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SATOs decompose in the presence of cysteine to generate hydrogen sulfide (H2S), a biological signaling gas with therapeutic potential. The PHDCs self-assemble in aqueous solution into different morphologies, two into nanoribbons of different dimensions and one into a rigid nanocoil. The rate of H2S release from the PHDCs depends on the morphology, with the nanocoil-forming PHDC exhibiting a complex release profile driven by morphological changes promoted by SATO decomposition. The nanocoil-forming PHDC mitigated the cardiotoxicity of doxorubicin more effectively than its nanoribbon-forming constitutional isomers as well as common H2S donors. This strategy opens up new avenues to develop H2S-releasing biomaterials and highlights the interplay between structure and function from the molecular level to the nanoscale.<\/jats:p>","DOI":"10.1021\/jacs.8b09320","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T08:01:38Z","timestamp":1540627298000},"page":"14945-14951","source":"Crossref","is-referenced-by-count":82,"title":["Self-Assembled\nNanostructures Regulate H2S Release from Constitutionally\nIsomeric Peptides"],"prefix":"10.1021","volume":"140","author":[{"given":"Yin","family":"Wang","sequence":"first","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuljeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Scannelli","sequence":"additional","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Bitton","sequence":"additional","affiliation":[{"name":"Ben-Gurion University of the Negev , , ,","place":["Beer-Sheva, Israel, 84105"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-5396","authenticated-orcid":true,"given":"John B.","family":"Matson","sequence":"additional","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,10,27]]},"reference":[{"key":"2026090123275517400_cit1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1432-1033.1990.tb19116.x","article-title":"Identification and role of the basal phosphorylation\nsite on hormone-sensitive lipase","volume":"191","author":"Garton","year":"1990","journal-title":"Eur. 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