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Here we present a detailed biophysical study on the behavior of dynamic SCPNs in living cells and an evaluation of their catalytic functionality in such a complex medium. We first developed a number of delivery strategies that allowed the selective localization of SCPNs in different cellular compartments. Live\/dead tests showed that the SCPNs were not toxic to cells while spectral imaging revealed that SCPNs provide a structural shielding and reduced the influence from the outer biological media. The ability of SCPNs to act as catalysts in biological media was first assessed by investigating their potential for reactive oxygen species generation. With porphyrins covalently attached to the SCPNs, singlet oxygen was generated upon irradiation with light, inducing spatially controlled cell death. In addition, Cu(I)- and Pd(II)-based SCPNs were prepared and these catalysts were screened in vitro and studied in cellular environments for the carbamate cleavage reaction of rhodamine-based substrates. This is a model reaction for the uncaging of bioactive compounds such as cytotoxic drugs for catalysis-based cancer therapy. We observed that the rate of the deprotection depends on both the organometallic catalysts and the nature of the protective group. The rate reduces from in vitro to the biological environment, indicating a strong influence of biomolecules on catalyst performance. The Cu(I)-based SCPNs in combination with the dimethylpropargyloxycarbonyl protective group showed the best performances both in vitro and in biological environment, making this group promising in biomedical applications.<\/jats:p>","DOI":"10.1021\/jacs.8b00122","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T07:08:10Z","timestamp":1519024090000},"page":"3423-3433","source":"Crossref","is-referenced-by-count":208,"title":["Catalytically\nActive Single-Chain Polymeric Nanoparticles:\nExploring Their Functions in Complex Biological Media"],"prefix":"10.1021","volume":"140","author":[{"given":"Yiliu","family":"Liu","sequence":"first","affiliation":[{"name":"Eindhoven University of Technology , , P.O. Box 513, ,","place":["Eindhoven, The Netherlands, 5600 MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u0301lvia","family":"Pujals","sequence":"additional","affiliation":[{"name":"The Barcelona Institute of Science and Technology , , Carrer de Baldiri Reixac 15-21 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J. M.","family":"Stals","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , P.O. Box 513, ,","place":["Eindhoven, The Netherlands, 5600 MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Paulo\u0308hrl","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , P.O. Box 513, ,","place":["Eindhoven, The Netherlands, 5600 MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav I.","family":"Presolski","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , P.O. Box 513, ,","place":["Eindhoven, The Netherlands, 5600 MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-7492","authenticated-orcid":true,"given":"E. W.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , P.O. 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