{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:22:01Z","timestamp":1791778921606,"version":"4.3.4"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS139872"],"award-info":[{"award-number":["R01NS139872"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1NS126073"],"award-info":[{"award-number":["RF1NS126073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Here we report blue light-driven in vivo photoactivation of TCA-DCCM-DAMGO, a caged derivative of the \u03bc-opioid receptor (MOR) agonist DAMGO. TCA-DCCM-DAMGO is chemically stable in the dark, is inactive prior to illumination, and cleanly liberates DAMGO upon irradiation with blue light. Brain slice electrophysiology demonstrates rapid, light-triggered MOR activation. Following intracerebroventricular infusion of TCA-DCCM-DAMGO in the mouse brain, photoactivation in the ventral tegmental area with blue light elicited a rapid, opioid-dependent increase in locomotion. These results demonstrate the feasibility of in vivo photouncaging using blue light deep in the mouse brain and establish TCA-DCCM-DAMGO as a probe for manipulating endogenous opioid receptors in behaving animals.<\/jats:p>","DOI":"10.1021\/jacs.6c15989","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:01:47Z","timestamp":1787248907000},"page":"36359-36364","source":"Crossref","is-referenced-by-count":1,"title":["Photouncaging\nof an Opioid Peptide in Vivo Using Blue\nLight"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9903-1407","authenticated-orcid":true,"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Seok","family":"Song","sequence":"additional","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Li","sequence":"additional","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayra","family":"Nawsheen","sequence":"additional","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhu","family":"Liao","sequence":"additional","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Martin","sequence":"additional","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-2932","authenticated-orcid":true,"given":"Matthew R.","family":"Banghart","sequence":"additional","affiliation":[{"name":"University of California San Diego , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"8","key":"2026090312094782200_cit1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nmeth1072","article-title":"Caged\nCompounds: Photorelease Technology for Control of Cellular Chemistry\nand Physiology","volume":"4","author":"Ellis-Davies","year":"2007","journal-title":"Nat. Methods"},{"issue":"1","key":"2026090312094782200_cit2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1021\/cr300177k","article-title":"Photoremovable\nProtecting Groups in Chemistry and Biology: Reaction Mechanisms and\nEfficacy","volume":"113","author":"Kla\u0301n","year":"2013","journal-title":"Chem. Rev."},{"issue":"21","key":"2026090312094782200_cit3","doi-asserted-by":"publisher","first-page":"10748","DOI":"10.1021\/acs.chemrev.7b00723","article-title":"Restoring Vision\nto the Blind with Chemical Photoswitches","volume":"118","author":"Tochitsky","year":"2018","journal-title":"Chem.\nRev."},{"issue":"21","key":"2026090312094782200_cit4","doi-asserted-by":"publisher","first-page":"10710","DOI":"10.1021\/acs.chemrev.8b00037","article-title":"In Vivo Photopharmacology","volume":"118","author":"Hu\u0308ll","year":"2018","journal-title":"Chem. Rev."},{"issue":"11","key":"2026090312094782200_cit5","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1002\/anie.201700171","article-title":"Optochemical Control\nof Biological Processes in Cells and Animals","volume":"57","author":"Ankenbruck","year":"2018","journal-title":"Angew. Chem."},{"key":"2026090312094782200_cit6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jconrel.2019.02.006","article-title":"Light-Triggered Release of Photocaged\nTherapeutics - Where Are We Now?","volume":"298","author":"Silva","year":"2019","journal-title":"J. Controlled\nRelease"},{"issue":"9","key":"2026090312094782200_cit7","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41583-019-0197-2","article-title":"Optical Control of Neuronal Ion Channels\nand Receptors","volume":"20","author":"Paoletti","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"24","key":"2026090312094782200_cit8","doi-asserted-by":"publisher","first-page":"13135","DOI":"10.1021\/acs.chemrev.0c00663","article-title":"Visible-to-NIR-Light\nActivated Release: From Small Molecules to Nanomaterials","volume":"120","author":"Weinstain","year":"2020","journal-title":"Chem. Rev."},{"issue":"6716","key":"2026090312094782200_cit9","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn6671","article-title":"Neuromodulator\nand Neuropeptide Sensors\nand Probes for Precise Circuit Interrogation in Vivo","volume":"385","author":"Muir","year":"2024","journal-title":"Science"},{"issue":"24","key":"2026090312094782200_cit10","doi-asserted-by":"publisher","first-page":"5769","DOI":"10.1039\/D4TB00720D","article-title":"Recent Advances in\nStimuli-Responsive Controlled Release Systems for Neuromodulation","volume":"12","author":"Shi","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"2026090312094782200_cit11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41592-023-01819-w","article-title":"In Vivo Photopharmacology with a\nCaged Mu Opioid Receptor\nAgonist Drives Rapid Changes in Behavior","volume":"20","author":"Ma","year":"2023","journal-title":"Nat.\nMethods"},{"key":"2026090312094782200_cit12","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1016\/j.neuron.2023.09.017","article-title":"In Vivo Photopharmacology with Light-Activated Opioid\nDrugs","volume":"111","author":"McClain","year":"2023","journal-title":"Neuron"},{"issue":"12","key":"2026090312094782200_cit13","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.1073\/pnas.1920869117","article-title":"Optofluidic\nControl of Rodent Learning Using Cloaked Caged Glutamate","volume":"117","author":"Durand-de Cuttoli","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026090312094782200_cit14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jconrel.2018.05.033","article-title":"Remote Control of Movement Disorders Using a Photoactive\nAdenosine A2A Receptor Antagonist","volume":"283","author":"Taura","year":"2018","journal-title":"J. Controlled\nRelease"},{"key":"2026090312094782200_cit15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23545","article-title":"Optical Control of Pain in Vivo with\na Photoactive mGlu5 Receptor Negative Allosteric Modulator","volume":"6","author":"Font","year":"2017","journal-title":"eLife"},{"issue":"24","key":"2026090312094782200_cit16","doi-asserted-by":"publisher","first-page":"5203","DOI":"10.1016\/j.cell.2023.10.029","article-title":"Molecular\nBasis of Opioid Receptor Signaling","volume":"186","author":"Che","year":"2023","journal-title":"Cell"},{"issue":"7711","key":"2026090312094782200_cit17","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41586-018-0219-7","article-title":"Structure of the\n\u039c-Opioid Receptor-Gi Protein Complex","volume":"558","author":"Koehl","year":"2018","journal-title":"Nature"},{"issue":"21","key":"2026090312094782200_cit18","doi-asserted-by":"publisher","first-page":"11820","DOI":"10.1073\/pnas.2000712117","article-title":"Biased\nSignaling\nby Endogenous Opioid Peptides","volume":"117","author":"Gomes","year":"2020","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"issue":"677","key":"2026090312094782200_cit19","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aav0320","article-title":"Biased Ligands at\nOpioid Receptors: Current Status and Future Directions","volume":"14","author":"Che","year":"2021","journal-title":"Sci. Signal."},{"issue":"2","key":"2026090312094782200_cit20","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/S0022-3565(25)31350-9","article-title":"The Metabolic Disposition\nof Radiolabeled Enkephalins in Vitro and in Situ","volume":"206","author":"Craves","year":"1978","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090312094782200_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2026.03.025","article-title":"Top-down Control\nof the Descending Pain Modulatory System Drives Multimodal Placebo\nAnalgesia","author":"Livrizzi","year":"2026","journal-title":"Neuron"},{"issue":"2","key":"2026090312094782200_cit22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.neuron.2011.11.016","article-title":"Photoactivatable\nNeuropeptides for Spatiotemporally\nPrecise Delivery of Opioids in Neural Tissue","volume":"73","author":"Banghart","year":"2012","journal-title":"Neuron"},{"issue":"4","key":"2026090312094782200_cit23","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1021\/acschemneuro.7b00485","article-title":"A Caged Enkephalin\nOptimized for\nSimultaneously Probing Mu and Delta Opioid Receptors","volume":"9","author":"Banghart","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"2026090312094782200_cit24","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1124\/mol.113.088096","article-title":"Caged Naloxone\nReveals Opioid Signaling Deactivation Kinetics","volume":"84","author":"Banghart","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"2026090312094782200_cit25","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-1-59745-492-6_5","article-title":"Combining\nUncaging Techniques with Patch-Clamp Recording and Optical Physiology","volume-title":"Patch-Clamp Analysis","author":"Sarkisov","year":"2007"},{"issue":"2","key":"2026090312094782200_cit26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1039\/b504573h","article-title":"Endogenous UVA-Photosensitizers:\nMediators of Skin Photodamage and Novel Targets for Skin Photoprotection","volume":"5","author":"Wondrak","year":"2006","journal-title":"Photochem. Photobiol. Sci."},{"issue":"1","key":"2026090312094782200_cit27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nmeth.f.324","article-title":"Optogenetics","volume":"8","author":"Deisseroth","year":"2011","journal-title":"Nat. Methods"},{"issue":"42","key":"2026090312094782200_cit28","doi-asserted-by":"publisher","first-page":"15948","DOI":"10.1021\/ja408225k","article-title":"Spectral\nEvolution of a Photochemical Protecting Group for Orthogonal Two-Color\nUncaging with Visible Light","volume":"135","author":"Olson","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"38","key":"2026090312094782200_cit29","doi-asserted-by":"publisher","first-page":"10114","DOI":"10.1002\/anie.201405355","article-title":"Sequential Gene\nSilencing Using Wavelength-Selective Caged Morpholino Oligonucleotides","volume":"53","author":"Yamazoe","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"issue":"11","key":"2026090312094782200_cit30","doi-asserted-by":"publisher","first-page":"4970","DOI":"10.1021\/jacs.9b13219","article-title":"Water-Soluble\nBODIPY Photocages with Tunable Cellular Localization","volume":"142","author":"Kand","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"51","key":"2026090312094782200_cit31","doi-asserted-by":"publisher","first-page":"17494","DOI":"10.1002\/chem.201302630","article-title":"Coumarinylmethyl\nCaging Groups with\nRedshifted Absorption","volume":"19","author":"Fournier","year":"2013","journal-title":"Chem. \u2212 Eur. J."},{"issue":"36","key":"2026090312094782200_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202200477","article-title":"Green-Light Activatable\nBODIPY and Coumarin 5\u2032-Caps for Oligonucleotide Photocaging","volume":"28","author":"Kaufmann","year":"2022","journal-title":"Chem. - Eur. J."},{"issue":"30","key":"2026090312094782200_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300390","article-title":"Extending\nthe Palette of Green Coumarin\nPhotocages - Oligonucleotide Fragmentation and Superior 5\u2032-Caps","volume":"29","author":"Kaufmann","year":"2023","journal-title":"Chem. \u2212 Eur. J."},{"issue":"40","key":"2026090312094782200_cit34","doi-asserted-by":"publisher","first-page":"13506","DOI":"10.1039\/D1SC02527A","article-title":"Genetically-Targeted Photorelease\nof Endocannabinoids\nEnables Optical Control of GPR55 in Pancreatic \u03b2-Cells","volume":"12","author":"Tobias","year":"2021","journal-title":"Chem. Sci."},{"issue":"7","key":"2026090312094782200_cit35","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1021\/acschembio.4c00052","article-title":"Optical\nControl of TRPV1 Channels In Vitro with Tethered Photopharmacology","volume":"19","author":"Howe","year":"2024","journal-title":"ACS Chem. Biol."},{"issue":"4","key":"2026090312094782200_cit36","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1021\/acschembio.6b00999","article-title":"Control of an Unusual Photo-Claisen\nRearrangement in\nCoumarin Caged Tamoxifen through an Extended Spacer","volume":"12","author":"Wong","year":"2017","journal-title":"ACS Chem. Biol."},{"issue":"9","key":"2026090312094782200_cit37","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317675","article-title":"Towards a\nLight-Mediated Gene Therapy\nfor the Eye Using Caged Ethinylestradiol and the Inducible Cre\/Lox\nSystem","volume":"63","author":"Kiy","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"issue":"27","key":"2026090312094782200_cit38","doi-asserted-by":"publisher","first-page":"12421","DOI":"10.1021\/jacs.2c04262","article-title":"Strategy for Engineering\nHigh Photolysis Efficiency of Photocleavable Protecting Groups through\nCation Stabilization","volume":"144","author":"Schulte","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090312094782200_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413505","article-title":"Polyanionic Receptors\nfor Carboxylates in Water","volume":"64","author":"Ren","year":"2025","journal-title":"Angew. Chem., Int.\nEd."},{"issue":"5878","key":"2026090312094782200_cit40","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/299074a0","article-title":"Enkephalin Opens Potassium Channels\non Mammalian Central Neurones","volume":"299","author":"Williams","year":"1982","journal-title":"Nature"},{"issue":"36","key":"2026090312094782200_cit41","doi-asserted-by":"publisher","first-page":"19611","DOI":"10.1021\/jacs.3c03913","article-title":"A Biomimetic C-Terminal Extension Strategy for Photocaging\nAmidated Neuropeptides","volume":"145","author":"Layden","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090312094782200_cit42","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0022-3565(25)39250-5","article-title":"Potentiation of\nEnkephalin Action by Peptidase Inhibitors in Rat Locus Ceruleus in\nVitro","volume":"243","author":"Williams","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"2026090312094782200_cit43","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.neuropharm.2012.05.010","article-title":"New Caged Neurotransmitter Analogs\nSelective for Glutamate Receptor Sub-Types Based on Methoxynitroindoline\nand Nitrophenylethoxycarbonyl Caging Groups","volume":"63","author":"Palma-Cerda","year":"2012","journal-title":"Neuropharmacology"},{"issue":"5","key":"2026090312094782200_cit44","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1021\/ja411082f","article-title":"Synthesis and\nBiological Evaluation of Bis-CNB-GABA, a Photoactivatable Neurotransmitter\nwith Low Receptor Interference and Chemical Two-Photon Uncaging Properties","volume":"136","author":"Shi","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090312094782200_cit45","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/anie.201609269","article-title":"Cloaked\nCaged Compounds: Chemical Probes for Two-Photon Optoneurobiology","volume":"56","author":"Richers","year":"2017","journal-title":"Angew. Chem."},{"issue":"2","key":"2026090312094782200_cit46","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1523\/jneurosci.12-02-00483.1992","article-title":"Opioids Excite Dopamine Neurons by Hyperpolarization of Local Interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J. Neurosci."},{"issue":"133","key":"2026090312094782200_cit47","doi-asserted-by":"publisher","first-page":"56774","DOI":"10.3791\/56774","article-title":"An Improved Method\nfor Collection of Cerebrospinal\nFluid from Anesthetized Mice","author":"Lim","year":"2018","journal-title":"J. Vis. Exp. JoVE"},{"issue":"7","key":"2026090312094782200_cit48","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1517\/17425247.2016.1171315","article-title":"CSF, Blood-Brain\nBarrier, and Brain Drug Delivery","volume":"13","author":"Pardridge","year":"2016","journal-title":"Expert Opin.\nDrug Delivery"},{"issue":"10","key":"2026090312094782200_cit49","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1113\/jphysiol.2011.207100","article-title":"In Vivo Two-Photon Uncaging of Glutamate Revealing the Structure-Function\nRelationships of Dendritic Spines in the Neocortex of Adult Mice","volume":"589","author":"Noguchi","year":"2011","journal-title":"J. Physiol."},{"issue":"1","key":"2026090312094782200_cit50","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41467-019-08796-9","article-title":"Rationally Designed Azobenzene Photoswitches for Efficient\nTwo-Photon Neuronal Excitation","volume":"10","author":"Cabre\u0301","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"2026090312094782200_cit51","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuron.2011.06.004","article-title":"Optogenetics\nin Neural Systems","volume":"71","author":"Yizhar","year":"2011","journal-title":"Neuron"},{"issue":"1","key":"2026090312094782200_cit52","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41467-022-27974-w","article-title":"In Vivo Spatiotemporal\nControl of Voltage-Gated Ion Channels by Using Photoactivatable Peptidic\nToxins","volume":"13","author":"Montnach","year":"2022","journal-title":"Nat. Commun."},{"issue":"7","key":"2026090312094782200_cit53","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1111\/bph.15645","article-title":"Remote Local Photoactivation\nof Morphine Produces Analgesia without Opioid-Related Adverse Effects","volume":"180","author":"Lo\u0301pez-Cano","year":"2023","journal-title":"Br. J. Pharmacol."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c15989","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/34\/36359\/66913394\/jacs.6c15989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/34\/36359\/66913394\/jacs.6c15989.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:19:58Z","timestamp":1788452398000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/34\/36359\/5278519\/Photouncaging-of-an-Opioid-Peptide-in-Vivo-Using"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":53,"journal-issue":{"issue":"34","published-online":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c15989","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}