{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:57:42Z","timestamp":1791860262990,"version":"4.3.4"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA236097"],"award-info":[{"award-number":["CA236097"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM105249"],"award-info":[{"award-number":["GM105249"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Soc. Mass Spectrom."],"published-print":{"date-parts":[[2021,4,7]]},"DOI":"10.1021\/jasms.0c00473","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T01:23:36Z","timestamp":1614302616000},"page":"977-988","source":"Crossref","is-referenced-by-count":165,"title":["Highly Multiplexed Immunohistochemical MALDI-MS Imaging of Biomarkers in Tissues"],"prefix":"10.1021","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-3089","authenticated-orcid":true,"given":"Gargey","family":"Yagnik","sequence":"first","affiliation":[{"name":"AmberGen, Inc., 313 Pleasant Street, Watertown, Massachusetts 02472, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Liu","sequence":"additional","affiliation":[{"name":"AmberGen, Inc., 313 Pleasant Street, Watertown, Massachusetts 02472, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Rothschild","sequence":"additional","affiliation":[{"name":"AmberGen, Inc., 313 Pleasant Street, Watertown, Massachusetts 02472, United States"},{"name":"Molecular Biophysics Laboratory, Department of Physics and Photonics Center, Boston University, Boston, Massachusetts 02215, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Lim","sequence":"additional","affiliation":[{"name":"AmberGen, Inc., 313 Pleasant Street, Watertown, Massachusetts 02472, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.09.007"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.08.016"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-289-2_11"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028035"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-328-8_17"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.382"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68760"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28944-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15798-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1459-3_14"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701262"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13942-8"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800509"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31657"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.010"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300136110"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1250"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10026"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2869"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2016.11.002"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ac970888i"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b04733"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104404"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3108"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4071"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2895"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200701150"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/pr0700044"},{"issue":"8","key":"ref29\/cit29","first-page":"233","volume":"16","author":"El Ayed M.","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.R800016-MCP200"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3488"},{"key":"ref32\/cit32","unstructured":"Fluidigm.  Maxpar X8 Antibody Labeling Quick Reference, rev.\n01, 2019. https:\/\/www.fluidigm.com\/binaries\/content\/documents\/fluidigm\/resources\/maxpar-x8-antibody-labeling-quick-reference-fldm-00015-rev01\/maxpar-x8-antibody-labeling-quick-reference-fldm-00015-rev01\/fluidigm%3Afile (accessed 2020)."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7590"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2836"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-022X(98)00027-X"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-016-1422-0"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2007.06.010"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/srep26125"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6754"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16797-1"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2015-7-2-42-47"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90146-6"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14152"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01679.x"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2018.1421071"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.116"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00049"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.456"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5858"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.2009.954123"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02434"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183214"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04573.x"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1111\/his.12228"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1991.tb01278.x"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001001"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s004290100210"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056418"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.2916"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5131(03)01172-5"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-6668-z"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051076"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-019-03036-5"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.04.005"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000179845.53213.39"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.09.046"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2330"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-008-8022-3"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13897"}],"container-title":["Journal of the American Society for Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.0c00473","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.0c00473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T03:58:29Z","timestamp":1682567909000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jasms.0c00473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,7]]}},"alternative-id":["10.1021\/jasms.0c00473"],"URL":"https:\/\/doi.org\/10.1021\/jasms.0c00473","relation":{},"ISSN":["1044-0305","1879-1123"],"issn-type":[{"value":"1044-0305","type":"print"},{"value":"1879-1123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,25]]}}}