{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:10:09Z","timestamp":1791846609781,"version":"4.3.4"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750237"],"award-info":[{"award-number":["2024M750237"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["2264097"],"award-info":[{"award-number":["2264097"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22507149"],"award-info":[{"award-number":["22507149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577159"],"award-info":[{"award-number":["22577159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92578127"],"award-info":[{"award-number":["92578127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-1-026"],"award-info":[{"award-number":["2021-I2M-1-026"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2025-I2M-KJ-014"],"award-info":[{"award-number":["2025-I2M-KJ-014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACS Au"],"published-print":{"date-parts":[[2026,3,23]]},"DOI":"10.1021\/jacsau.6c00079","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:00:36Z","timestamp":1772661636000},"page":"1977-1987","source":"Crossref","is-referenced-by-count":2,"title":["Deciphering How Clustered O-Glycosylation Shapes Substrate-Binding Preferences in an Intrinsically Disordered Protein Region"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-4673","authenticated-orcid":true,"given":"Ruihan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]},{"name":"Chemical Engineering College","place":["Qinhuangdao, China"]},{"name":"Hebei Normal University of Science & Technology","place":["Qinhuangdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiekang","family":"Tian","sequence":"additional","affiliation":[{"name":"Center of Pharmaceutical Technology, School of Pharmaceutical Sciences","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerun","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-9042","authenticated-orcid":true,"given":"Yaohao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-8296","authenticated-orcid":true,"given":"Dingguo","family":"Xu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Shang","sequence":"additional","affiliation":[{"name":"Center of Pharmaceutical Technology, School of Pharmaceutical Sciences","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400525m"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00158"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214050"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6807-11-29"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1226"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/bi012159+"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/pr060394e"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11124991"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2022.106769"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00673-0"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC05016J"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58692-8"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nature13999"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901898RR"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.engmic.2021.100005"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/bbb.4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/463074"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2560119.x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70080"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2011.11.030"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2022.2144117"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1186\/1754-6834-1-10"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309106110"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25889"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/bs.accb.2015.08.001"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135334"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202100543"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11543"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202518002"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadva.2024.100134"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1590834"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402518111"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01812K"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.10.032"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b01055"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02636A"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ja808704m"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2361"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.270389"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202300035"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/cr500351c"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s12155-018-9944-x"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00676"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/bip.10587"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201903132"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23242"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03757"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx8201"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00138-0"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/bi00444a016"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/jp203695t"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/ct200328p"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/C8GC03209B"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"}],"container-title":["JACS Au"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.6c00079","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.6c00079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:12:34Z","timestamp":1774253554000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.6c00079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,23]]}},"alternative-id":["10.1021\/jacsau.6c00079"],"URL":"https:\/\/doi.org\/10.1021\/jacsau.6c00079","relation":{},"ISSN":["2691-3704","2691-3704"],"issn-type":[{"value":"2691-3704","type":"print"},{"value":"2691-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]}}}