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The selective activation and functionalization of C(sp3)\u2013C(sp3) bonds, however, remains a formidable challenge for generalizing these methods to saturated rings. We report an operationally straightforward, one-step method for the formal insertion of nitrogen atoms into the skeletal cores of saturated carbocycles. This method leverages the underexplored ability of nitrogen-centered radical intermediates to trigger deconstructive \u03b2-scission events, and we have discovered a Cu(II) system that both generates nitrogen-centered radicals directly from sulfonamides and mediates the oxidative cyclization of the ring-opened organoradical intermediates. Given its broad functional group tolerance, scalability, and capacity for late-stage scaffold-hopping, this strategy establishes nitrogen-centered radical-mediated \u03b2-scission as a viable, general tool for the synthesis of nitrogen heterocycles by skeletal editing.<\/jats:p>","DOI":"10.1021\/jacs.6c15884","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:01:58Z","timestamp":1791428518000},"page":"44005-44011","source":"Crossref","is-referenced-by-count":0,"title":["Copper-Mediated\nNitrogen-Atom Migration into Saturated\nCarbocycles"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0454-342X","authenticated-orcid":true,"given":"Michael J.","family":"Zeiler","sequence":"first","affiliation":[{"name":"University of Wisconsin\u2212Madison , , 1101 University Avenue , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3134-9163","authenticated-orcid":true,"given":"Matthieu F.","family":"Maciejewski","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2212Madison , , 1101 University Avenue , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-6486","authenticated-orcid":true,"given":"Cade A.","family":"MacAllister","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2212Madison , , 1101 University Avenue , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3934-4973","authenticated-orcid":true,"given":"Tehshik P.","family":"Yoon","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2212Madison , , 1101 University Avenue , , ,","place":["Madison, Wisconsin, United States, 53706"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026102111073166000_cit1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s44160-022-00052-1","article-title":"Single-Atom\nLogic for Heterocycle Editing","volume":"1","author":"Jurczyk","year":"2022","journal-title":"Nat. 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