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Through-space steric interactions induce asymmetric torsion in the CPP backbone, generating a strained nanohoop with the lowest-energy conformer (\u0394G = \u22122.9 kcal mol\u20131, corresponding to &amp;gt;99% population of the preferred conformer at 293 K). Temperature- and solvent-dependent circular dichroism (CD) spectra exhibit minimal signal variation, in marked contrast to conventional dynamic chiral systems and the monomeric precursor. Variable-temperature NMR reveals rapid interconversion (\u0394G\u2021 = 12.4 kcal mol\u20131), confirming fast kinetics that enable equilibration to the thermodynamically favored twisted conformation. Single-crystal X-ray diffraction and time-dependent density-functional theory (TD-DFT) calculations, including model compounds devoid of BINOL chromophores, unambiguously assign the intense Cotton effects to torsionally distorted CPP-centered \u03c0\u2013\u03c0* transitions.<\/jats:p>","DOI":"10.1021\/jacsau.6c01002","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:02:03Z","timestamp":1787072523000},"page":"5328-5335","source":"Crossref","is-referenced-by-count":0,"title":["Thermodynamic Locking\nof Conformational Chirality\nin a [9]Cycloparaphenylene"],"prefix":"10.1021","volume":"6","author":[{"given":"Zhi","family":"Zhang","sequence":"first","affiliation":[{"name":"Westlake University , , , ,","place":["Hangzhou, Zhejiang, P. R. China, 310030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanli","family":"Shen","sequence":"additional","affiliation":[{"name":"Westlake University , , , ,","place":["Hangzhou, Zhejiang, P. R. 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