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The direct functionalization of pyridines via C\u2013H activation provides a straightforward approach to access valuable substitution patterns and functional groups. While ortho- and para-functionalizations are well developed, meta-selective functionalization is far more challenging, owing to the inherent electronic properties of the pyridine ring. When it comes to meta-selective functionalization of pyridine, much has been accomplished, particularly in C\u2013C bond formation. On the other hand, when a C-heteroatom (N, O, S and halogen) bond is envisioned, there remains significant room for development. In the last two to three years, considerable progress has been made in this topic, with a variety of approaches being reported. In this Perspective, we outline a selection of the most recent advances in pyridine meta-functionalization featuring amination, hydroxylation, thiolation and halogenation by means of emerging strategies that offer elegant approaches to otherwise elusive bond formations.<\/jats:p>","DOI":"10.1021\/jacsau.6c00675","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:08:44Z","timestamp":1784599724000},"page":"4367-4379","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Strategies\nfor\n                    <i>meta<\/i>\n                    -Heteroatom\nFunctionalization of Pyridines"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-4374","authenticated-orcid":true,"given":"Telmo N.","family":"Francisco","sequence":"first","affiliation":[{"name":"University of Aveiro , , ,","place":["Aveiro, Portugal, 3810-193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":true,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"University of Aveiro , , ,","place":["Aveiro, Portugal, 3810-193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-3316","authenticated-orcid":true,"given":"He\u0301lio M. T.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"University of Aveiro , , ,","place":["Aveiro, Portugal, 3810-193"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026083023170285700_cit1","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1021\/ar500112b","article-title":"Pyridine\nCoordination Chemistry for Molecular Assemblies on Surfaces","volume":"47","author":"de Ruiter","year":"2014","journal-title":"Acc. Chem. 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