{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:59:26Z","timestamp":1785941966940,"version":"3.56.0"},"reference-count":15,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Drug-induced phospholipidosis is a common side effect of the pharmacological treatment. Although mostly reversible, it can lead to deleterious consequences, including inflammation and fibrosis. While it can be readily detected in tissue biopsies or cell cultures, biomarkers that can be measured noninvasively remain scarce. We used a panel of four compounds known to induce phospholipidosis to investigate three primary target tissues as potential new biomarkers. Using mass spectrometry imaging, followed by analysis with prediction models and feature-wise statistical analysis, we identified over 150 mass\/charge features correlated with DIPL in general or in specific tissues, many of which yielded database hits in the LipidMaps DB in molecule classes linked to DIPL before. Our data set provides a foundation for annotating reliable biomarkers in blood and urine.<\/jats:p>","DOI":"10.1021\/jasms.6c00010","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:14:04Z","timestamp":1782566044000},"page":"1783-1791","source":"Crossref","is-referenced-by-count":0,"title":["Screen for Tissue-Specific\nMarkers of Drug-Induced\nPhospholipidosis Using Mass Spectrometry Imaging"],"prefix":"10.1021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1675-7863","authenticated-orcid":true,"given":"Christoph","family":"Hoffmann","sequence":"first","affiliation":[{"name":"University Hospital Tu\u0308bingen , , ,","place":["Tu\u0308bingen, Germany, 72076"]},{"name":"University of Tu\u0308bingen , , ,","place":["Tu\u0308bingen, Germany, 72074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Lekic\u0301","sequence":"additional","affiliation":[{"name":"Department of Information Technology EDP , Central Data Science, Boehringer Ingelheim GmbH , ,","place":["Biberach an der Ri\u00df, Germany, 88397"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Global Nonclinical Safety & DMPK , Boehringer Ingelheim GmbH und Co KG , ,","place":["Biberach an der Riss, Germany, 88400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Claassen","sequence":"additional","affiliation":[{"name":"University Hospital Tu\u0308bingen , , ,","place":["Tu\u0308bingen, Germany, 72076"]},{"name":"University of Tu\u0308bingen , , ,","place":["Tu\u0308bingen, Germany, 72074"]},{"name":"M3 Research Center, University Hospital Tu\u0308bingen , ,","place":["Tu\u0308bingen, Germany, 72076"]},{"name":"University of Tu\u0308bingen , , ,","place":["Tu\u0308bingen, Germany, 72074"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"issue":"4","key":"2026080510100887800_cit1","first-page":"454","article-title":"Chloroquine (SN-7618)-Pathologic Changes observed in\nRats which for Two Years had been fed various Proportions","volume":"45","author":"Nelson","year":"1948","journal-title":"Arch. 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Pharmacol."},{"key":"2026080510100887800_cit8","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1194\/jlr.M073395","article-title":"Alterations\nin endo-lysosomal function induce similar hepatic lipid profiles in\nrodent models of drug-induced phospholipidosis and Sandhoff disease","volume":"58","author":"Lecommandeur","year":"2017","journal-title":"J. Lipid Res."},{"key":"2026080510100887800_cit9","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1021\/ac970888i","article-title":"Molecular imaging of biological samples:\nlocalization of peptides and proteins using MALDI-TOF MS","volume":"69","author":"Caprioli","year":"1997","journal-title":"Anal. Chem."},{"key":"2026080510100887800_cit10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijms.2006.10.007","article-title":"Compound and\nmetabolite distribution\nmeasured by MALDI mass spectrometric imaging in whole-body tissue\nsections","volume":"260","author":"Stoeckli","year":"2007","journal-title":"Int. J. Mass Spectrom."},{"key":"2026080510100887800_cit11","doi-asserted-by":"publisher","first-page":"D1677","DOI":"10.1093\/nar\/gkad896","article-title":"LIPID\nMAPS: update to\ndatabases and tools for the lipidomics community","volume":"52","author":"Conroy","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"2026080510100887800_cit12","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1093\/oxfordjournals.jbchem.a135438","article-title":"Reduction\nof acid sphingomyelinase\nactivity in human fibroblasts induced by AY-9944 and other cationic\namphiphilic drugs","volume":"98","author":"Yoshida","year":"1985","journal-title":"J. Biochem."},{"key":"2026080510100887800_cit13","doi-asserted-by":"publisher","first-page":"124","DOI":"10.4132\/jptm.2025.12.10","article-title":"Drug-induced phospholipidosis\nof the kidney suspected to be caused by atomoxetine","volume":"60","author":"Choi","year":"2026","journal-title":"J Pathol Transl Med"},{"key":"2026080510100887800_cit14","first-page":"1025","volume-title":"Lysosomal Dynamics\nInduced by Poly-D-Glutamic Acid in Kidney Proximal Tubular Cells","author":"Kishore","year":"1996"},{"key":"2026080510100887800_cit15","doi-asserted-by":"publisher","first-page":"100574","DOI":"10.1016\/j.jlr.2024.100574","article-title":"The role\nof lysosomal phospholipase A2 in the catabolism of bis (monoacylglycerol)\nphosphate and association with phospholipidosis","volume":"65","author":"Abe","year":"2024","journal-title":"J. Lipid Res."}],"container-title":["Journal of the American\nSociety for Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.6c00010","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/8\/1783\/65263378\/jasms.6c00010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/8\/1783\/65263378\/jasms.6c00010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:21:59Z","timestamp":1785939719000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jamsef\/article\/37\/8\/1783\/5169896\/Screen-for-Tissue-Specific-Markers-of-Drug-Induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,6,27]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1021\/jasms.6c00010","relation":{},"ISSN":["1044-0305","1879-1123"],"issn-type":[{"value":"1044-0305","type":"print"},{"value":"1879-1123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,27]]}}}