{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:51:31Z","timestamp":1787161891216,"version":"build-2736575974"},"reference-count":24,"publisher":"American Chemical Society (ACS)","issue":"42","funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["F-1896"],"award-info":[{"award-number":["F-1896"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM059796"],"award-info":[{"award-number":["GM059796"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2017,10,25]]},"DOI":"10.1021\/jacs.7b07419","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T05:09:43Z","timestamp":1507698583000},"page":"14837-14840","source":"Crossref","is-referenced-by-count":29,"title":["The Impact of Protonation on Early Translocation of Anthrax Lethal Factor: Kinetics from Molecular Dynamics Simulations and Milestoning Theory"],"prefix":"10.1021","volume":"139","author":[{"given":"Piao","family":"Ma","sequence":"first","affiliation":[{"name":"Department\rof Chemistry, University of Texas at Austin, Austin, Texas 78712, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo E.","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Institute\rfor Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas 78712, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangesh I.","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Biological\rand Engineering Sciences, Sandia National Laboratories, Albuquerque, New Mexico 87185, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-415X","authenticated-orcid":true,"given":"Ron","family":"Elber","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Texas at Austin, Austin, Texas 78712, United States"},{"name":"Institute\rfor Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas 78712, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1623-2108","authenticated-orcid":true,"given":"Susan B.","family":"Rempe","sequence":"additional","affiliation":[{"name":"Biological\rand Engineering Sciences, Sandia National Laboratories, Albuquerque, New Mexico 87185, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142728"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14247"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1113380"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/n35101998"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.11.030"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905880106"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.050864"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405754101"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2052"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600624113"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1923"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583517000063"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1063\/1.3129843"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ct100114j"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.02.005"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ct100578z"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh381"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.6b01853"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.058727"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1063\/1.4913399"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/science.109563"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008309200"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.7b07419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T16:42:41Z","timestamp":1682440961000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.7b07419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":24,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2017,10,25]]}},"alternative-id":["10.1021\/jacs.7b07419"],"URL":"https:\/\/doi.org\/10.1021\/jacs.7b07419","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]}}}