{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:01:45Z","timestamp":1785160905386,"version":"3.55.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM149213"],"award-info":[{"award-number":["R35 GM149213"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Z-trisubstituted alkenes serve as key pharmaceutical building blocks and essential feedstocks for the selective synthesis and modification of drug molecules. Among these compounds, Z-trisubstituted alkenes that contain allylic tertiary amines are significant due to the increased solubility, lipophilicity, and metabolic stability provided by the tertiary amines. However, controlled synthesis of Z-trisubstituted alkenes with allylic tertiary amines has proven difficult, primarily due to thermodynamic challenges associated with the Z-isomer and the synthetic difficulties of accessing allylic tertiary amines. Here, we report a diene ligand-controlled rhodium-catalyzed amination of 1,1-disubstituted fluoromethyl allylic trichloroacetimidates with secondary aliphatic and aryl amines to afford the Z-trisubstituted alkenes bearing allylic tertiary amines in good yields (45\u201398% yields) and excellent selectivity (E\/Z &amp;gt; 1:20). A mechanistic investigation was conducted using both experimental and computational Density Functional Theory (DFT). DFT calculations showed a preference for bidentate coordination of the diene ligand to the rhodium, which is needed for the ionization of the 1,1-disubstituted fluoromethyl allylic trichloroacetimidate to generate anti- and syn-\u03c0-allyl-rhodium intermediates. The E- and Z-differentiation occurs prior to nucleophilic attack of the secondary amines onto the more reactive \u03c0-allyl intermediates. The syn \u03c0-allyl intermediates lead to the minor E-trisubstituted alkene product, whereas the more reactive anti intermediates give the major Z-product. DFT calculations showed that the rate of conversion between reactive anti and syn \u03c0-allyl intermediates via \u03c0\u2013\u03c3\u2013\u03c0 interconversion was faster than the rate of nucleophilic attack, establishing a Curtin\u2013Hammett condition. The fluoromethyl substrate was essential for the linear regioselectivity, as it induced a crucial hydrogen bonding interaction between the 1,1-disubstituted fluoromethyl allylic trichloroacetimidate and the secondary amine nucleophile. Overall, we anticipate that this methodology will be broadly applicable to the development of medically relevant Z-alkenes bearing allylic tertiary amines. The mechanistic insights gained will also serve as a foundation for addressing the challenges involved in other classes of Z-configured alkenes.<\/jats:p>","DOI":"10.1021\/jacsau.6c00604","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:02:41Z","timestamp":1783072961000},"page":"4096-4106","source":"Crossref","is-referenced-by-count":0,"title":["<i>Z<\/i>\n                    -Selective Synthesis of Trisubstituted\nAlkenes Bearing Allylic Tertiary Amines via Rhodium-Catalyzed Allylic\nAmination of 1,1-Disubstituted Fluoromethyl Trichloroacetimidates"],"prefix":"10.1021","volume":"6","author":[{"given":"Felix O.","family":"Chukwu","sequence":"first","affiliation":[{"name":"Wayne State University , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Rani","sequence":"additional","affiliation":[{"name":"Wayne State University , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rollanda","family":"Tella","sequence":"additional","affiliation":[{"name":"Wayne State University , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-2821","authenticated-orcid":true,"given":"H. Bernhard","family":"Schlegel","sequence":"additional","affiliation":[{"name":"Wayne State University , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-8439","authenticated-orcid":true,"given":"Hien M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Wayne State University , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"16","key":"2026072709074715300_cit1","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.3390\/molecules30163370","article-title":"Trisubstituted Alkenes as Valuable Building Blocks","volume":"30","author":"Tobrman","year":"2025","journal-title":"Molecules"},{"key":"2026072709074715300_cit2","volume-title":"Conjugate\nAddition Reactions In Organic Synthesis","author":"Perlmutter","year":"2013"},{"issue":"36","key":"2026072709074715300_cit3","doi-asserted-by":"publisher","first-page":"11930","DOI":"10.1021\/jacs.6b07291","article-title":"Enantio-and Regioselective Ir-Catalyzed\nHydrogenation of Di-and Trisubstituted Cycloalkenes","volume":"138","author":"Peters","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"43","key":"2026072709074715300_cit4","doi-asserted-by":"publisher","first-page":"14226","DOI":"10.1021\/jacs.6b09649","article-title":"Enantioselective\nPalladium-Catalyzed Alkenylation of\nTrisubstituted Alkenols to Form Allylic Quaternary Centers","volume":"138","author":"Patel","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"2026072709074715300_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401469","article-title":"Heteroaryl\nGroup Containing Trisubstituted Alkenes:\nSynthesis and Anti-tumor Activity","volume":"21","author":"Li","year":"2024","journal-title":"Chem. Biodiversity"},{"issue":"24","key":"2026072709074715300_cit6","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis\nof the Structural Diversity,\nSubstitution Patterns, and Frequency of Nitrogen Heterocycles among\nUS FDA Approved Pharmaceuticals: Miniperspective","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. Med. Chem."},{"issue":"5","key":"2026072709074715300_cit7","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1021\/acs.chemrev.9b00462","article-title":"New Strategies\nfor the Transition-Metal\nCatalyzed Synthesis of Aliphatic Amines","volume":"120","author":"Trowbridge","year":"2020","journal-title":"Chem.\nRev."},{"issue":"8","key":"2026072709074715300_cit8","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1002\/cmdc.200700059","article-title":"Predicting\nand Tuning Physicochemical Properties in Lead Optimization: Amine\nBasicities","volume":"2","author":"Morgenthaler","year":"2007","journal-title":"ChemMedchem"},{"issue":"1","key":"2026072709074715300_cit9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s44160-024-00658-7","article-title":"Kinetically Controlled\nZ-Alkene Synthesis Using Iron-Catalysed\nAllene Dialkylation","volume":"4","author":"Tan","year":"2025","journal-title":"Nat. Synth"},{"issue":"32","key":"2026072709074715300_cit10","doi-asserted-by":"publisher","first-page":"17557","DOI":"10.1021\/jacs.3c06479","article-title":"Stereoselective\nSynthesis of Trisubstituted Alkenes\nvia Copper Hydride-Catalyzed Alkyne Hydroalkylation","volume":"145","author":"Kutateladze","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"7685","key":"2026072709074715300_cit11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature25002","article-title":"Synthesis\nof E-and Z-Trisubstituted Alkenes by Catalytic Cross-Metathesis","volume":"552","author":"Nguyen","year":"2017","journal-title":"Nature"},{"key":"2026072709074715300_cit12","doi-asserted-by":"crossref","DOI":"10.1002\/9783527826186","volume-title":"Methodologies\nin Amine\nSynthesis: Challenges and Applications","author":"Ricci","year":"2021"},{"issue":"28","key":"2026072709074715300_cit13","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1039\/D3CC00439B","article-title":"Recent Advances in\nthe Synthesis of Chiral \u03b1-Tertiary Amines via Transition-Metal\nCatalysis","volume":"59","author":"Xu","year":"2023","journal-title":"Chem. Commun."},{"issue":"27","key":"2026072709074715300_cit14","doi-asserted-by":"publisher","first-page":"10352","DOI":"10.1021\/jacs.1c04261","article-title":"Palladium-Catalyzed\n\u03b3,\u0393\u2032-Diarylation\nof Free Alkenyl Amines","volume":"143","author":"Landge","year":"2021","journal-title":"J. Am. Chem. Soc."},{"issue":"36","key":"2026072709074715300_cit15","doi-asserted-by":"publisher","first-page":"11970","DOI":"10.1021\/jacs.6b07382","article-title":"Stereoselective\nand Versatile Preparation of Tri- and Tetrasubstituted Allylic Amine\nScaffolds under Mild Conditions","volume":"138","author":"Guo","year":"2016","journal-title":"J. Am. Chem.\nSoc."},{"issue":"22","key":"2026072709074715300_cit16","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.1021\/om020680+","article-title":"Effects of Bidentate Phosphine Ligands\non s Yn \u2013 Anti Isomerization in \u03c0-Allylpalladium\nComplexes","volume":"21","author":"Ogasawara","year":"2002","journal-title":"Organometallics"},{"issue":"1","key":"2026072709074715300_cit17","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1021\/ja00782a080","article-title":"New Synthetic\nReactions. Allylic Alkylation","volume":"95","author":"Trost","year":"1973","journal-title":"J. Am. Chem.\nSoc."},{"issue":"49","key":"2026072709074715300_cit18","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1016\/S0040-4039(00)71674-1","article-title":"Organic Syntheses by Means of Noble\nMetal Compounds XVII. Reaction of \u03c0-Allylpalladium Chloride\nwith Nucleophiles","volume":"6","author":"Tsuji","year":"1965","journal-title":"Tetrahedron Lett."},{"issue":"6590","key":"2026072709074715300_cit19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1126\/science.abn8382","article-title":"Allylic\nC\u2013H Amination Cross-Coupling Furnishes\nTertiary Amines by Electrophilic Metal Catalysis","volume":"376","author":"Ali","year":"2022","journal-title":"Science"},{"issue":"36","key":"2026072709074715300_cit20","doi-asserted-by":"publisher","first-page":"32786","DOI":"10.1021\/jacs.5c08883","article-title":"C(Sp3)H\/N(Sp2) Cross-Coupling Reaction for the Synthesis of\nTertiary Arylamines via Fluxional SOX\u00b7Pd(II) Catalysis","volume":"147","author":"Budaitis","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"33","key":"2026072709074715300_cit21","doi-asserted-by":"publisher","first-page":"18497","DOI":"10.1021\/jacs.3c04968","article-title":"Merging of\nLight\/Dark Palladium Catalytic Cycles Enables Multicomponent Tandem\nAlkyl Heck\/Tsuji\u2013Trost Homologative Amination Reaction toward\nAllylic Amines","volume":"145","author":"Kvasovs","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"6625","key":"2026072709074715300_cit22","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1126\/science.abq1274","article-title":"Asymmetric Intermolecular Allylic\nC\u2013H Amination of Alkenes with Aliphatic Amines","volume":"378","author":"Pak Shing Cheung","year":"2022","journal-title":"Science"},{"issue":"10","key":"2026072709074715300_cit23","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/s41557-022-01023-x","article-title":"Palladium-Catalysed\nSelective Oxidative Amination of\nOlefins with Lewis Basic Amines","volume":"14","author":"Jin","year":"2022","journal-title":"Nat. Chem."},{"issue":"2","key":"2026072709074715300_cit24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1021\/ol990033n","article-title":"Complete Retention of Z Geometry in Allylic Substitution Catalyzed\nby an Iridium Complex","volume":"1","author":"Takeuchi","year":"1999","journal-title":"Org. Lett."},{"issue":"18","key":"2026072709074715300_cit25","doi-asserted-by":"publisher","first-page":"14161","DOI":"10.1021\/acscatal.4c03771","article-title":"Interception\nof Transient Anti-Allyl\u2013Ir Species\nwith Cu\u2013Azomethine Ylide: Mechanistic Origins of Z-Selectivity\nin an Asymmetric Allylation Reaction","volume":"14","author":"Xu","year":"2024","journal-title":"ACS Catal."},{"issue":"3","key":"2026072709074715300_cit26","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1021\/jacs.4c15635","article-title":"Interrupting\nAssociative \u03c0\u2013\u03c3\u2013\u03c0 Isomerization Enables\nZ-Retentive Asymmetric Tsuji\u2013Trost Reaction","volume":"147","author":"Liu","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"2026072709074715300_cit27","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/s41929-022-00879-z","article-title":"Structurally Defined\nAnti-\u03c0-Allyliridium Complexes Catalyse Z-Retentive Asymmetric\nAllylic Alkylation of Oxindoles","volume":"5","author":"Jiang","year":"2022","journal-title":"Nat. Catal."},{"issue":"11","key":"2026072709074715300_cit28","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.1021\/jacs.2c01103","article-title":"Enantioselective\nSynthesis of Medium-Sized-Ring Lactones via Iridium-Catalyzed Z-Retentive\nAsymmetric Allylic Substitution Reaction","volume":"144","author":"Ding","year":"2022","journal-title":"J.\nAm. Chem. Soc."},{"issue":"25","key":"2026072709074715300_cit29","doi-asserted-by":"publisher","first-page":"22024","DOI":"10.1021\/jacs.5c05792","article-title":"Iridium-Catalyzed Z -Selective Asymmetric Allylic Substitution Reaction via Z\/E Kinetic Resolution","volume":"147","author":"Hou","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"6712","key":"2026072709074715300_cit30","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1126\/science.ado4936","article-title":"Stereodivergent Access\nto Non-Natural \u03b1-Amino\nAcids via Enantio- and Z\/E -Selective\nCatalysis","volume":"385","author":"Li","year":"2024","journal-title":"Science"},{"issue":"18","key":"2026072709074715300_cit31","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1021\/acs.accounts.3c00341","article-title":"Taking Olefin\nMetathesis to the Limit: Stereocontrolled Synthesis of Trisubstituted\nAlkenes","volume":"56","author":"Hoveyda","year":"2023","journal-title":"Acc. Chem. Res."},{"issue":"12","key":"2026072709074715300_cit32","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1002\/cctc.201300688","article-title":"Z Selectivity:\nRecent Advances in\nOne of the Current Major Challenges of Olefin Metathesis","volume":"5","author":"Shahane","year":"2013","journal-title":"ChemCatchem"},{"issue":"2","key":"2026072709074715300_cit33","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1021\/acscatal.7b03786","article-title":"Asymmetric Synthesis\nof Allylic Fluorides via Fluorination of Racemic Allylic Trichloroacetimidates\nCatalyzed by a Chiral Diene-Iridium Complex","volume":"8","author":"Mixdorf","year":"2018","journal-title":"ACS Catal."},{"issue":"23","key":"2026072709074715300_cit34","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1002\/ejoc.201402097","article-title":"Transition-Metal-Catalyzed\nAllylic\nSubstitutions of Trichloroacetimidates","volume":"2014","author":"Arnold","year":"2014","journal-title":"Eur.\nJ. Org. Chem."},{"issue":"2","key":"2026072709074715300_cit35","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1021\/acs.orglett.4c04289","article-title":"Rhodium-Catalyzed\nAllylic Amination\nfor the Enantioselective Synthesis of Tertiary \u03b2-Fluoroamines","volume":"27","author":"Chukwu","year":"2025","journal-title":"Org. Lett."},{"issue":"36","key":"2026072709074715300_cit36","doi-asserted-by":"publisher","first-page":"19642","DOI":"10.1021\/jacs.3c04211","article-title":"Scope and\nMechanistic\nProbe into Asymmetric Synthesis of \u03b1-Trisubstituted-\u03b1-Tertiary\nAmines by Rhodium Catalysis","volume":"145","author":"Arachchi","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"2026072709074715300_cit37","doi-asserted-by":"publisher","first-page":"8380","DOI":"10.1021\/ja302223p","article-title":"Rhodium-Catalyzed Dynamic Kinetic Asymmetric Transformations\nof Racemic Tertiary Allylic Trichloroacetimidates with Anilines","volume":"134","author":"Arnold","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"2026072709074715300_cit38","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1021\/ja00740a011","article-title":"Organometallic\nConformational Equilibriums.\nX. Steric Factors and Their Mechanistic Implications in. Pi.-Allyl\n(Amine) Chloropalladium (II) Complexes","volume":"93","author":"Faller","year":"1971","journal-title":"J. Am.\nChem. Soc."},{"issue":"1","key":"2026072709074715300_cit39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1021\/ed063p42","article-title":"The Curtin-Hammett\nPrinciple and the Winstein-Holness Equation: New Definition and Recent\nExtensions to Classical Concepts","volume":"63","author":"Seeman","year":"1986","journal-title":"J. Chem. Educ."},{"key":"2026072709074715300_cit40","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/9780470147276.ch4","article-title":"Kinetic Resolution","volume":"18","author":"Kagan","year":"1988","journal-title":"Top. Stereochem."},{"issue":"2","key":"2026072709074715300_cit41","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1021\/ja00809a054","article-title":"Thermal\nand Mercuric Ion Catalyzed [3,3]-Sigmatropic Rearrangement of Allylic\nTrichloroacetimidates. 1,3 Transposition of Alcohol and Amine Functions","volume":"96","author":"Overman","year":"1974","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"2026072709074715300_cit42","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1021\/ja00426a038","article-title":"A General\nMethod for the Synthesis of Amines by the Rearrangement of Allylic\nTrichloroacetimidates. 1,3 Transposition of Alcohol and Amine Functions","volume":"98","author":"Overman","year":"1976","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"2026072709074715300_cit43","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1021\/ol202313y","article-title":"Synthesis\nof \u03b1,\u03b1-Disubstituted\nAryl Amines by Rhodium-Catalyzed Amination of Tertiary Allylic Trichloroacetimidates","volume":"13","author":"Arnold","year":"2011","journal-title":"Org. Lett."},{"issue":"20","key":"2026072709074715300_cit44","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1021\/ol1019025","article-title":"Rhodium-Catalyzed\nRegioselective\nAmination of Secondary Allylic Trichloroacetimidates with Unactivated\nAromatic Amines","volume":"12","author":"Arnold","year":"2010","journal-title":"Org. Lett."},{"issue":"11","key":"2026072709074715300_cit45","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.2174\/1385272823666190624145039","article-title":"Novel Chiral Ligands\nfor Palladium-Catalyzed Asymmetric Allylic Alkylation\/Asymmetric\nTsuji-Trost Reaction: A Review","volume":"23","author":"Noreen","year":"2019","journal-title":"Curr. Org. Chem."},{"issue":"48","key":"2026072709074715300_cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314843","article-title":"Rhodium-Catalyzed Asymmetric Synthesis of 1,2-Disubstituted\nAllylic Fluorides","volume":"62","author":"Usman","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"issue":"17","key":"2026072709074715300_cit47","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1002\/adsc.202100575","article-title":"Iridium-Catalyzed Enantioselective Allylic Substitutions\nof Racemic, Branched Trichloroacetimidates with Heteroatom Nucleophiles:\nFormation of Allylic C\u2013O, C\u2013N, and C\u2013S Bonds","volume":"363","author":"Arachchi","year":"2021","journal-title":"Adv. Synth. Catal."},{"issue":"24","key":"2026072709074715300_cit48","doi-asserted-by":"publisher","first-page":"4482","DOI":"10.1002\/anie.200703612","article-title":"Chiral Olefins as Steering Ligands\nin Asymmetric Catalysis","volume":"47","author":"Defieber","year":"2008","journal-title":"Angew. Chem., Int.\nEd."},{"key":"2026072709074715300_cit49","volume-title":"Homogeneous Hydrogenation","author":"Chaloner","year":"2013"},{"issue":"26","key":"2026072709074715300_cit50","doi-asserted-by":"publisher","first-page":"5406","DOI":"10.1021\/om034218g","article-title":"Versatility\nof Cyclooctadiene Ligands in Iridium Chemistry and Catalysis","volume":"22","author":"Marti\u0301n","year":"2003","journal-title":"Organometallics"},{"issue":"10","key":"2026072709074715300_cit51","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1107\/S0365110X62002479","article-title":"Crystal Structure\nof the Dimer of Rhodium Chloride\n1,5-Cyclooctadiene","volume":"15","author":"Ibers","year":"1962","journal-title":"Acta Crystallogr."},{"issue":"2","key":"2026072709074715300_cit52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1021\/cr00054a001","article-title":"Effect\nof Conformational Change on Reactivity in Organic Chemistry. Evaluations,\nApplications, and Extensions of Curtin-Hammett Winstein-Holness Kinetics","volume":"83","author":"Seeman","year":"1983","journal-title":"Chem. Rev."},{"key":"2026072709074715300_cit53","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-32099-6","volume-title":"New Discoveries\nOn The \u03b2-Hydride Elimination","author":"G\u00f8gsig","year":"2012"},{"issue":"13","key":"2026072709074715300_cit54","doi-asserted-by":"publisher","first-page":"4459","DOI":"10.1021\/ja7106096","article-title":"Scope and Mechanism\nof Formal SN2\n\u2018Substitution Reactions of a Monomeric Imidozirconium Complex\nwith Allylic Electrophiles","volume":"130","author":"Lalic","year":"2008","journal-title":"J. Am. Chem. 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