{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:49:52Z","timestamp":1792003792018,"version":"4.4.0"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300421454"],"award-info":[{"award-number":["252300421454"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271256"],"award-info":[{"award-number":["22271256"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A2078"],"award-info":[{"award-number":["U23A2078"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Carboranes are an important class of boron cluster compounds with broad applications in medicine, materials science, and catalysis. However, the site-selective functionalization of their B\u2013H bonds remains a long-standing challenge owing to the nearly identical chemical environments and high bond dissociation energies (BDEs) of these bonds. Traditional approaches generally rely on precious metal catalysts, harsh reaction conditions, or substrate prefunctionalization, which significantly limit their synthetic utility. Herein, we report the first direct B\u2013H\/O\u2013H cross-coupling of o-carboranes with alcohols, enabled by heteroleptic Cu(I) complexes under mild photocatalytic conditions. This protocol achieves highly regioselective B(4)\u2013H alkoxylation with a broad substrate scope and excellent functional group tolerance, providing a facile route to diverse carborane-based building blocks. Mechanistic studies reveal that the benzoyl directing group effectively amplifies the difference in BDEs between B(3)\u2013H and B(4)\u2013H, thereby enabling selective activation of the B(4)\u2013H bond via 1,5-hydrogen atom transfer (HAT). Notably, for the first time, we demonstrate that a boron radical-polar crossover process mediated by the heteroleptic copper catalyst converts boron radicals into highly electrophilic boron cation intermediates, which can be directly trapped by weakly nucleophilic alcohols to form B\u2013O bonds. This work establishes a new and general strategy for carborane B\u2013H functionalization via radical pathways.<\/jats:p>","DOI":"10.1021\/jacs.6c16285","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:01:39Z","timestamp":1790967699000},"page":"43883-43894","source":"Crossref","is-referenced-by-count":0,"title":["Selective B(4)\u2013H\nAlkoxylation of\n                    <i>o<\/i>\n                    -Carboranes with Alcohols\nvia Heteroleptic Cu(I)-Photocatalyzed\n1,5-HAT-Enabled Boron Radical-Polar Crossover"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-1272","authenticated-orcid":true,"given":"Li-Xin","family":"Li","sequence":"first","affiliation":[{"name":"Henan University of Chinese Medicine , , , ,","place":["Zhengzhou, Henan, China, 450046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Teng","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine , , , ,","place":["Zhengzhou, Henan, China, 450046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine , , , ,","place":["Zhengzhou, Henan, China, 450046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , , ,","place":["Zhengzhou, Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine , , , ,","place":["Zhengzhou, Henan, China, 450046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-062X","authenticated-orcid":true,"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine , , , ,","place":["Zhengzhou, Henan, China, 450046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-6792","authenticated-orcid":true,"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , , ,","place":["Zhengzhou, Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9029-1777","authenticated-orcid":true,"given":"Xuenian","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , , ,","place":["Zhengzhou, Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-1851","authenticated-orcid":true,"given":"Yan-Na","family":"Ma","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , , ,","place":["Zhengzhou, Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"2026101414080956800_cit1a","doi-asserted-by":"publisher","first-page":"7035","DOI":"10.1021\/cr200038x","article-title":"Carbaboranes as Pharmacophores: Properties,\nSynthesis, and Application Strategies","volume":"111","author":"Scholz","year":"2011","journal-title":"Chem.\nRev."},{"key":"2026101414080956800_cit1b","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.1039\/C9CS00197B","article-title":"New Keys for Old Locks: Carborane-containing\nDrugs as Platforms for Mechanism-based Therapies","volume":"48","author":"Stockmann","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"2026101414080956800_cit1c","doi-asserted-by":"publisher","first-page":"14335","DOI":"10.1002\/chem.202002963","article-title":"Bimodal Therapeutic Agents Against Glioblastoma, One\nof the Most Lethal Forms of Cancer","volume":"26","author":"Couto","year":"2020","journal-title":"Chem. Eur.\nJ."},{"key":"2026101414080956800_cit1d","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41570-022-00400-x","article-title":"Carboranes in Drug\nDiscovery, Chemical Biology and Molecular Imaging","volume":"6","author":"Marfavi","year":"2022","journal-title":"Nat. Rev. Chem."},{"key":"2026101414080956800_cit1e","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1021\/acs.chemrev.3c00663","article-title":"The Rise of Boron-Containing\nCompounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging\nPharmacology","volume":"124","author":"Grams","year":"2024","journal-title":"Chem. Rev."},{"key":"2026101414080956800_cit2a","doi-asserted-by":"publisher","first-page":"9396","DOI":"10.1021\/jacs.0c02228","article-title":"Too Persistent to Give Up: Aromaticity\nin Boron Clusters Survives Radical Structural Changes","volume":"142","author":"Poater","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit2b","doi-asserted-by":"publisher","first-page":"6558","DOI":"10.1021\/jacs.2c01668","article-title":"Highly\nSelective Separation of Benzene and Cyclohexane in a Spatially Confined\nCarborane Metallacage","volume":"144","author":"Cui","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit2c","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1039\/D3SC06222H","article-title":"Molecular engineering of AIE-active\nboron clustoluminogens for enhanced boron neutron capture therapy","volume":"15","author":"Ma","year":"2024","journal-title":"Chem. Sci."},{"key":"2026101414080956800_cit2d","doi-asserted-by":"publisher","first-page":"24430","DOI":"10.1021\/jacs.5c03381","article-title":"Chirality-Contiguous\nBridged Carboranes: Synergistic Scalable Synthesis and Amplification\nof Circularly Polarized Luminescence","volume":"147","author":"Nan","year":"2025","journal-title":"J. Am.\nChem. Soc."},{"key":"2026101414080956800_cit2e","doi-asserted-by":"publisher","first-page":"26736","DOI":"10.1021\/jacs.6c07624","article-title":"Evidence for Delocalization between o-Carborane and Triphenylethylene via an Alkynyl Bridge","volume":"148","author":"Li","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit3a","doi-asserted-by":"publisher","first-page":"9842","DOI":"10.1021\/jacs.1c03568","article-title":"Carborane Stabilized \u201c19-Electron\u201d\nMolybdenum Metalloradical","volume":"143","author":"Jaiswal","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit3b","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1039\/D1SC07070C","article-title":"Selective Electrochemical Capture\nand Release of Uranyl from Aqueous Alkali, Lanthanide, and Actinide\nMixtures Using Redox-switchable Carboranes","volume":"13","author":"Keener","year":"2022","journal-title":"Chem. Sci."},{"key":"2026101414080956800_cit3c","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1016\/j.cclet.2021.12.016","article-title":"Recent Advances on Carborane-based\nLigands in Low-valent Group 13 and Group 14 Elements Chemistry","volume":"33","author":"Wang","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"2026101414080956800_cit3d","doi-asserted-by":"publisher","first-page":"23458","DOI":"10.1021\/jacs.4c17482","article-title":"Quantum Hydrogen\nTunneling in an Iridium Dihydride Complex","volume":"147","author":"Hamdaoui","year":"2025","journal-title":"J.\nAm. Chem. Soc."},{"key":"2026101414080956800_cit4a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212073","article-title":"Tris(ortho-carboranyl)borane: An Isolable, Halogen-Free, Lewis\nSuperacid","volume":"61","author":"Akram","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit4b","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41929-022-00888-y","article-title":"Boron-Catalysed\nHydrogenolysis of Unactivated C(aryl)-C(alkyl) bonds","volume":"6","author":"Xu","year":"2023","journal-title":"Nat. Catal."},{"key":"2026101414080956800_cit4c","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/s41557-024-01569-y","article-title":"Hydrogen Splitting\nat a Single Phosphorus Centre and Its Use for Hydrogenation","volume":"16","author":"Bawari","year":"2024","journal-title":"Nat. Chem."},{"key":"2026101414080956800_cit4d","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1021\/acs.orglett.5c04669","article-title":"Triarylboranes\nBearing (ortho-Carboran-1-yl)aryl Groups for Catalytic\nHydrogenation with Pure or Crude H2","volume":"28","author":"Hisata","year":"2026","journal-title":"Org. Lett."},{"key":"2026101414080956800_cit5a","doi-asserted-by":"publisher","first-page":"7662","DOI":"10.1002\/anie.201502502","article-title":"Nickel-Catalyzed Cross-Coupling Reactions\nof o-Carboranyl with Aryl Iodides: Facile Synthesis\nof 1-Aryl-o-Carboranes and 1,2-Diaryl-o-Carboranes","volume":"54","author":"Tang","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit5b","doi-asserted-by":"publisher","first-page":"18661","DOI":"10.1021\/jacs.0c08652","article-title":"Transition-Metal-Free\nCross-Coupling Reaction of Iodocarboranes with Terminal Alkynes Enabled\nby UV Light: Synthesis of 1-Alkynyl-o-Carboranes\nand Carborane-Fused Cyclics","volume":"142","author":"Ni","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit5c","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1039\/D2CS00024E","article-title":"Functionalization of o-Carboranes\nvia Carboryne Intermediates","volume":"51","author":"Qiu","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"2026101414080956800_cit5d","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305088","article-title":"Visible-Light-Induced Photoreduction\nof Carborane Phosphonium Salts: Efficient Synthesis of Carborane-Oxindole-Pharmaceutical\nHybrids","volume":"62","author":"Liu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit5e","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1021\/acs.orglett.4c00489","article-title":"Breaking the Base Barrier: Cu(II)-Mediated\nC-H Heteroarylation of o-Carboranes with Base-Sensitive\nHeteroaryl Halides","volume":"26","author":"Sun","year":"2024","journal-title":"Org. Lett."},{"key":"2026101414080956800_cit5f","doi-asserted-by":"publisher","first-page":"37677","DOI":"10.1021\/jacs.5c13004","article-title":"An Isolated\nLithium ortho-Carboranyl Cuprate Complex for the\nSynthesis of Multiple-Carborane-Substituted Arenes from (Hetero)Aryl\nBromides and Chlorides","volume":"147","author":"Hisata","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit5g","doi-asserted-by":"publisher","first-page":"6732","DOI":"10.1021\/acs.orglett.5c01838","article-title":"Photocatalyzed Oxycarboranylation\nof Alkenes with 1-Iodo-o-carboranes through a Halogen-Atom\nTransfer Strategy","volume":"27","author":"Li","year":"2025","journal-title":"Org. Lett."},{"key":"2026101414080956800_cit5h","doi-asserted-by":"publisher","first-page":"9173","DOI":"10.1021\/acs.orglett.5c02604","article-title":"Photocatalyzed Oxycarboranylation\nand Hydrocarboranylation of Unsaturated C-C Bonds with 1-Iodo-2-methyl-o-carboranes as the Synthon","volume":"27","author":"Li","year":"2025","journal-title":"Org.\nLett."},{"key":"2026101414080956800_cit5i","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1021\/acs.orglett.6c00761","article-title":"Photoexcited\nCopper-Catalyzed Atom Transfer Radical Addition (ATRA) Reaction of\nUnsaturated C-C Bonds with 1-Iodo-o-carboranes","volume":"28","author":"Chen","year":"2026","journal-title":"Org. Lett."},{"key":"2026101414080956800_cit5j","doi-asserted-by":"publisher","first-page":"10308","DOI":"10.1021\/jacs.5c18673","article-title":"Copper(I)-Mediated\nDirect C-H Functionalization of Carborane Anion: One-Pot Installation\nof Amino, Hydroxyl, Carbon, and Other Heteroatom Functional Groups\nat the C1 Vertex","volume":"148","author":"Kitazawa","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit5k","doi-asserted-by":"publisher","first-page":"7194","DOI":"10.1039\/D5SC10093C","article-title":"Stereospecific Alkenylation\nof Carboranes: Copper-catalyzed Access to Pyridylcarboranyl Alkenes","volume":"17","author":"Li","year":"2026","journal-title":"Chem. Sci."},{"key":"2026101414080956800_cit6a","first-page":"2795","article-title":"Transition-Metal-Catalyzed\nSelective Cage B\u2013H Functionalization of o-Carboranes","volume":"24","author":"Quan","year":"2018","journal-title":"Chem.\u2500Eur. J."},{"key":"2026101414080956800_cit6b","doi-asserted-by":"publisher","first-page":"3660","DOI":"10.1039\/C9CS00169G","article-title":"Controlled Functionalization of o-Carborane via\nTransition Metal Catalyzed B-H Activation","volume":"48","author":"Quan","year":"2019","journal-title":"Chem.\nSoc. Rev."},{"key":"2026101414080956800_cit6c","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.ccr.2017.11.006","article-title":"Transition Metal-induced\nB-H Functionalization of o-Carborane","volume":"378","author":"Zhang","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"2026101414080956800_cit6d","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1021\/acs.accounts.1c00460","article-title":"A Strategy for Selective Catalytic B-H Functionalization of o-Carboranes","volume":"54","author":"Qiu","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"2026101414080956800_cit7a","doi-asserted-by":"publisher","first-page":"9081","DOI":"10.1021\/jacs.6b05505","article-title":"B-O, and B-CN Bond Formation via Palladium-Catalyzed\nCross-Coupling of B-Bromo-Carboranes","volume":"138","author":"Dziedzic","year":"2016","journal-title":"J. Am.\nChem. Soc."},{"key":"2026101414080956800_cit7b","doi-asserted-by":"publisher","first-page":"7729","DOI":"10.1021\/jacs.7b04080","article-title":"Cage-Walking:\nVertex Differentiation by Palladium-Catalyzed Isomerization of B(9)-Bromo-meta-Carborane","volume":"139","author":"Dziedzic","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit7c","doi-asserted-by":"publisher","first-page":"4508","DOI":"10.1021\/jacs.8b01754","article-title":"Enantioselective Synthesis\nof Chiral-at-Cage o-Carboranes via Pd-Catalyzed Asymmetric B-H Substitution","volume":"140","author":"Cheng","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit7d","doi-asserted-by":"publisher","first-page":"19007","DOI":"10.1002\/anie.201910568","article-title":"A 3D Analogue of Phenyllithium: Solution-Phase,\nSolid-State, and Computational Study of the Lithiacarborane [Li\u2013CB11H11]\u2212","volume":"58","author":"Dontha","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit7e","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.1021\/jacs.1c00593","article-title":"Ir-Catalyzed Selective\nB(3)-H Amination of o-Carboranes with NH3","volume":"143","author":"Au","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit7f","doi-asserted-by":"publisher","first-page":"8371","DOI":"10.1021\/jacs.2c03031","article-title":"Palladium-Catalyzed\nRegioselective B(9)-Amination of o-Carboranes and m-Carboranes in HFIP with Broad Nitrogen Sources","volume":"144","author":"Ma","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit7g","doi-asserted-by":"publisher","first-page":"43946","DOI":"10.1021\/jacs.5c16451","article-title":"Direct B-H Bond Activation\nPolymerization of Boron Clusters","volume":"147","author":"Chen","year":"2025","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026101414080956800_cit7h","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416987","article-title":"Asymmetric Palladium Migration for Synthesis of Chiral-at-Cage o-Carboranes","volume":"64","author":"Guo","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit7i","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1038\/s41467-025-59410-0","article-title":"Site- and Enantioselective B\u2013H\nFunctionalization of Carboranes","volume":"16","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"key":"2026101414080956800_cit7j","doi-asserted-by":"publisher","first-page":"7646","DOI":"10.1021\/acscatal.5c01516","article-title":"Polyoxometalate-Supported Pd(II)-Catalyzed B(9)-H Nitration of o\/m-Carboranes","volume":"15","author":"Wang","year":"2025","journal-title":"ACS\nCatal."},{"key":"2026101414080956800_cit7k","doi-asserted-by":"publisher","first-page":"27030","DOI":"10.1021\/jacs.5c09523","article-title":"Precise Distal B-H Bond Activation\nof nido-Carboranes by Copper Catalysis: Synthesis\nof Benzene Bioisosteres from Boron Clusters","volume":"147","author":"Zhou","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit7l","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41929-026-01480-4","article-title":"Palladium-catalysed Asymmetric anti-Michael-type\nAddition of \u03b1,\u03b2-Unsaturated Carboxylic\nAcids with Carboranes","volume":"9","author":"Lei","year":"2026","journal-title":"Nat. Catal."},{"key":"2026101414080956800_cit7m","doi-asserted-by":"publisher","first-page":"103008","DOI":"10.1016\/j.chempr.2026.103008","article-title":"B\u2013H Oxidation Enables Modular\nSynthesis of Vicinally Trifunctionalized Boron-rich Clusters","volume":"12","author":"Zhu","year":"2026","journal-title":"Chem"},{"key":"2026101414080956800_cit7n","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1021\/acscatal.5c08932","article-title":"Palladium-Catalyzed Asymmetric B-H Arylation of o-Carboranes Assisted by a Chiral Transient Directing Group","volume":"16","author":"Zou","year":"2026","journal-title":"ACS Catal."},{"key":"2026101414080956800_cit7o","doi-asserted-by":"publisher","first-page":"25186","DOI":"10.1021\/jacs.6c07496","article-title":"Pd-Catalyzed Facile and Selective\nB\u2013H Carbonylation Leading to Boron Cluster Carboxylic Acids\nfor Diverse Transformations","volume":"148","author":"Liu","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit8a","doi-asserted-by":"publisher","first-page":"7331","DOI":"10.1021\/jacs.2c13570","article-title":"B(9)-OH-o-Carboranes:\nSynthesis, Mechanism, and Property Exploration","volume":"145","author":"Ma","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit8b","doi-asserted-by":"publisher","first-page":"26543","DOI":"10.1021\/jacs.4c10728","article-title":"Dative Bonding Activation Enables\nPrecise Functionalization of the Remote B-H Bond of nido-Carborane Clusters","volume":"146","author":"Ren","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit9a","first-page":"1440","article-title":"Electrophile-Induced\nNucleophilic Substitution of the nido-Dicarbaundecaborate\nAnion nido-7,8-C2B9H12\u2013 by Conjugated Heterodienes","volume":"20","author":"Frank","year":"2014","journal-title":"Chem.\u2500Eur.\nJ."},{"key":"2026101414080956800_cit9b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202202675","article-title":"N-Ligand-Enabled\nAromatic Nucleophilic Amination of 1,2-Diaryl-o-Carboranes\nwith (R2N)2Mg for Selective Synthesis of 4-R2N-o-Carboranes and 2-R2N-m-Carboranes","volume":"61","author":"Zhang","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit9c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.8959071","article-title":"Migration at Boron Cage for Selective\nB\u2013H Functionalization of nido -Carboranes","volume":"65","author":"Zhang","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit10","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1039\/D3QO00621B","article-title":"A Strategy for Regioselective B-H Functionalization of o-Carboranes via Base Metal Catalysis","volume":"10","author":"Zhang","year":"2023","journal-title":"Org.\nChem. Front."},{"key":"2026101414080956800_cit11a","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1021\/jacs.0c00300","article-title":"Oxidative Generation\nof Boron-Centered Radicals in\nCarboranes","volume":"142","author":"Mills","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit11b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205672","article-title":"Site-Selective\nFunctionalization of Carboranes at the Electron-Rich Boron Vertex:\nPhotocatalytic B\u2013C Coupling via a Carboranyl Cage Radical","volume":"61","author":"Chen","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit11c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202504793","article-title":"closo-Carboranyl Analogs of \u03b2-Arylethylamines:\nDirect Synthesis from Alkenes via EnT-Catalysis","volume":"64","author":"Paulus","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit11d","doi-asserted-by":"publisher","first-page":"16618","DOI":"10.1021\/jacs.6c04797","article-title":"Visible-Light-Promoted\nNickel-Catalyzed Cross-Coupling of Iodocarboranes with Triarylarsanes\nand Triphenylstibanes","volume":"148","author":"Wang","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit11e","doi-asserted-by":"publisher","first-page":"17333","DOI":"10.1021\/jacs.6c03550","article-title":"Electrochemical Synthesis of Boron-Centered\nCarboranyl Radical for Modular Carboranyl N-Heterocycles","volume":"148","author":"Zhou","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit12","doi-asserted-by":"publisher","first-page":"7638","DOI":"10.1021\/jacs.3c01314","article-title":"Direct B\u2013H Functionalization\nof Icosahedral Carboranes via Hydrogen Atom Transfer","volume":"145","author":"Ren","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit13","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1021\/jacs.5c20945","article-title":"Direct B\u2013H Activation of Carborane Clusters via Synergistic\nLMCT and HAT Photocatalysis","volume":"148","author":"Ren","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit14","doi-asserted-by":"publisher","first-page":"6940","DOI":"10.1021\/jacs.0c02490","article-title":"Copper-Catalyzed Electrochemical\nSelective B\u2013H Oxygenation of o-Carboranes\nat Room Temperature","volume":"142","author":"Au","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit15a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202516794","article-title":"Hydroalkylation of\nUnactivated Alkenes with Amides via Photoredox Catalysis and Triple\nHydrogen Atom Transfer","volume":"64","author":"Yi","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit15b","doi-asserted-by":"publisher","first-page":"29367","DOI":"10.1021\/jacs.5c09218","article-title":"Directed Halogen Atom Transfer (DIXAT): A Powerful\nTool for Chemoselective Generation of Aryl Radicals Toward Remote\nC(sp3)\u2013H Functionalization of Aliphatic Amines","volume":"147","author":"Wagulde","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit15c","doi-asserted-by":"publisher","first-page":"40064","DOI":"10.1021\/jacs.5c12618","article-title":"Transition-Metal-Free\nSite-Selective \u03b2- and \u03b1-C\u2013H Borylation of Aliphatic Amines","volume":"147","author":"Sarkar","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit15d","doi-asserted-by":"publisher","first-page":"40010","DOI":"10.1021\/jacs.5c16924","volume":"147","author":"Zhang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit15e","doi-asserted-by":"publisher","first-page":"29830","DOI":"10.1021\/jacs.6c04253","article-title":"Photoinduced Copper-Catalzyed\nSite- and Stereoselective Desymmetrizing \u03b2-\nC(sp3)\u2013H Alkynylation of Cycloalkyl Amines","volume":"148","author":"Pan","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit15f","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1039\/D5QO01746G","article-title":"Remote C(sp3)-H Cyanation\nand Deuteration of Amides via Photoredox Catalysis","volume":"13","author":"Yan","year":"2026","journal-title":"Org. Chem. Front."},{"key":"2026101414080956800_cit16a","doi-asserted-by":"publisher","first-page":"26629","DOI":"10.1021\/jacs.6c07376","article-title":"Late-Stage Carboranylation of Nucleos(t)ides\nEnabled by Minisci and Pd-Catalyzed B-N Cross-Coupling Reactions:\nToward the Synthesis of Carbonyl-Modified Oligonucleotides","volume":"148","author":"Zhou","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit16b","doi-asserted-by":"publisher","first-page":"38233","DOI":"10.1021\/jacs.6c11012","article-title":"Synthesis of Carborane-Modified Sugars and Nucleosides via Pd(II)-Catalyzed\nB-H Bond Activation","volume":"148","author":"Huang","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit17","doi-asserted-by":"publisher","first-page":"102788","DOI":"10.1016\/j.chempr.2025.102788","article-title":"Robust B\u2013H\nPerdeuteration of Polyhedral Boron Clusters with D2O by\nPd(II)-catalytic Electrophilic H\/D exchange and Intermolecular Pd\nmigration","volume":"12","author":"Liang","year":"2026","journal-title":"Chem"},{"key":"2026101414080956800_cit18","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1515\/pac-2014-0502","volume":"87","author":"Armstrong","year":"2015","journal-title":"Pure Appl. Chem."},{"key":"2026101414080956800_cit19a","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1002\/anie.201800144","article-title":"Heteroleptic Copper(I)-Based Complexes\nfor Photocatalysis: Combinatorial Assembly, Discovery, and Optimization","volume":"57","author":"Minozzi","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026101414080956800_cit19b","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41929-025-01357-y","article-title":"A General Photocatalytic Platform for the Regio- and\nStereoselective \u03b2-Chloroacylation of Alkenes\nand Alkynes Using a Heteroleptic Copper(I) Complex","volume":"8","author":"Mandal","year":"2025","journal-title":"Nat. Catal."},{"key":"2026101414080956800_cit20","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1039\/C6SC01566B","article-title":"[3-N2-o-C2B10H11][BF4]: A Useful\nSynthon for Multiple Cage Boron\nFunctionalization of o-Carborane","volume":"7","author":"Zhao","year":"2016","journal-title":"Chem. Sci."},{"key":"2026101414080956800_cit21a","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1039\/D1CC05850A","article-title":"The Advent and Development of Organophotoredox Catalysis","volume":"58","author":"Bortolato","year":"2022","journal-title":"Chem. Commun."},{"key":"2026101414080956800_cit21b","doi-asserted-by":"publisher","first-page":"31680","DOI":"10.1021\/jacs.6c06459","article-title":"Photocatalytic DenitrativeHomo-\nand Cross-Couplingof Nitroalkanes toward the Synthesis of Alkenes","volume":"148","author":"Dietel","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414080956800_cit22a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202219086","article-title":"Copper(I)\nPhotocatalyzed Bromonitroalkylation of Olefins: Evidence for Highly\nEfficient Inner-Sphere Pathways","volume":"62","author":"Reichle","year":"2023","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026101414080956800_cit22b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202509658","article-title":"Copper(II)-Photocatalyzed\nRadical Anellation of Nitroalkanes with Alkenes or Alkynes for the\nSynthesis of Isoxazolines and Isoxazoles","volume":"64","author":"Sardana","year":"2025","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026101414080956800_cit22c","doi-asserted-by":"publisher","first-page":"17751","DOI":"10.1021\/acscatal.5c05213","article-title":"1,2-Aminosulfonylation\nof Alkenes via a Photoexcited Cu(I)-Substrate Complex: A Three-Component\nCoupling Approach","volume":"15","author":"Das","year":"2025","journal-title":"ACS Catal."},{"key":"2026101414080956800_cit23","doi-asserted-by":"publisher","first-page":"14625","DOI":"10.1021\/acscatal.6c03087","article-title":"Visible-Light-Mediated\nPyridine-N-oxide-Assisted Alkoxycarbonyl Chlorination\nof Alkenes via Iron-Catalyzed Radical Ligand Transfer","volume":"16","author":"Ghosh","year":"2026","journal-title":"ACS Catal."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c16285","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/40\/43883\/68737924\/jacs.6c16285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/40\/43883\/68737924\/jacs.6c16285.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:23:13Z","timestamp":1792002193000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/40\/43883\/5444095\/Selective-B-4-H-Alkoxylation-of-o-Carboranes-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":81,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2026,10,2]]},"published-print":{"date-parts":[[2026,10,14]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c16285","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]}}}