{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:47Z","timestamp":1792784807667,"version":"4.5.0"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1201200"],"award-info":[{"award-number":["2021YFA1201200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF1200404"],"award-info":[{"award-number":["2021YFF1200404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25B020003"],"award-info":[{"award-number":["LMS25B020003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Artificial Intelligence Lab","award":["P22KN00272"],"award-info":[{"award-number":["P22KN00272"]}]},{"name":"Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study","award":["SN-ZJU-SIAS-003"],"award-info":[{"award-number":["SN-ZJU-SIAS-003"]}]},{"name":"National Center of Technology Innovation for Biopharmaceuticals","award":["NCTIB2022HS02010"],"award-info":[{"award-number":["NCTIB2022HS02010"]}]},{"name":"National Independent Innovation Demonstration Zone Shanghai Zhangjiang Major Projects","award":["ZJZX2020014"],"award-info":[{"award-number":["ZJZX2020014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACS Au"],"published-print":{"date-parts":[[2026,1,26]]},"DOI":"10.1021\/jacsau.5c01216","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:10:32Z","timestamp":1767985832000},"page":"279-289","source":"Crossref","is-referenced-by-count":4,"title":["PSMA-Targeting Chimeras for Cell-Type-Specific Degradation of Surface Immune Checkpoint Protein PD-L1"],"prefix":"10.1021","volume":"6","author":[{"given":"Yuqing","family":"Luo","sequence":"first","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"},{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 3 Taicheng Road, Yangling, 712100, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Gong","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, School of Pharmaceutical Sciences","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Peng","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, School of Pharmaceutical Sciences","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3252-9756","authenticated-orcid":true,"given":"Yanqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Cell and Molecular Intelligent Design and Development, Institute of Quantitative Biology, College of Life Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Gao","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 3 Taicheng Road, Yangling, 712100, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery","place":["Nantong, China"]},{"name":"Affiliated Hospital of Nantong University","place":["Nantong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-9214","authenticated-orcid":true,"given":"Jinxin","family":"Che","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"},{"name":"National Key Laboratory of Advanced Drug Delivery and Release Systems","place":["Hangzhou, China"]},{"name":"Zhejiang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-4372","authenticated-orcid":true,"given":"Xiaowu","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"},{"name":"National Key Laboratory of Advanced Drug Delivery and Release Systems","place":["Hangzhou, China"]},{"name":"Zhejiang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2598-3456","authenticated-orcid":true,"given":"Jiang-Jiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 3 Taicheng Road, Yangling, 712100, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-2453","authenticated-orcid":true,"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, School of Pharmaceutical Sciences","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7412-9646","authenticated-orcid":true,"given":"Peng","family":"Teng","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China"},{"name":"National Key Laboratory of Advanced Drug Delivery and Release Systems","place":["Hangzhou, China"]},{"name":"Zhejiang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-5591","authenticated-orcid":true,"given":"Ruhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Cell and Molecular Intelligent Design and Development, Institute of Quantitative Biology, College of Life Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang University","place":["Hangzhou, China"]},{"name":"Shanghai Institute for Advanced Study","place":["Shanghai, China"]},{"name":"Zhejiang University","place":["Shanghai, China"]},{"name":"Cancer Center","place":["Hangzhou, China"]},{"name":"Zhejiang University","place":["Hangzhou, China"]},{"name":"Department of Chemistry","place":["New York, United States"]},{"name":"Columbia University","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00652-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.020"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05235-6"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.2c00587"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.031"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1722-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00833-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10008"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102170"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf6249"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01456-2"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.1003.1036"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00624C"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2545-9"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02463"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08367"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC02361C"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.01.002"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52685-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07947-3"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00584"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300694"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00770-1"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00851-1"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00146"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46130-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.02.037"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1223"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00394-5"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-024-00900-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01910"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05388-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.04.029"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94603-9"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf4412"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00293"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147431"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ct300400x"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01053"}],"container-title":["JACS Au"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.5c01216","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.5c01216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T09:13:30Z","timestamp":1769418810000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.5c01216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,26]]}},"alternative-id":["10.1021\/jacsau.5c01216"],"URL":"https:\/\/doi.org\/10.1021\/jacsau.5c01216","relation":{},"ISSN":["2691-3704","2691-3704"],"issn-type":[{"value":"2691-3704","type":"print"},{"value":"2691-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]}}}