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During acute myocardial ischemia, the lack of oxygen switches the cell metabolism to anaerobic respiration, with lactate accumulation, ATP depletion, Na+ and Ca2+ overload, and inhibition of myocardial contractile function, which drastically modifies the lipid, protein, and small metabolite profile in the myocardium. Imaging mass spectrometry (IMS) is a powerful technique to comprehensively elucidate the spatial distribution patterns of lipids, peptides, and proteins in biological tissue sections. In this work, we demonstrate an application of multimodal chemical imaging using matrix-assisted laser desorption\/ionization mass spectrometry (MALDI-MS), which provided comprehensive molecular information in situ within the same mouse heart tissue sections with myocardial infarction. MALDI-IMS (at 30 \u03bcm per pixel) revealed infarct-associated spatial alterations of several lipid species of sphingolipids, glycerophospholipids, lysophospholipids, and cardiolipins along with the acyl carnitines. Further, we performed multimodal MALDI-IMS (IMS3) where dual polarity lipid imaging was combined with subsequent protein MALDI-IMS analysis (at 30 \u03bcm per pixel) within the same tissue sections, which revealed accumulations of core histone proteins H4, H2A, and H2B along with post-translational modification products, acetylated H4 and H2A, on the borders of the infarcted region. This methodology allowed us to interpret the lipid and protein molecular pathology of the very same infarcted region in a mouse model of myocardial infarction. Therefore, the presented data highlight the potential of multimodal MALDI imaging mass spectrometry of the same tissue sections as a powerful approach for simultaneous investigation of spatial infarct-associated lipid and protein changes of myocardial infarction.<\/jats:p>","DOI":"10.1021\/jasms.0c00245","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T16:42:05Z","timestamp":1599583325000},"page":"2133-2142","source":"Crossref","is-referenced-by-count":55,"title":["Multimodal MALDI Imaging Mass Spectrometry Reveals\nSpatially Correlated Lipid and Protein Changes in Mouse Heart with\nAcute Myocardial Infarction"],"prefix":"10.1021","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3345-5602","authenticated-orcid":true,"given":"Ibrahim","family":"Kaya","sequence":"first","affiliation":[{"name":"Sahlgrenska Academy at the University of Gothenburg , , ,","place":["Mo\u0308lndal, Sweden, 431 80"]},{"name":"University of Gothenburg , , ,","place":["Gothenburg, Sweden, 405 30"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"Sa\u0308mfors","sequence":"additional","affiliation":[{"name":"University of Gothenburg , , ,","place":["Gothenburg, Sweden, 405 30"]},{"name":"Institute of Medicine at University of Gothenburg and Sahlgrenska University Hospital , , ,","place":["Gothenburg, Sweden, 405 30"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Levin","sequence":"additional","affiliation":[{"name":"Institute of Medicine at University of Gothenburg and Sahlgrenska University Hospital , , ,","place":["Gothenburg, Sweden, 405 30"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bore\u0301n","sequence":"additional","affiliation":[{"name":"Institute of Medicine at University of Gothenburg and Sahlgrenska University Hospital , , ,","place":["Gothenburg, Sweden, 405 30"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-8571","authenticated-orcid":true,"given":"John S.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"University of Gothenburg , , ,","place":["Gothenburg, Sweden, 405 30"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"issue":"9360","key":"2026090306155612000_cit1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S0140-6736(03)12712-2","article-title":"Acute myocardial\ninfarction","volume":"361","author":"Boersma","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"2026090306155612000_cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.2003.055095","article-title":"Energy metabolism\nin heart failure","volume":"555","author":"Ventura-Clapier","year":"2004","journal-title":"J. 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