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Herein, we report a photocatalytic strategy for the direct conversion of readily available furans to N-methylpyrroles. The reaction efficiency was markedly improved compared to the first-generation catalytic protocol through the development of tailored photocatalysts. Combining skeletal editing with continuous-flow photochemistry, this method provides efficient access to N-methylpyrroles under mild conditions while avoiding preformed N\u2013H pyrrole substrates and conventional methylating agents. The utility of the protocol was further demonstrated through the late-stage diversification of structurally complex molecules.<\/jats:p>","DOI":"10.1021\/jacsau.6c01035","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:02:01Z","timestamp":1786111321000},"page":"4811-4818","source":"Crossref","is-referenced-by-count":2,"title":["Direct Access to the Simplest\n                    <i>N<\/i>\n                    -Substituted\nPyrroles from Furans Enabled by Tailored Photocatalysts"],"prefix":"10.1021","volume":"6","author":[{"given":"Hyeonbhin","family":"Byeon","sequence":"first","affiliation":[{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojin","family":"Hong","sequence":"additional","affiliation":[{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9541-9749","authenticated-orcid":true,"given":"Da Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjee","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeyang","family":"Ha","sequence":"additional","affiliation":[{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Ulsan National Institute of Science and Technology , , ,","place":["Ulsan, Republic of Korea, 44919"]},{"name":"InnoCORE AI Co-Research & Education for Innovative Drug (AI-CRED) Institute KAIST , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-0635","authenticated-orcid":true,"given":"Yoonsu","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]},{"name":"InnoCORE AI Co-Research & Education for Innovative Drug (AI-CRED) Institute KAIST , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"2026083023170601600_cit1","doi-asserted-by":"publisher","first-page":"5061","DOI":"10.1021\/jm100112j","article-title":"A Medicinal Chemist\u2019s Guide\nto Molecular Interactions","volume":"53","author":"Bissantz","year":"2010","journal-title":"J. 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Chem."},{"key":"2026083023170601600_cit5","volume-title":"The Synthesis and\nthe Physical and Chemical Aspects of the Pyrrole Ring","author":"Jones","year":"1990"},{"key":"2026083023170601600_cit6","article-title":"The Chemistry\nof Pyrroles","volume-title":"Organic Chemistry: A Series\nof Monographs","author":"Jones","year":"2013"},{"key":"2026083023170601600_cit7","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2174\/1389200023337360","article-title":"On the\nDiversity of Oxidative Bioactivation Reactions on Nitrogen-Containing\nXenobiotics","volume":"3","author":"Kalgutkar","year":"2002","journal-title":"Curr. Drug Metab."},{"key":"2026083023170601600_cit8","doi-asserted-by":"publisher","first-page":"15233","DOI":"10.1039\/C4RA15710A","article-title":"Pyrrole: a\nresourceful small molecule in key medicinal hetero-aromatics","volume":"5","author":"Bhardwaj","year":"2015","journal-title":"RSC Adv."},{"key":"2026083023170601600_cit9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.adq6245","article-title":"Photocatalytic\nfuran-to-pyrrole conversion","volume":"386","author":"Kim","year":"2024","journal-title":"Science"},{"key":"2026083023170601600_cit10","doi-asserted-by":"publisher","first-page":"8588","DOI":"10.1021\/acs.orglett.6c02036","article-title":"Skeletal\nand Peripheral Editing of Pyridinium Salts into Fully Substituted\nPyrroles","volume":"28","author":"Li","year":"2026","journal-title":"Org. 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