{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:45:13Z","timestamp":1788403513564,"version":"build-2803163510"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["JYB2025XDXM609"],"award-info":[{"award-number":["JYB2025XDXM609"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2022-RC350-02"],"award-info":[{"award-number":["2022-RC350-02"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404404"],"award-info":[{"award-number":["82404404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cyclization of linear peptides into macrocyclic structures confers superior properties such as improved membrane permeability and proteolytic stability while maintaining high target affinity and specificity toward protein targets. Here, we present a cysteine-selective macrocyclization strategy that employs an alkylating motif of chloroethyl tetrazine to react with the thiol side chain in unprotected peptides. This approach efficiently yields cyclic peptides bearing bioorthogonal tetrazine handles, enabling precise late-stage modification via robust tetrazine ligations. We applied this method to synthesize and screen rofapitide tetraxetan analogues, identifying a novel peptide 2o, which exhibits potent binding to cancer-associated fibroblast activation protein (FAP) both in vitro and in vivo. Furthermore, we developed an innovative bioorthogonal cell penetration assay (BCPA) based on a \u201cclick-to-release\u201d reaction between the tetrazine-containing peptide (Tz-Pep) and a trans-cyclooctene-caged Nile Blue dye (TCO-Nile Blue) to liberate fluorescent Nile Blue, allowing quantitative evaluation of peptide internalization in living cells. We anticipate that this tetrazine-mediated cyclization strategy and cell penetration assay will find wide applications in biological research and drug discovery.<\/jats:p>","DOI":"10.1021\/jacsau.6c00457","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:49:08Z","timestamp":1781678948000},"page":"3903-3913","source":"Crossref","is-referenced-by-count":1,"title":["Tetrazine-Enabled\nPeptide Macrocyclization and Bioorthogonal\nCell Penetration Profiling"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-1299","authenticated-orcid":true,"given":"Hao","family":"Liu","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenyang Pharmaceutical University , , ,","place":["Shenyang, P. R. China, 110016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenyang Pharmaceutical University , , ,","place":["Shenyang, P. R. China, 110016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieting","family":"Shen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Ma","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Kong","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-2742","authenticated-orcid":true,"given":"Xian","family":"Jia","sequence":"additional","affiliation":[{"name":"Shenyang Pharmaceutical University , , ,","place":["Shenyang, P. R. China, 110016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2549-629X","authenticated-orcid":true,"given":"Kuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]},{"name":"Lanzhou University , , ,","place":["Lanzhou, P. R. China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-9275","authenticated-orcid":true,"given":"Luping","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, P. R. China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"issue":"4","key":"2026072709074035400_cit1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","article-title":"Trends in Peptide\nDrug Discovery","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"15","key":"2026072709074035400_cit2","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1021\/acs.chemrev.4c00989","article-title":"Advances in Peptidomimetics\nfor Next-Generation Therapeutics: Strategies, Modifications, and Applications","volume":"125","author":"Lombardi","year":"2025","journal-title":"Chem. Rev."},{"key":"2026072709074035400_cit3","doi-asserted-by":"publisher","first-page":"101208","DOI":"10.1016\/j.drup.2025.101208","article-title":"Rational Design of\nPeptides to Overcome Drug Resistance by Metabolic Regulation","volume":"79","author":"Sun","year":"2025","journal-title":"Drug Resist. Updates"},{"issue":"24","key":"2026072709074035400_cit4","doi-asserted-by":"publisher","first-page":"12375","DOI":"10.1021\/acs.chemrev.9b00402","article-title":"Cyclotides: From\nStructure to Function","volume":"119","author":"De Veer","year":"2019","journal-title":"Chem. Rev."},{"issue":"27","key":"2026072709074035400_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300647","article-title":"Peptide Cyclization by the Use of Acylammonium Species","volume":"62","author":"Shamoto","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"issue":"48","key":"2026072709074035400_cit6","doi-asserted-by":"publisher","first-page":"15094","DOI":"10.1021\/jacs.5b10779","article-title":"Orthogonal Cysteine-Penicillamine\nDisulfide Pairing for Directing the Oxidative Folding of Peptides","volume":"137","author":"Zheng","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"2026072709074035400_cit7","doi-asserted-by":"publisher","first-page":"11725","DOI":"10.1039\/D3CS01066J","article-title":"Recent\nAdvances in Peptide Macrocyclization Strategies","volume":"53","author":"Fang","year":"2024","journal-title":"Chem. Soc. Rev."},{"issue":"7","key":"2026072709074035400_cit8","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1039\/D3SC05738K","article-title":"Biocompatible\nStrategies for Peptide\nMacrocyclisation","volume":"15","author":"He","year":"2024","journal-title":"Chem. Sci."},{"issue":"7","key":"2026072709074035400_cit9","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nchembio.184","article-title":"Phage-Encoded Combinatorial\nChemical Libraries Based on Bicyclic Peptides","volume":"5","author":"Heinis","year":"2009","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"2026072709074035400_cit10","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1021\/acschembio.5b00963","article-title":"Phage Selection of\nChemically Stabilized \u03b1-Helical Peptide Ligands","volume":"11","author":"Diderich","year":"2016","journal-title":"ACS Chem. Biol."},{"issue":"16","key":"2026072709074035400_cit11","doi-asserted-by":"publisher","first-page":"5946","DOI":"10.1021\/ja400119t","article-title":"A Perfluoroaryl-Cysteine\nSN Ar Chemistry Approach to Unprotected Peptide Stapling","volume":"135","author":"Spokoyny","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026072709074035400_cit12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41467-022-27985-7","article-title":"Extendable\nStapling of Unprotected Peptides by Crosslinking Two Amines with O-Phthalaldehyde","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"issue":"31","key":"2026072709074035400_cit13","doi-asserted-by":"publisher","first-page":"12274","DOI":"10.1021\/jacs.9b03623","article-title":"Chemoselective\nPeptide\nCyclization and Bicyclization Directly on Unprotected Peptides","volume":"141","author":"Zhang","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"2026072709074035400_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420522","article-title":"Tyrosinase-Catalyzed\nPeptide Stapling Using Para-Amino Phenylalanine\nand Tyrosine Anchoring Residues","volume":"64","author":"Wang","year":"2025","journal-title":"Angew. Chem.,\nInt. Ed."},{"issue":"28","key":"2026072709074035400_cit15","doi-asserted-by":"publisher","first-page":"11099","DOI":"10.1039\/D4SC01244E","article-title":"Late-Stage Peptide Modification and\nMacrocyclization Enabled by Tertiary Amine Catalyzed Tryptophan Allylation","volume":"15","author":"Liu","year":"2024","journal-title":"Chem. Sci."},{"issue":"10","key":"2026072709074035400_cit16","doi-asserted-by":"publisher","first-page":"6675","DOI":"10.1021\/jacs.3c12879","article-title":"Site-Selective Polyfluoroaryl\nModification and Unsymmetric Stapling of Unprotected Peptides","volume":"146","author":"Wang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"2026072709074035400_cit17","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1021\/ol702228u","article-title":"Click Chemistry\nas a Macrocyclization\nTool in the Solid-Phase Synthesis of Small Cyclic Peptides","volume":"9","author":"Turner","year":"2007","journal-title":"Org. Lett."},{"issue":"24","key":"2026072709074035400_cit18","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.1021\/ja000563a","article-title":"An All-Hydrocarbon\nCross-Linking System for Enhancing\nthe Helicity and Metabolic Stability of Peptides","volume":"122","author":"Schafmeister","year":"2000","journal-title":"J. Am. Chem. Soc."},{"issue":"51","key":"2026072709074035400_cit19","doi-asserted-by":"publisher","first-page":"15410","DOI":"10.1002\/anie.201508416","article-title":"Double Strain-Promoted Macrocyclization\nfor the Rapid Selection of Cell-Active Stapled Peptides","volume":"54","author":"Lau","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"issue":"61","key":"2026072709074035400_cit20","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1039\/D4CC02442G","article-title":"Synthesis of Macrocyclic\nThiolactone Peptides via Photochemical\nIntramolecular Radical Acyl Thiol-Ene Ligation","volume":"60","author":"Benny","year":"2024","journal-title":"Chem. Commun."},{"issue":"3","key":"2026072709074035400_cit21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1021\/acschembio.9b00063","article-title":"Toolbox of Diverse Linkers for Navigating the Cellular\nEfficacy Landscape of Stapled Peptides","volume":"14","author":"Wu","year":"2019","journal-title":"ACS\nChem. Biol."},{"issue":"30","key":"2026072709074035400_cit22","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1002\/anie.201502607","article-title":"Acetone-Linked\nPeptides:\nA Convergent Approach for Peptide Macrocyclization and Labeling","volume":"54","author":"Assem","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"issue":"6","key":"2026072709074035400_cit23","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1021\/acs.accounts.8b00126","article-title":"Multicomponent Reactions\nin Ligation and Bioconjugation\nChemistry","volume":"51","author":"Reguera","year":"2018","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"2026072709074035400_cit24","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1038\/s41467-024-47188-6","article-title":"An All-in-One\nTetrazine Reagent for Cysteine-Selective\nLabeling and Bioorthogonal Activable Prodrug Construction","volume":"15","author":"He","year":"2024","journal-title":"Nat. Commun."},{"issue":"12","key":"2026072709074035400_cit25","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1021\/ja512880g","article-title":"Peptide\/Protein Stapling and Unstapling:\nIntroduction\nof s -Tetrazine, Photochemical Release, and Regeneration\nof the Peptide\/Protein","volume":"137","author":"Brown","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"13","key":"2026072709074035400_cit26","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1021\/ol301490h","article-title":"Design, Synthesis,\nand Photochemical Validation of\nPeptide Linchpins Containing the S,S -Tetrazine Phototrigger","volume":"14","author":"Abdo","year":"2012","journal-title":"Org. Lett."},{"issue":"3","key":"2026072709074035400_cit27","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3548","article-title":"Rapid, Traceless\nand Facile Peptide\nCyclization Enabled by Tetrazine-thiol Exchange","volume":"30","author":"Geers","year":"2024","journal-title":"J. Pept. Sci."},{"issue":"9","key":"2026072709074035400_cit28","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1039\/D3CB00062A","article-title":"Click\u2019n Lock: Rapid Exchange between Unsymmetric Tetrazines and Thiols\nfor Reversible, Chemoselective Functionalisation of Biomolecules with\non-Demand Bioorthogonal Locking","volume":"4","author":"Gavriel","year":"2023","journal-title":"RSC Chem. Biol."},{"issue":"29","key":"2026072709074035400_cit29","doi-asserted-by":"publisher","first-page":"16069","DOI":"10.1021\/jacs.3c04444","article-title":"Thiomethyltetrazines\nAre Reversible Covalent Cysteine Warheads Whose Dynamic Behavior Can\nBe \u201cSwitched Off\u201d via Bioorthogonal\nChemistry Inside Live Cells","volume":"145","author":"Tallon","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"2026072709074035400_cit30","doi-asserted-by":"publisher","first-page":"4893","DOI":"10.1021\/jacsau.5c00832","article-title":"The Unique\nProperties and Click Capacity of the Tetrazine Group Enable\nTetrazine Allyl Acetate to Serve as a Versatile Bis-Thiol Bioconjugation\nand Functionalization Agent","volume":"5","author":"Xu","year":"2025","journal-title":"JACS Au"},{"issue":"9","key":"2026072709074035400_cit31","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41557-022-00963-8","article-title":"Light-Activated\nTetrazines Enable Precision Live-Cell Bioorthogonal Chemistry","volume":"14","author":"Liu","year":"2022","journal-title":"Nat. Chem."},{"issue":"51","key":"2026072709074035400_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202501592","article-title":"Nitroreductase-Responsive\nBioorthogonal Tetrazine Conjugations in Cancer Cells","volume":"31","author":"Zhang","year":"2025","journal-title":"Chem.\u2500Eur. J."},{"issue":"20","key":"2026072709074035400_cit33","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1039\/b419015g","article-title":"Synthesis of Constrained\nHelical Peptides by Thioether\nLigation: Application to Analogs of Gp41","author":"Brunel","year":"2005","journal-title":"Chem.\nCommun."},{"issue":"10","key":"2026072709074035400_cit34","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1021\/jacs.0c09799","article-title":"Recapitulating the\nBinding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided\nby NMR, X-Ray Crystallography, and Machine Learning","volume":"143","author":"Ortet","year":"2021","journal-title":"J. Am. Chem. Soc."},{"issue":"30","key":"2026072709074035400_cit35","doi-asserted-by":"publisher","first-page":"11847","DOI":"10.1039\/D4SC03207A","article-title":"A Facile Strategy for the Construction\nof a Phage Display Cyclic Peptide Library for the Selection of Functional\nMacrocycles","volume":"15","author":"Xiang","year":"2024","journal-title":"Chem. Sci."},{"issue":"5","key":"2026072709074035400_cit36","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1476-5586(03)80046-5","article-title":"Isolation of a Colon\nTumor Specific Binding Peptide\nUsing Phage Display Selection","volume":"5","author":"Kelly","year":"2003","journal-title":"Neoplasia"},{"issue":"11","key":"2026072709074035400_cit37","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1007\/s00259-022-05842-5","article-title":"Preclinical\nEvaluation of FAP-2286 for Fibroblast Activation Protein Targeted\nRadionuclide Imaging and Therapy","volume":"49","author":"Zboralski","year":"2022","journal-title":"Eur. J. Nucl.\nMed. Mol. Imaging"},{"issue":"16","key":"2026072709074035400_cit38","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1021\/jm970832g","article-title":"N -Methylated\nCyclic RGD Peptides as Highly Active and Selective \u03b1V \u03b23 Integrin Antagonists","volume":"42","author":"Dechantsreiter","year":"1999","journal-title":"J. Med. Chem."},{"issue":"14","key":"2026072709074035400_cit39","doi-asserted-by":"publisher","first-page":"11789","DOI":"10.1021\/acs.jmedchem.4c00393","article-title":"Exploring the Potential\nof Cyclic Peptidyl Antitumor Agents Derived from Natural Macrocyclic\nPeptide Phakellistatin 13","volume":"67","author":"Li","year":"2024","journal-title":"J. Med.\nChem."},{"issue":"3","key":"2026072709074035400_cit40","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1046\/j.1432-1327.2000.01074.x","article-title":"Peptides with Antimicrobial\nActivity from Four Different Families Isolated from the Skins of the\nNorth American Frogs Rana Luteiventris, Rana Berlandieri and Rana Pipiens","volume":"267","author":"Goraya","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"2026072709074035400_cit41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jiec.2018.02.004","article-title":"Near-Infrared Fluorescent\nSorbitol Probe for Tumor Diagnosis in Vivo","volume":"64","author":"Lee","year":"2018","journal-title":"J. Ind. Eng. Chem."},{"issue":"12","key":"2026072709074035400_cit42","doi-asserted-by":"publisher","first-page":"12950","DOI":"10.1021\/acs.jmedchem.5c00847","article-title":"MMAE-Based Peptide-Drug\nConjugates Targeting GPC3 for\nPrecision Chemoradiotherapy in Hepatocellular Carcinoma","volume":"68","author":"Pan","year":"2025","journal-title":"J. Med. Chem."},{"key":"2026072709074035400_cit43","doi-asserted-by":"publisher","first-page":"100360","DOI":"10.1016\/j.coemr.2022.100360","article-title":"GLP-1 Analogues\nin Clinical Management\nof Obesity","volume":"25","author":"Agius","year":"2022","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"issue":"6","key":"2026072709074035400_cit44","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.chembiol.2015.05.009","article-title":"Hijacking\nthe E3 Ubiquitin Ligase\nCereblon to Efficiently Target BRD4","volume":"22","author":"Lu","year":"2015","journal-title":"Chem. Biol."},{"issue":"1","key":"2026072709074035400_cit45","doi-asserted-by":"publisher","first-page":"36938","DOI":"10.1038\/srep36938","article-title":"Quantitative Fluorescence\nSpectroscopy and Flow Cytometry Analyses of Cell-Penetrating Peptides\nInternalization Pathways: Optimization, Pitfalls, Comparison with\nMass Spectrometry Quantification","volume":"6","author":"Illien","year":"2016","journal-title":"Sci. Rep."},{"issue":"36","key":"2026072709074035400_cit46","doi-asserted-by":"publisher","first-page":"11360","DOI":"10.1021\/jacs.8b06144","article-title":"Cell Penetration\nProfiling Using\nthe Chloroalkane Penetration Assay","volume":"140","author":"Peraro","year":"2018","journal-title":"J. Am. Chem.\nSoc."},{"issue":"24","key":"2026072709074035400_cit47","doi-asserted-by":"publisher","first-page":"13003","DOI":"10.1073\/pnas.97.24.13003","article-title":"The Design, Synthesis, and Evaluation of Molecules\nThat Enable or Enhance Cellular Uptake: Peptoid Molecular Transporters","volume":"97","author":"Wender","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"2026072709074035400_cit48","doi-asserted-by":"publisher","first-page":"16281","DOI":"10.1021\/acsomega.8b02589","article-title":"Comparative Molecular\nTransporter Efficiency of Cyclic Peptides Containing Tryptophan and\nArginine Residues","volume":"3","author":"Hanna","year":"2018","journal-title":"ACS Omega"},{"issue":"2","key":"2026072709074035400_cit49","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1021\/cb3005275","article-title":"Efficient\nDelivery of Cyclic Peptides into Mammalian Cells with Short\nSequence Motifs","volume":"8","author":"Qian","year":"2013","journal-title":"ACS Chem. Biol."}],"container-title":["JACS Au"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacsau.6c00457","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jaaucr\/article-pdf\/6\/7\/3903\/65106253\/jacsau.6c00457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jaaucr\/article-pdf\/6\/7\/3903\/65106253\/jacsau.6c00457.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:23:56Z","timestamp":1785158636000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jaaucr\/article\/6\/7\/3903\/5157603\/Tetrazine-Enabled-Peptide-Macrocyclization-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,6,17]]},"published-print":{"date-parts":[[2026,7,27]]}},"URL":"https:\/\/doi.org\/10.1021\/jacsau.6c00457","relation":{},"ISSN":["2691-3704"],"issn-type":[{"value":"2691-3704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]}}}