{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:41:24Z","timestamp":1791848484507,"version":"4.3.4"},"reference-count":84,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI169595"],"award-info":[{"award-number":["R01 AI169595"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACS Au"],"published-print":{"date-parts":[[2025,12,22]]},"DOI":"10.1021\/jacsau.5c01046","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:25:40Z","timestamp":1763119540000},"page":"6085-6099","source":"Crossref","is-referenced-by-count":2,"title":["Protonated Phenanthroline Catalyzed Stereoselective Glycosylation: Synthesis and Evaluation of Saponin Adjuvant Lablaboside F and Variants Leading to Simplified Vaccine Adjuvants"],"prefix":"10.1021","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-3575","authenticated-orcid":true,"given":"Jayanta","family":"Ghorai","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Detroit, United States"]},{"name":"Wayne State University","place":["Detroit, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin B.","family":"Santhin","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Memphis, United States"]},{"name":"St. Jude Children\u2019s Research Hospital","place":["Memphis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-8299","authenticated-orcid":true,"given":"Leila","family":"Almounajed","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Detroit, United States"]},{"name":"Wayne State University","place":["Detroit, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey M.","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases","place":["Memphis, United States"]},{"name":"St. Jude Children\u2019s Research Hospital","place":["Memphis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Varga","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Memphis, United States"]},{"name":"St. Jude Children\u2019s Research Hospital","place":["Memphis, United States"]},{"name":"Department of Infectious Diseases","place":["Memphis, United States"]},{"name":"St. Jude Children\u2019s Research Hospital","place":["Memphis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-8439","authenticated-orcid":true,"given":"Hien M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Detroit, United States"]},{"name":"Wayne State University","place":["Detroit, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2015.15.2.51"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1210"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1780847"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.07.021"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1939620"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21523"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033457340"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(03)02864-2"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/1044-579X(95)90007-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01248"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01557-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9030222"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1105655"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1080\/10408390600698197"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS241310505"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2014.953628"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25214974"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4899-1367-8_1","volume-title":"Saponins Used in Traditional and Modern Medicine","volume":"404","author":"Balandrin M. F.","year":"1996"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47040250"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00025"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.091"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/pathophysiology28020017"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2000.009"},{"key":"ref24\/cit24","volume-title":"The Leguminosae, a Source Book of Characteristics, Uses, and Nodulation","author":"Allen O. N.","year":"1981"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.46.812"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3987\/COM-97-8095"},{"key":"ref27\/cit27","first-page":"1120","volume-title":"Pharmacognosie, Phytochimie","author":"Bruneton J.","year":"1995"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-020-00244-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ja801008m"},{"key":"ref30\/cit30","volume-title":"Frontiers in Immunology","author":"Singleton K. L.","year":"2023"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15107235"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c10633"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198602121"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b02066"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja015991a"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/C004281A"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jo702436p"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02563"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ja801008m"},{"key":"ref40\/cit40","series-title":"Best Synthetic Methods","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/B978-012312085-4\/50009-X","volume-title":"Carbohydrates","author":"Pietruszka J.","year":"2003"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)00142-7"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00215"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-020-0329-7"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/ja0422007"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.003"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.08.002"},{"key":"ref47\/cit47","unstructured":"THP1-Dual|NF-\u03baB & IFN Reporter\nTHP1 monocyte| InvivoGen. https:\/\/www.invivogen.com\/thp1-dual (accessed July 22, 2025)."},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1101\/PDB.PROT095497"},{"key":"ref49\/cit49","first-page":"48","volume":"11","author":"Fields R. D.","year":"1993","journal-title":"Am. Biotechnol. Lab."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90396-4"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01606.x"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(01)00014-5"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90438-6"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12973"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-016-9998-6"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029695"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00046-9"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402195"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.908529"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.139"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.683011"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152905"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.11.062"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/NU14030623"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2024.100845"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.12.036"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9030222"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3390\/VACCINES7040124"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03164.x"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747208"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737314"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.02.010"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00775.x"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1086\/417049"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/nature11047"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323185"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141103"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00008-8"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(97)00288-0"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.6.4931-4939.1998"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2283"}],"container-title":["JACS Au"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.5c01046","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.5c01046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:03:44Z","timestamp":1768561424000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.5c01046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":84,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,22]]}},"alternative-id":["10.1021\/jacsau.5c01046"],"URL":"https:\/\/doi.org\/10.1021\/jacsau.5c01046","relation":{},"ISSN":["2691-3704","2691-3704"],"issn-type":[{"value":"2691-3704","type":"print"},{"value":"2691-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}