{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:04:02Z","timestamp":1785942242225,"version":"3.56.0"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1502600"],"award-info":[{"award-number":["2021YFA1502600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1505800"],"award-info":[{"award-number":["2022YFA1505800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92045301"],"award-info":[{"award-number":["92045301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAS Key Technology Talent Program and USTC Research Funds of the Double First-Class Initiative","award":["2310002010"],"award-info":[{"award-number":["2310002010"]}]},{"name":"Science and Technology Plan Project of China Tobacco Anhui Industrial Co., Ltd.","award":["2022340000340020"],"award-info":[{"award-number":["2022340000340020"]}]},{"name":"Key Project of Anhui Province Science and Technology Innovation Platform","award":["S202305a12020030"],"award-info":[{"award-number":["S202305a12020030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Postphotoionization has been demonstrated to be an effective method to increase the ionization efficiency of laser desorption ionization. In order to scan samples with compact and hard characteristics from the front side, an ambient pressure laser desorption ionization in combination with a compact postphotoionization assembly (AP-LDI\/PI) in reflection mode was developed. The effects of parameters, including laser energy, frequency, and stepper motor velocity, were carefully investigated. The slices of mouse cerebellum were scanned by AP-LDI\/PI mass spectrometry in both positive and negative ion modes with a spatial resolution of 10 \u03bcm. In addition, the longitudinal sections of Ginkgo biloba were well imaged using AP-LDI\/PI with a spatial resolution of 15 \u03bcm. The spatial distributions of metabolites, including ginkgo acids, choline, glutamate, and ethoxycoumarin, within the longitudinal sections of Ginkgo biloba were distinctly delineated.<\/jats:p>","DOI":"10.1021\/jasms.6c00002","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:06:31Z","timestamp":1784642791000},"page":"1764-1772","source":"Crossref","is-referenced-by-count":0,"title":["Ambient Pressure Laser\nDesorption Ionization\/Postphotoionization\nMass Spectrometry Imaging"],"prefix":"10.1021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-7834","authenticated-orcid":true,"given":"Xiaobo","family":"Yao","sequence":"first","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]},{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liutian","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchun","family":"Lv","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Qi","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minggao","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-3809","authenticated-orcid":true,"given":"Yang","family":"Pan","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230029"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"4","key":"2026080510104979000_cit1","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/mas.20124","article-title":"Imaging mass spectrometry","volume":"26","author":"Mcdonnell","year":"2007","journal-title":"Mass\nSpectrom. Rev."},{"key":"2026080510104979000_cit2","doi-asserted-by":"publisher","first-page":"105378","DOI":"10.1016\/j.envint.2019.105378","article-title":"Evaluation of the splenic\ninjury following exposure of mice to bisphenol S: A mass spectrometry-based\nlipidomics and imaging analysis","volume":"135","author":"Zhao","year":"2020","journal-title":"Environ. Int."},{"key":"2026080510104979000_cit3","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1007\/s00204-016-1905-6","article-title":"Imaging mass\nspectrometry in drug development and toxicology","volume":"91","author":"Karlsson","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"14","key":"2026080510104979000_cit4","doi-asserted-by":"publisher","first-page":"8783","DOI":"10.1021\/acs.analchem.9b00711","article-title":"In situ detection and\nimaging of\nPFOS in mouse kidney by matrix-assisted laser desorption\/ionization\nimaging mass spectrometry","volume":"91","author":"Yang","year":"2019","journal-title":"Anal. Chem."},{"issue":"13","key":"2026080510104979000_cit5","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1073\/pnas.1700677114","article-title":"Diagnosis of prostate cancer by desorption\nelectrospray ionization mass spectrometric imaging of small metabolites\nand lipids","volume":"114","author":"Banerjee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"25","key":"2026080510104979000_cit6","doi-asserted-by":"publisher","first-page":"6347","DOI":"10.1073\/pnas.1803733115","article-title":"Distinguishing malignant from benign\nmicroscopic skin lesions using desorption electrospray ionization\nmass spectrometry imaging","volume":"115","author":"Margulis","year":"2018","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"issue":"42","key":"2026080510104979000_cit7","doi-asserted-by":"publisher","first-page":"15184","DOI":"10.1073\/pnas.1408129111","article-title":"Application\nof desorption electrospray ionization mass spectrometry imaging in\nbreast cancer margin analysis","volume":"111","author":"Calligaris","year":"2014","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"issue":"6","key":"2026080510104979000_cit8","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.7150\/thno.41763","article-title":"Evaluation of the tumor-targeting\nefficiency and intratumor heterogeneity of anticancer drugs using\nquantitative mass spectrometry imaging","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"issue":"9","key":"2026080510104979000_cit9","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.1021\/acs.analchem.9b00026","article-title":"Anticancer drug affects\nmetabolomic profiles in multicellular spheroids: Studies using mass\nspectrometry imaging combined with machine learning","volume":"91","author":"Tian","year":"2019","journal-title":"Anal. Chem."},{"key":"2026080510104979000_cit10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.talanta.2019.04.068","article-title":"Whole-body spatially-resolved metabolomics method for profiling the\nmetabolic differences of epimer drug candidates using ambient mass\nspectrometry imaging","volume":"202","author":"Luo","year":"2019","journal-title":"Talanta"},{"issue":"4","key":"2026080510104979000_cit11","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1111\/tpj.15092","article-title":"Visualizing\nvinca alkaloids in the petal of Catharanthus roseus using functionalized\ntitanium oxide nanowire substrate for surface-assisted laser desorption\/ionization\nimaging mass spectrometry","volume":"105","author":"Dutkiewicz","year":"2021","journal-title":"Plant J."},{"issue":"18","key":"2026080510104979000_cit12","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.1002\/jssc.202100138","article-title":"Mass spectrometry\nimaging for direct visualization of components in plants tissues","volume":"44","author":"Hu","year":"2021","journal-title":"J. Sep. Sci."},{"issue":"43","key":"2026080510104979000_cit13","doi-asserted-by":"publisher","first-page":"15108","DOI":"10.1021\/acs.analchem.2c03329","article-title":"Enhanced coverage\nand sensitivity of imprint DESI mass spectrometry imaging for plant\nleaf metabolites by post-photoionization","volume":"94","author":"Wu","year":"2022","journal-title":"Anal.\nChem."},{"issue":"23","key":"2026080510104979000_cit14","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1021\/ac970888i","article-title":"Molecular imaging of\nbiological samples:\nlocalization of peptides and proteins using MALDI-TOF MS","volume":"69","author":"Caprioli","year":"1997","journal-title":"Anal. Chem."},{"issue":"5695","key":"2026080510104979000_cit15","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1126\/science.1104404","article-title":"Mass spectrometry\nsampling under ambient conditions with desorption electrospray ionization","volume":"306","author":"Taka\u0301ts","year":"2004","journal-title":"Science"},{"issue":"43","key":"2026080510104979000_cit16","doi-asserted-by":"publisher","first-page":"7188","DOI":"10.1002\/anie.200602449","article-title":"Tissue imaging at\natmospheric pressure using desorption electrospray ionization (DESI)\nmass spectrometry","volume":"45","author":"Wiseman","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"issue":"6231","key":"2026080510104979000_cit17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.aaa1051","article-title":"Mass spectrometry imaging with laser-induced\npostionization","volume":"348","author":"Soltwisch","year":"2015","journal-title":"Science"},{"issue":"12","key":"2026080510104979000_cit18","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/j.jasms.2006.08.003","article-title":"Generation and detection of multiply-charged\npeptides and proteins by matrix-assisted laser desorption electrospray\nionization (MALDESI) Fourier transform ion cyclotron resonance mass\nspectrometry","volume":"17","author":"Sampson","year":"2006","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"10","key":"2026080510104979000_cit19","doi-asserted-by":"publisher","first-page":"6616","DOI":"10.1021\/acs.analchem.9b00520","article-title":"Imaging of polar and nonpolar species\nusing compact desorption electrospray ionization\/postphotoionization\nmass spectrometry","volume":"91","author":"Liu","year":"2019","journal-title":"Anal. Chem."},{"key":"2026080510104979000_cit20","doi-asserted-by":"publisher","first-page":"122380","DOI":"10.1016\/j.talanta.2021.122380","article-title":"Cholesterol was identified\nas a biomarker in human melanocytic nevi\nusing DESI and DESI\/PI mass spectrometry imaging","volume":"231","author":"Qi","year":"2021","journal-title":"Talanta"},{"issue":"8","key":"2026080510104979000_cit21","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1007\/s00216-012-5841-x","article-title":"Analysis of\ncolorectal adenocarcinoma tissue by desorption electrospray ionization\nmass spectrometric imaging","volume":"403","author":"Gerbig","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"2026080510104979000_cit22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1039\/B919816D","article-title":"Molecular imaging\nof adrenal gland by desorption electrospray ionization mass spectrometry","volume":"135","author":"Wu","year":"2010","journal-title":"Analyst"},{"issue":"14","key":"2026080510104979000_cit23","doi-asserted-by":"publisher","first-page":"5489","DOI":"10.1021\/acs.analchem.3c05605","article-title":"Development\nof Transmission Ambient Pressure Laser Desorption Ionization\/Postphotoionization\nMass Spectrometry Imaging","volume":"96","author":"Qi","year":"2024","journal-title":"Anal. Chem."},{"issue":"1\u20132","key":"2026080510104979000_cit24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0169-328X(00)00269-2","article-title":"Endogenous\nsynthesis and transport of creatine in the rat brain: An in situ hybridization\nstudy","volume":"86","author":"Braissant","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"5","key":"2026080510104979000_cit25","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/cne.23667","article-title":"Distribution\nof the creatine transporter throughout the human brain reveals a spectrum\nof creatine transporter immunoreactivity","volume":"523","author":"Lowe","year":"2015","journal-title":"J.\nComp. Neurol."},{"key":"2026080510104979000_cit26","doi-asserted-by":"publisher","first-page":"10000","DOI":"10.1038\/srep10000","article-title":"Three-Dimensional Image of Cleavage\nBodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight\nSecondary Ion Mass Spectrometry","volume":"5","author":"Masaki","year":"2015","journal-title":"Sci. Rep."},{"issue":"50","key":"2026080510104979000_cit27","doi-asserted-by":"publisher","first-page":"12103","DOI":"10.1021\/jf503980f","article-title":"High-resolution\ngas chromatography\/mass spectrometry method for characterization and\nquantitative analysis of ginkgolic acids in Ginkgo biloba plants,\nextracts, and dietary supplements","volume":"62","author":"Wang","year":"2014","journal-title":"J. Agric.\nFood Chem."},{"issue":"11","key":"2026080510104979000_cit28","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1111\/pce.13395","article-title":"Interrogation of spatial metabolome of Ginkgo biloba\nwith high-resolution matrix-assisted laser desorption\/ionization and\nlaser desorption\/ionization mass spectrometry imaging","volume":"41","author":"Li","year":"2018","journal-title":"Plant, Cell Environ."},{"issue":"6","key":"2026080510104979000_cit29","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/j.1365-3040.2005.01329.x","article-title":"Differential accumulation\nof maysin and rhamnosylisoorientin\nin leaves of high-altitude landraces of maize after UV-B exposure","volume":"28","author":"Casati","year":"2005","journal-title":"Plant, Cell Environ."},{"issue":"3","key":"2026080510104979000_cit30","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1603\/0022-0493-96.3.909","article-title":"Effect of\nmaysin on wild-type, deltamethrin-resistant,\nand Bt-resistant Helicoverpa armigera (Lepidoptera: Noctuidae)","volume":"96","author":"Rector","year":"2003","journal-title":"J. Econ. Entomol."}],"container-title":["Journal of the American\nSociety for Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.6c00002","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/8\/1764\/66086064\/jasms.6c00002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/8\/1764\/66086064\/jasms.6c00002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:25:59Z","timestamp":1785939959000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jamsef\/article\/37\/8\/1764\/5224614\/Ambient-Pressure-Laser-Desorption-Ionization"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,21]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1021\/jasms.6c00002","relation":{},"ISSN":["1044-0305","1879-1123"],"issn-type":[{"value":"1044-0305","type":"print"},{"value":"1879-1123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}