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The products yielded at both sites prefer to accumulate within the coacervates. This internal crowding disrupts local physicochemical conditions, challenging the stability of the coacervate to maintain reaction rates. We demonstrate that the abiological coacervate formed by liquid\u2013liquid phase separation induced by polycation\u2013multivalent anion electrostatic interactions could tolerate an external temperature span of 19\u201341 \u00b0C and pH range of 4\u201311. Internal heat generated from hydrazone bond formation enhances the fluidity of coacervate microdroplets, which increases the mobility of concentrated substrates and results in a 14.5-fold increase in production rate. We further revealed that these coacervates buffer inner pH oscillations through amino protonation and phosphate-proton interactions performed with a dual-enzyme cascade reaction. The dynamic thermal and pH adaptability of this abiological coacervate microreactor stabilizes enzyme conformations, ensuring consistent reaction rates and product yields, highlighting its potential in industrial biocatalysis and precision medicine.<\/jats:p>","DOI":"10.1021\/jacsau.6c00775","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:28:01Z","timestamp":1784053681000},"page":"4301-4309","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive Coacervate\nMicroreactors with Broad pH\/Thermal\nTolerance for Reaction Acceleration"],"prefix":"10.1021","volume":"6","author":[{"given":"Fei","family":"Zhang","sequence":"first","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wei","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongqing","family":"Yue","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-5819","authenticated-orcid":true,"given":"Zejun","family":"Wang","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"issue":"3","key":"2026072709065985800_cit1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","article-title":"Considerations and Challenges in\nStudying Liquid-Liquid Phase Separation and Biomolecular Condensates","volume":"176","author":"Alberti","year":"2019","journal-title":"Cell"},{"issue":"6431","key":"2026072709065985800_cit2","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1126\/science.aau6313","article-title":"Stoichiometry\ncontrols\nactivity of phase-separated clusters of actin signaling proteins","volume":"363","author":"Case","year":"2019","journal-title":"Science"},{"issue":"11","key":"2026072709065985800_cit3","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/s41556-023-01265-y","article-title":"Keeping membraneless\norganelles apart","volume":"25","author":"Schmit","year":"2023","journal-title":"Nat.\nCell Bio."},{"issue":"10","key":"2026072709065985800_cit4","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/s41557-022-01043-7","article-title":"Multiphase model membraneless organelles","volume":"14","author":"Wu","year":"2022","journal-title":"Nat.\nChem."},{"issue":"6477","key":"2026072709065985800_cit5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay7108","article-title":"Endoplasmic\nreticulum contact sites regulate the dynamics of membraneless organelles","volume":"367","author":"Lee","year":"2020","journal-title":"Science"},{"issue":"1","key":"2026072709065985800_cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32941-6","article-title":"Signal processing\nand generation of bioactive nitric oxide in a model prototissue","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. 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