Waals compass","volume":"592","author":"Shen","year":"2021","journal-title":"Nature"},{"key":"2026102111101133300_cit31","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41586-022-04876-x","article-title":"Atomic imaging of zeolite-confined\nsingle molecules by electron microscopy","volume":"607","author":"Shen","year":"2022","journal-title":"Nature"},{"key":"2026102111101133300_cit32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1126\/science.abn7667","article-title":"In situ imaging of the\nsorption-induced subcell topological flexibility\nof a rigid zeolite framework","volume":"376","author":"Xiong","year":"2022","journal-title":"Science"},{"key":"2026102111101133300_cit33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1021\/acscentsci.7b00555","article-title":"Cutting Materials in\nHalf: A Graph Theory Approach for Generating\nCrystal Surfaces and Its Prediction of 2D Zeolites","volume":"4","author":"Witman","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"2026102111101133300_cit34","doi-asserted-by":"publisher","first-page":"14927","DOI":"10.1021\/acs.jpcc.4c03138","article-title":"Unveiling the Structure\u2013Surface Energy Relationship\nof Zeolites\nthrough Machine Learning","volume":"128","author":"Ma","year":"2024","journal-title":"J. Phys. Chem. C"},{"key":"2026102111101133300_cit35","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1021\/jacs.6b02953","article-title":"Locating Organic Guests\nin Inorganic Host Materials from X-ray Powder\nDiffraction Data","volume":"138","author":"Smeets","year":"2016","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c15533","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/41\/44984\/68752520\/jacs.6c15533.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/41\/44984\/68752520\/jacs.6c15533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:31:29Z","timestamp":1792596689000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/41\/44984\/5444960\/Local-Structures-Associated-with-Molecular-Access"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":35,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2026,10,6]]},"published-print":{"date-parts":[[2026,10,21]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c15533","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]}}}