{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:11:34Z","timestamp":1787001094731,"version":"build-2736575974"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACS Au"],"published-print":{"date-parts":[[2026,5,25]]},"DOI":"10.1021\/jacsau.6c00256","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:33:29Z","timestamp":1777458809000},"page":"2924-2934","source":"Crossref","is-referenced-by-count":1,"title":["Aggregicyclins Shed Light on Type II Polyketide Biosynthesis in\n                    <i>Myxococcota<\/i>"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-7956","authenticated-orcid":true,"given":"Chantal D.","family":"Bader","sequence":"first","affiliation":[{"name":"Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbr\u00fccken66123, Germany"},{"name":"PharmaScienceHub","place":["Saarbr\u00fccken, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Panter","sequence":"additional","affiliation":[{"name":"Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbr\u00fccken66123, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Panter","sequence":"additional","affiliation":[{"name":"Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbr\u00fccken66123, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amay Ajaykumar","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Research Group Drug Bioinformatics, Helmholtz Centre for Infection Research (HZI)","place":["Saarbr\u00fccken, Germany"]},{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)","place":["Saarbr\u00fccken, Germany"]},{"name":"Center for Bioinformatics","place":["Saarbr\u00fccken, Germany"]},{"name":"Saarland University","place":["Saarbr\u00fccken, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9445-477X","authenticated-orcid":true,"given":"Olga V.","family":"Kalinina","sequence":"additional","affiliation":[{"name":"Research Group Drug Bioinformatics, Helmholtz Centre for Infection Research (HZI)","place":["Saarbr\u00fccken, Germany"]},{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)","place":["Saarbr\u00fccken, Germany"]},{"name":"PharmaScienceHub","place":["Saarbr\u00fccken, Germany"]},{"name":"Center for Bioinformatics","place":["Saarbr\u00fccken, Germany"]},{"name":"Saarland University","place":["Saarbr\u00fccken, Germany"]},{"name":"Medical Faculty","place":["Homburg, Germany"]},{"name":"Saarland University","place":["Homburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-5665","authenticated-orcid":true,"given":"Rolf","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbr\u00fccken66123, Germany"},{"name":"PharmaScienceHub","place":["Saarbr\u00fccken, Germany"]},{"name":"German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig","place":["Braunschweig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5c01368"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110749"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14121183"},{"key":"ref5\/cit5","unstructured":"GMInsights.\n                      Doxorubicin Market\n\u2013 By Drug\nFormulation (Lyophilized Powder, Doxorubicin Injection), Application\n(Breast, Liver, Kidney, Sarcoma, Ovarian, Lung, Leukemia), Distribution\nChannel (Hospital, Retail, Online Pharmacy)- Global Forecast, 2024\n\u2013 2032\n                      . https:\/\/www.gminsights.com\/industry-analysis\/doxorubicin-market (accessed 2026\u201301\u201308)."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06354.x"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.1.305-318.1999"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/synbio2010006"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/b103920m"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000965"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01325J"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/C1MB05328K"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.061176-0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad344"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad984"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.64898\/2026.02.12.705523"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0400-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt282"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2023.168018"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c00942"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1115"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1318"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21450"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1249"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01110-12"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02725E"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-018-2105-6"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/2417"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm818"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.1309"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01771"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0800300321"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-018-02131-9"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709223105"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja069045b"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1999.tb13398.x"}],"container-title":["JACS Au"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.6c00256","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.6c00256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:11:38Z","timestamp":1779696698000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.6c00256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,25]]}},"alternative-id":["10.1021\/jacsau.6c00256"],"URL":"https:\/\/doi.org\/10.1021\/jacsau.6c00256","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.15000217\/v1","asserted-by":"object"}]},"ISSN":["2691-3704","2691-3704"],"issn-type":[{"value":"2691-3704","type":"print"},{"value":"2691-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}