{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:50:38Z","timestamp":1793915438195,"version":"4.8.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3503903"],"award-info":[{"award-number":["2023YFC3503903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZB20230462"],"award-info":[{"award-number":["GZB20230462"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACS Au"],"published-print":{"date-parts":[[2025,9,22]]},"DOI":"10.1021\/jacsau.5c00817","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:53:21Z","timestamp":1756306401000},"page":"4472-4480","source":"Crossref","is-referenced-by-count":14,"title":["Directed Evolution of Nonheme Iron Enzymes for Enantioselective Aminative Difunctionalization of Alkenes"],"prefix":"10.1021","volume":"5","author":[{"given":"Fei","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Shan","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hua","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-1879","authenticated-orcid":true,"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7249-8180","authenticated-orcid":true,"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5143-4875","authenticated-orcid":true,"given":"Zhi-Jun","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Biopharmaceutics, West China School of Pharmacy","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children\u2019s Medicine Key Laboratory of Sichuan Province, Department of Pharmacy\/Evidence-Based Pharmacy Center, West China Second University Hospital","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/cr100371y"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00328"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201800053"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00681H"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.05.013"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00529"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO00081D"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC03552F"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202402458"},{"key":"ref10\/cit10","volume-title":"Amino Group Chemistry: From Synthesis to the Life Sciences","author":"Wiley-VCH","year":"2008"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/cs400138b"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1719822"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB02446E"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1039\/D1QO00375E"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00831"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12663"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00307"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ja508057u"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b07221"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507630"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat3863"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11025"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202017175"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11083"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0385-5"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00044-z"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh8615"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07506-w"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00689A"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC07828A"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c03173"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c14310"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423507"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1438"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00944-x"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj2830"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00507-7"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00536-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-024-01257-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202506361"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201812968"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/b702158e"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nature04544"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.2c00115"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11608"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/bi0484421"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010647"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201402498"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/bi049317s"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201103077"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2005.09.028"}],"container-title":["JACS Au"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.5c00817","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.5c00817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T08:12:10Z","timestamp":1758528730000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.5c00817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,22]]}},"alternative-id":["10.1021\/jacsau.5c00817"],"URL":"https:\/\/doi.org\/10.1021\/jacsau.5c00817","relation":{},"ISSN":["2691-3704","2691-3704"],"issn-type":[{"value":"2691-3704","type":"print"},{"value":"2691-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}