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However, the process by which multimetallic nanoparticles form in SPBCL-patterned nanoreactors remains unclear. Here, we utilize the combination of PEO-b-P2VP and Au, Ag, and Cu salts as a model three-component system to investigate this process. The data suggest that the formation of single-component Au, Ag, or Cu nanoparticles within polymer nanoreactors consists of two stages: (I) nucleation, growth, and coarsening of the particles to yield a single particle in each reactor; (II) continued particle growth by depletion of the remaining precursor in the reactor until the particle reaches a stable size. Also, different aggregation rates are observed for single-component particle formation (Au &amp;gt; Ag &amp;gt; Cu). This behavior is also observed for two-component systems, where nucleation sites have greater Au content than the other metals. This information can be used to trap nanoparticles with kinetic structures. High-temperature treatment ultimately facilitates the structural evolution of the kinetic particle into a particle with a fixed structure. Therefore, with multicomponent systems, a third stage that involves elemental redistribution within the particle must be part of the description of the synthetic process. This work not only provides a glimpse at the mechanism underlying multicomponent nanoparticle formation in SPBCL-generated nanoreactors but also illustrates, for the first time, the utility of SPBCL as a platform for controlling the architectural evolution of multimetallic nanoparticles in general.<\/jats:p>","DOI":"10.1021\/jacs.7b03163","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T16:34:11Z","timestamp":1499877251000},"page":"9876-9884","source":"Crossref","is-referenced-by-count":59,"title":["Structural\nEvolution of Three-Component Nanoparticles\nin Polymer Nanoreactors"],"prefix":"10.1021","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-9549","authenticated-orcid":true,"given":"Peng-Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-6699","authenticated-orcid":true,"given":"Jingshan S.","family":"Du","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Meckes","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-7141","authenticated-orcid":true,"given":"Zhuang","family":"Xie","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Hedrick","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-3063","authenticated-orcid":true,"given":"Vinayak P.","family":"Dravid","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-7627","authenticated-orcid":true,"given":"Chad A.","family":"Mirkin","sequence":"additional","affiliation":[{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]},{"name":"Northwestern University , , , , ,","place":["Evanston, Illinois, United States, 60208"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"2026090305055523200_cit1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1021\/nl304448p","volume":"13","author":"George","year":"2013","journal-title":"Nano Lett."},{"key":"2026090305055523200_cit2","doi-asserted-by":"publisher","first-page":"4792","DOI":"10.1038\/ncomms5792","volume":"5","author":"Weng","year":"2014","journal-title":"Nat. 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