{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:59:21Z","timestamp":1791385161337,"version":"4.3.3"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP240559"],"award-info":[{"award-number":["RP240559"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MD Anderson?s Bridge Funding Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thermoembolization (TE) is a new, minimally invasive approach that could improve outcomes in select patients with hepatocellular carcinoma. However, little is known about the effects of this procedure at the molecular level. To gain greater insight into the molecular effects of TE, we performed a pilot study of transarterial TE with 2-propylpentanoyl chloride in a swine model with 3 animals. Liver tissues were harvested 7 days after the procedure, and formalin-fixed specimens were subjected to serial mass spectrometry imaging (MSI) analyses of metabolites, glycans, and tryptic peptides. We observed striking differences in spatial distributions for multiple features in the TE-treated and untreated areas. Our results show that TE is highly effective in causing coagulative necrosis in the target tissue and based on the data we propose that TE may cause localized chemical alterations in tissues. Our study further demonstrates that MSI is a powerful tool that can provide fundamentally new insights into the potential of using TE or other image-guided in vivo chemistry techniques to alter local biology.<\/jats:p>","DOI":"10.1021\/jasms.6c00092","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:01:06Z","timestamp":1788328866000},"page":"2310-2320","source":"Crossref","is-referenced-by-count":0,"title":["Serial Analyses with Mass Spectrometry Imaging Reveal\nChemical and Metabolic Alterations in Liver Tissue Following Thermoembolization"],"prefix":"10.1021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-9862","authenticated-orcid":true,"given":"Erik N. 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Liver Dis."},{"issue":"3","key":"2026100710070000200_cit6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jvir.2018.11.037","article-title":"Association\nof Complete\nRadiologic and Pathologic Response following Locoregional Therapy\nbefore Liver Transplantation with Long-Term Outcomes of Hepatocellular\nCarcinoma: A Retrospective Study","volume":"30","author":"Habibollahi","year":"2019","journal-title":"J. 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Roentgenol."},{"issue":"6","key":"2026100710070000200_cit9","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jvir.2025.02.016","article-title":"Comparative Radiologic Response Assessment\nafter Transarterial Chemoembolization, Percutaneous Ablation, and\nMultimodal Treatment: Radiologic-Pathologic Correlation in 81 Tumors","volume":"36","author":"Badar","year":"2025","journal-title":"J. Vasc Interv Radiol"},{"issue":"7","key":"2026100710070000200_cit10","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.jvir.2018.12.736","article-title":"Bridging Hepatocellular\nCarcinoma to Transplant:\nTransarterial Chemoembolization Response, Tumor Biology, and Recurrence\nafter Transplantation in a 12-Year Transplant Cohort","volume":"30","author":"Sandow","year":"2019","journal-title":"J. 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Mass Spectrom."},{"issue":"39","key":"2026100710070000200_cit30","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone Deacetylase\nIs a Direct Target of Valproic\nAcid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"2026100710070000200_cit31","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1124\/mol.65.3.520","article-title":"Valproic acid inhibits\nangiogenesis in vitro and in vivo","volume":"65","author":"Michaelis","year":"2004","journal-title":"Mol. 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J.\nPharm. Res."},{"issue":"14","key":"2026100710070000200_cit34","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.3390\/cancers13143409","article-title":"Valproic Acid and Breast Cancer:\nState of the Art in\n2021","volume":"13","author":"Wawruszak","year":"2021","journal-title":"Cancers"},{"key":"2026100710070000200_cit35","doi-asserted-by":"publisher","first-page":"122540","DOI":"10.1016\/j.lfs.2024.122540","article-title":"Molecular mechanisms\nof TACE refractoriness: Directions for improvement of the TACE procedure","volume":"342","author":"Li","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"2026100710070000200_cit36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3109\/02656736.2012.756124","article-title":"Dual mode single\nagent thermochemical ablation by simultaneous\nrelease of heat energy and acid: hydrolysis of electrophiles","volume":"29","author":"Cressman","year":"2013","journal-title":"Int. J. 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