{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:26:22Z","timestamp":1789986382646,"version":"4.0.1"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFA0208700"],"award-info":[{"award-number":["2018YFA0208700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFA0303500"],"award-info":[{"award-number":["2017YFA0303500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["WK2340000064"],"award-info":[{"award-number":["WK2340000064"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21473177"],"award-info":[{"award-number":["21473177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21790350"],"award-info":[{"award-number":["21790350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21633007"],"award-info":[{"award-number":["21633007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2016HSC-IU003"],"award-info":[{"award-number":["2016HSC-IU003"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anhui Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2019,2,6]]},"DOI":"10.1021\/jacs.8b08537","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T02:44:27Z","timestamp":1547001867000},"page":"1941-1948","source":"Crossref","is-referenced-by-count":91,"title":["Misfolding of a Human Islet Amyloid Polypeptide at the Lipid Membrane Populates through \u03b2-Sheet Conformers without Involving \u03b1-Helical Intermediates"],"prefix":"10.1021","volume":"141","author":[{"given":"Junjun","family":"Tan","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics, and Synergetic Innovation Center of Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics, and Synergetic Innovation Center of Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics, and Synergetic Innovation Center of Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-5258","authenticated-orcid":true,"given":"Shuji","family":"Ye","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics, and Synergetic Innovation Center of Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079469"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/ja204035k"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/ja403147m"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/ja1081537"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ja903814q"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314481110"},{"key":"ref8\/cit8","first-page":"6033","volume-title":"Proc. Natl. Acad. Sci. U.S.A.","volume":"105","author":"Engel M. F. M.","year":"2008"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805957106"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0037"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ja900285z"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906670"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507092"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.06.012"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/bi060579z"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801383200"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja201575e"},{"key":"ref18\/cit18","first-page":"7293063","author":"Fu L.","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.5b00326"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.035"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06000"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.050708.133622"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/ja103438w"},{"key":"ref24\/cit24","volume-title":"The Principles of Nonlinear Optics","author":"Shen Y. R.","year":"1984"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1081\/ASR-200038326"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/la203823t"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/cr4006044"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00091"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ja3031664"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja411081t"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06720"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1116\/1.4982710"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1116\/1.3317116"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.10.017"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jp075950m"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b01937"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ja054721f"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583502003815"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60528-8"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ja3119527"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jz201540r"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ja074188z"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ja021464v"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.812388"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.5149"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b00522"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.08.058"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.07.009"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1063\/1674-0068\/30\/cjcp1706114"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706996"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/c1an15032d"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09510"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201500562"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360250307"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(81)84749-2"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1985.tb03192.x"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.2.774"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.04.012"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/jz500794d"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/ja909546b"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0752298.x"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2433563100"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ja905595k"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.12.018"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/ja100431q"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/bi0100283"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/bi0348157"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/bi051672a"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC01533C"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b08865"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.6b05677"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.7b03092"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphys.2013.02.016"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.02.010"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/ja9010095"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408135102"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009362108"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.04.012"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/jz5001775"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305517110"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1116\/1.4971381"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.8b08537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T22:23:08Z","timestamp":1681597388000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.8b08537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,2,6]]}},"alternative-id":["10.1021\/jacs.8b08537"],"URL":"https:\/\/doi.org\/10.1021\/jacs.8b08537","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]}}}