{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:17:56Z","timestamp":1790533076271,"version":"4.1.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["705529"],"award-info":[{"award-number":["705529"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"publisher","award":["291803"],"award-info":[{"award-number":["291803"]}],"id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["2014-16823"],"award-info":[{"award-number":["2014-16823"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["24432"],"award-info":[{"award-number":["24432"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007486","name":"Universit\u00e9 Paris-Sud","doi-asserted-by":"publisher","award":["2010\u201325"],"award-info":[{"award-number":["2010\u201325"]}],"id":[{"id":"10.13039\/501100007486","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poisoning and accidental oral intoxication are major health problems worldwide. Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal\u2013organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. Furthermore, the in vivo toxicity and biodistribution of a MOF via oral administration have been investigated for the first time. Orally administered upon a salicylate overdose, this MOF is able to reduce the salicylate gastrointestinal absorption and toxicity more than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (&amp;lt;9% degradation), poor intestinal permeation, and safety.<\/jats:p>","DOI":"10.1021\/jacs.8b04435","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T14:42:32Z","timestamp":1531233752000},"page":"9581-9586","source":"Crossref","is-referenced-by-count":99,"title":["Metal\u2013Organic\nFrameworks as Efficient Oral\nDetoxifying Agents"],"prefix":"10.1021","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-2122","authenticated-orcid":true,"given":"Sara","family":"Rojas","sequence":"first","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , 45 Av. Des Etats Unis , ,","place":["Versailles, France, 78035 Cedex"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Baati","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , 45 Av. Des Etats Unis , ,","place":["Versailles, France, 78035 Cedex"]},{"name":"Institut National de Recherche et d\u2019Analyse Physico-Chimique (INRAP), BiotechPole Sidi Thabet , , , ,","place":["Sidi Thabet, Ariana, Tunisie, 2020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Njim","sequence":"additional","affiliation":[{"name":"CHU de Monastir , , ,","place":["Monastir, Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Manchego","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , 45 Av. Des Etats Unis , ,","place":["Versailles, France, 78035 Cedex"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadoua","family":"Neffati","sequence":"additional","affiliation":[{"name":"CHU de Monastir , , ,","place":["Monastir, Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissem","family":"Abdeljelil","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , 45 Av. Des Etats Unis , ,","place":["Versailles, France, 78035 Cedex"]},{"name":"Universite\u0301 de Sousse , , ,","place":["Sousse, Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Saguem","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Sousse , , ,","place":["Sousse, Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Serre","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , 45 Av. Des Etats Unis , ,","place":["Versailles, France, 78035 Cedex"]},{"name":"PSL Research University , , 24 rue Lhomond , ,","place":["Paris, France, 75005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Fadhel","family":"Najjar","sequence":"additional","affiliation":[{"name":"CHU de Monastir , , ,","place":["Monastir, Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelfateh","family":"Zakhama","sequence":"additional","affiliation":[{"name":"CHU de Monastir , , ,","place":["Monastir, Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-5911","authenticated-orcid":true,"given":"Patricia","family":"Horcajada","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , 45 Av. Des Etats Unis , ,","place":["Versailles, France, 78035 Cedex"]},{"name":"IMDEA Energy Institute , . Av. Ramo\u0301n de la Sagra 3 , ,","place":["Mo\u0301stoles-Madrid, Spain, 28935"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"2026090217383956800_cit1","unstructured":"Poison\nStatistics: National Data 2016. http:\/\/www.poison.org\/poison-statistics-national (accessed May 5, 2018)."},{"key":"2026090217383956800_cit2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/qjmed\/93.11.715","article-title":"Patterns and\nProblems of Deliberate Self-Poisoning in the Developing World","volume":"93","author":"Eddleston","year":"2000","journal-title":"QJM"},{"key":"2026090217383956800_cit3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.2217\/nnm.11.75","article-title":"Nanodetoxification: Emerging Role\nof Nanomaterials in Drug Intoxication Treatment","volume":"6","author":"Graham","year":"2011","journal-title":"Nanomedicine (London, U. K.)"},{"key":"2026090217383956800_cit4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1136\/emj.2006.034603","article-title":"Medico-legal Consideration of Gastric Lavage in Acutely Intoxicated\nPatients","volume":"24","author":"Bae","year":"2007","journal-title":"Emerg. Med. J."},{"key":"2026090217383956800_cit5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/0736-4679(86)90219-2","article-title":"Gastrointestinal Obstruction Associated\nWith Multiple-Dose Activated Charcoal","volume":"4","author":"Watson","year":"1986","journal-title":"J. Emerg.\nMed."},{"key":"2026090217383956800_cit6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/BF03259930","article-title":"Oral Activated Charcoal in the Treatment of Intoxications","volume":"3","author":"Neuvonen","year":"1988","journal-title":"Med. Toxicol. Adverse Drug Exp."},{"key":"2026090217383956800_cit7","first-page":"312","article-title":"Poisonings","volume-title":"Pediatric Emergency Medicine\nSecrets","author":"Wiley","year":"2015"},{"key":"2026090217383956800_cit8","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1002\/jps.2600810916","article-title":"Reversible Adsorption\nof Nicotinic Acid onto Charcoal\nIn","volume":"81","author":"Roivas","year":"1992","journal-title":"J. Pharm. Sci."},{"key":"2026090217383956800_cit9","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nnano.2007.339","article-title":"Injectable\nNanocarriers for Biodetoxification","volume":"2","author":"Leroux","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"2026090217383956800_cit10","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.3390\/ma3042483","article-title":"Current and Emerging\nDetoxification Therapies for Critical\nCare","volume":"3","author":"Howell","year":"2010","journal-title":"Materials"},{"key":"2026090217383956800_cit11","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/1521-3773(20020118)41:2&lt;265::AID-ANIE265&gt;3.0.CO;2-Q","article-title":"A Novel\nConcept of Reversing Neuromuscular\nBlock: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based\nSynthetic Host","volume":"41","author":"Bom","year":"2002","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090217383956800_cit12","doi-asserted-by":"publisher","first-page":"22484","DOI":"10.1039\/C5TA05440K","article-title":"Towards the Use of\nMetal-Organic Frameworks for Water Reuse: A Review\nof the Recent Advances in the Field of Organic Pollutants Removal\nand Degradation and the next Steps in the Field","volume":"3","author":"Dias","year":"2015","journal-title":"J. Mater. Chem. A"},{"issue":"19","key":"2026090217383956800_cit13","doi-asserted-by":"publisher","first-page":"6204","DOI":"10.1021\/jacs.6b01663","article-title":"Highly Stable Zr(IV)-Based\nMetal-Organic Frameworks for the Detection and Removal of Antibiotics\nand Organic Explosives in Water","volume":"138","author":"Wang","year":"2016","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090217383956800_cit14","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1021\/es505014z","article-title":"Spatial Confinement\nof a Co3O4 Catalyst in Hollow Metal\u2013Organic Frameworks as a\nNanoreactor for Improved Degradation of Organic Pollutants","volume":"49","author":"Zeng","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"2026090217383956800_cit15","doi-asserted-by":"publisher","first-page":"12004","DOI":"10.1002\/chem.201403501","article-title":"An Exceptionally Stable and Water-Resistant Metal-Organic\nFramework with Hydrophobic Nanospaces for Extracting Aromatic Pollutants\nfrom Water","volume":"20","author":"Wang","year":"2014","journal-title":"Chem. - Eur. J."},{"key":"2026090217383956800_cit16","doi-asserted-by":"publisher","first-page":"14455","DOI":"10.1039\/C4CC06648K","article-title":"A Porous Metal\u2013organic Framework\nwith \u2013 COOH Groups for Highly Efficient Pollutant Removal","volume":"50","author":"Zhang","year":"2014","journal-title":"Chem. Commun."},{"key":"2026090217383956800_cit17","doi-asserted-by":"publisher","first-page":"8231","DOI":"10.1039\/c2cc33707j","article-title":"Fast Capture\nand Separation of, and Luminescent Probe for, Pollutant Chromate Using\na Multi-Functional Cationic Heterometal-Organic Framework","volume":"48","author":"Shi","year":"2012","journal-title":"Chem. Commun."},{"key":"2026090217383956800_cit18","doi-asserted-by":"publisher","first-page":"15565","DOI":"10.1002\/anie.201707346","article-title":"A Smart Metal-Organic\n-Framework Nanomaterials for Lung Targeting","volume":"56","author":"Simon-Yarza","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"issue":"2","key":"2026090217383956800_cit19","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.ijpharm.2016.08.010","article-title":"Vivo Behavior of MIL-100 Nanoparticles at Early Times\nafter Intravenous Administration","volume":"511","author":"Simon-Yarza","year":"2016","journal-title":"Int. J. Pharm."},{"key":"2026090217383956800_cit20","doi-asserted-by":"publisher","first-page":"1606134","DOI":"10.1002\/adma.201606134","article-title":"Metal\u2013Organic\nFramework (MOF)-Based Drug\/Cargo\nDelivery and Cancer Therapy","volume":"29","author":"Wu","year":"2017","journal-title":"Adv. Mater."},{"key":"2026090217383956800_cit21","doi-asserted-by":"publisher","first-page":"43099","DOI":"10.1038\/srep43099","article-title":"Chitosan-Coated\nMesoporous MIL-100(Fe) Nanoparticles as Improved Bio-Compatible Oral\nNanocarriers","volume":"7","author":"Hidalgo","year":"2017","journal-title":"Sci. Rep."},{"key":"2026090217383956800_cit22","doi-asserted-by":"publisher","first-page":"6486","DOI":"10.1039\/c3cc40449h","article-title":"MOF@activated\nCarbon: A New Material for Adsorption of Aldicarb in Biological Systems","volume":"49","author":"de Oliveira","year":"2013","journal-title":"Chem. Commun."},{"key":"2026090217383956800_cit23","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1039\/C2CY00376G","article-title":"Iron(III) Metal\u2013organic\nFrameworks as Solid Lewis Acids for the Isomerization of \u03b1-Pinene\nOxide","volume":"2","author":"Dhakshinamoorthy","year":"2012","journal-title":"Catal. Sci. Technol."},{"key":"2026090217383956800_cit24","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1002\/anie.200604306","article-title":"Assembly of\nMetal-Organic Frameworks\n(MOFs) Based on Indium-Trimer Building Blocks: A Porous MOF with Soc\nTopology and High Hydrogen Storage","volume":"46","author":"Liu","year":"2007","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026090217383956800_cit25","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1039\/C3TB20832J","article-title":"Cytotoxicity of Nanoscaled Metal\u2013organic\nFrameworks","volume":"2","author":"Tamames-Tabar","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"2026090217383956800_cit26","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1039\/C5CE01864A","article-title":"Synthesis of the Biocompatible and\nHighly Stable MIL-127(Fe): From Large Scale Synthesis to Particle\nSize Control","volume":"18","author":"Chevreau","year":"2016","journal-title":"CrystEngComm"},{"key":"2026090217383956800_cit27","first-page":"286","article-title":"Toxicity\nof Nanomaterials on\nthe Liver, Kidney, and Spleen","volume-title":"Biointeractions\nof Nanomaterials","author":"Patel","year":"2015"},{"key":"2026090217383956800_cit28","unstructured":"Substances\nmost frequently involved in pediatric poisoning deaths in the U.S.\nin 2016. https:\/\/www.statista.com\/statistics\/654778\/pediatric-poisoning-deaths-major-substances-united-states\/ (accessed May 5, 2018)."},{"key":"2026090217383956800_cit29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12995-016-0118-5","article-title":"Acetylsalicylic\nAcid as a Potential Pediatric Health Hazard: Legislative Aspects Concerning\nAccidental Intoxications in the European Union","volume":"11","author":"Mund","year":"2016","journal-title":"J. Occup. Med. Toxicol."},{"key":"2026090217383956800_cit30","volume-title":"Biomembranes","author":"Smyth","year":"1974","edition":"1"},{"key":"2026090217383956800_cit31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.fct.2004.08.007","article-title":"Applicability\nof an in Vitro Digestion\nModel in Assessing the Bioaccessibility of Mycotoxins from Food","volume":"43","author":"Versantvoort","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"2026090217383956800_cit32","doi-asserted-by":"publisher","first-page":"13850","DOI":"10.1021\/ja8057953","article-title":"A New Zirconium\nInorganic Building\nBrick Forming Metal Organic Frameworks with Exceptional Stability","volume":"130","author":"Cavka","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"2026090217383956800_cit33","doi-asserted-by":"publisher","first-page":"6632","DOI":"10.1021\/cm102601v","article-title":"Synthesis and Stability of Tagged\nUiO-66 Zr-MOFs","volume":"22","author":"Kandiah","year":"2010","journal-title":"Chem. Mater."},{"key":"2026090217383956800_cit34","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0041-008X(59)90107-3","article-title":"The Acute\nOral Toxicity of Acetylsalicylic Acid","volume":"1","author":"Boyd","year":"1959","journal-title":"Toxicol.\nAppl. Pharmacol."},{"key":"2026090217383956800_cit35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A Simple Practice Guide for Dose\nConversion between Animals and Human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic\nClin. Pharm."},{"key":"2026090217383956800_cit36","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(68)92204-6","article-title":"Aspirin Adsorption\nwith Activated Charcoal","volume":"291","author":"Decker","year":"1968","journal-title":"Lancet"},{"issue":"12","key":"2026090217383956800_cit37","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1124\/dmd.31.12.1507","article-title":"Modeling\nof Intestinal Drug Absorption: Roles of Transporters and Metabolic\nEnzymes (for the Gillette Review Series)","volume":"31","author":"Pang","year":"2003","journal-title":"Drug\nMetab. Dispos."},{"key":"2026090217383956800_cit38","first-page":"11","article-title":"Protective\nEffects of Ginger against\nAspirin-Induced Gastric Ulcers in Rats","volume":"54","author":"Wang","year":"2011","journal-title":"Yonago\nActa Med."},{"key":"2026090217383956800_cit39","doi-asserted-by":"publisher","first-page":"48","DOI":"10.14309\/crj.2014.81","article-title":"Aspirin-Induced Acute\nLiver Injury","volume":"2","author":"Laster","year":"2014","journal-title":"ACG Case Rep. J."},{"key":"2026090217383956800_cit40","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1001\/archinte.1981.00340030065013","article-title":"Effects\nof Aspirin and Acetaminophen on the Liver","volume":"141","author":"Zimmerman","year":"1981","journal-title":"Arch.\nIntern. Med."},{"issue":"March","key":"2026090217383956800_cit41","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3109\/17435390.2013.782076","article-title":"Solid Lipid Nanoparticles Induced\nHematological Changes and Inflammatory Response in Mice","volume":"8","author":"Silva","year":"2014","journal-title":"Nanotoxicology"},{"key":"2026090217383956800_cit42","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1039\/c3sc22116d","article-title":"In Depth Analysis\nof the in Vivo\nToxicity of Nanoparticles of Porous Iron(III) Metal-Organic Frameworks","volume":"4","author":"Baati","year":"2013","journal-title":"Chem. Sci."},{"key":"2026090217383956800_cit43","first-page":"285","article-title":"Protective Effect of Gum Acacia against\nthe Aspirin Induced Intestinal and Pancreatic Alterations","volume":"15","author":"Nasif","year":"2011","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"2026090217383956800_cit44","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/15216540500149904","article-title":"Systemic Regulation of Intestinal\nIron Absorption","volume":"57","author":"Steele","year":"2005","journal-title":"IUBMB Life"},{"key":"2026090217383956800_cit45","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1208\/s12249-009-9207-4","article-title":"Permeation of\nFour Oral Drugs through Human Intestinal\nMucosa","volume":"10","author":"Pretorius","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"2026090217383956800_cit46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4103\/0253-7613.77351","article-title":"Influence of Drug\nConcentration on the Diffusion Parameters of Caffeine","volume":"43","author":"Mustapha","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"2026090217383956800_cit47","doi-asserted-by":"publisher","first-page":"8569","DOI":"10.1016\/j.biomaterials.2012.07.063","article-title":"Size-Dependent Absorption Mechanism\nof Polymeric Nanoparticles for Oral Delivery of Protein Drugs","volume":"33","author":"He","year":"2012","journal-title":"Biomaterials"},{"key":"2026090217383956800_cit48","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/2050-6511-14-34","article-title":"Quantitation\nof Small Intestinal Permeability during Normal Human Drug Absorption","volume":"14","author":"Levitt","year":"2013","journal-title":"BMC Pharmacol. Toxicol."},{"key":"2026090217383956800_cit49","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/2211068214561025","article-title":"TEER Measurement Techniques for In Vitro Barrier Model\nSystems","volume":"20","author":"Srinivasan","year":"2015","journal-title":"J. Lab. Autom."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.8b04435","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/140\/30\/9581\/67021793\/jacs.8b04435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/140\/30\/9581\/67021793\/jacs.8b04435.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:38:45Z","timestamp":1788385125000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/140\/30\/9581\/688767\/Metal-Organic-Frameworks-as-Efficient-Oral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":49,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2018,7,10]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.8b04435","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,10]]}}}