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However, the short half-lives of the currently used radionuclides 11C (20.4 min) and 18F (109.8 min) may limit the widespread use of these imaging agents. Therefore, we have begun to evaluate novel AD diagnostic agents that can be radiolabeled with 64Cu, a radionuclide with a half-life of 12.7 h, ideal for PET imaging. Described herein are a series of bifunctional chelators (BFCs), L1\u2013L5, that were designed to tightly bind 64Cu and shown to interact with A\u03b2 aggregates both in vitro and in transgenic AD mouse brain sections. Importantly, biodistribution studies show that these compounds exhibit promising brain uptake and rapid clearance in wild-type mice, and initial microPET imaging studies of transgenic AD mice suggest that these compounds could serve as lead compounds for the development of improved diagnostic agents for AD.<\/jats:p>","DOI":"10.1021\/jacs.7b05937","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T01:40:08Z","timestamp":1503279608000},"page":"12550-12558","source":"Crossref","is-referenced-by-count":76,"title":["Evaluation\nof 64Cu-Based Radiopharmaceuticals\nthat Target A\u03b2 Peptide Aggregates as Diagnostic Tools for Alzheimer\u2019s\nDisease"],"prefix":"10.1021","volume":"139","author":[{"given":"Nilantha","family":"Bandara","sequence":"first","affiliation":[{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63110"]},{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Washington University , , One Brookings Drive , , ,","place":["St. Louis, Missouri, United States, 63130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Krieger","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Washington University , , One Brookings Drive , , ,","place":["St. Louis, Missouri, United States, 63130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Hee","family":"Han","sequence":"additional","affiliation":[{"name":"A.T. Still University of Health Sciences, Kirksville College of Osteopathic Medicine , , , ,","place":["Kirksville, Missouri, United States, 63501"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buck E.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63110"]},{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-9508","authenticated-orcid":true,"given":"Liviu M.","family":"Mirica","sequence":"additional","affiliation":[{"name":"Washington University , , One Brookings Drive , , ,","place":["St. Louis, Missouri, United States, 63130"]},{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63110"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"2026090114373652800_cit1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrd2896","volume":"9","author":"Citron","year":"2010","journal-title":"Nat. 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