{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:15:11Z","timestamp":1788455711842,"version":"build-2803163510"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"Stanford Propel Postdoctoral Scholars","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Radiation therapy (RT) is a central component of cancer treatment, including breast cancer, and primarily damages DNA in cancer cells, causing cell death. However, secondary effects of RT that may influence tumor and normal tissue both within and beyond the site of irradiation are not well characterized, particularly at the level of the circulating blood proteome. In this study, isotopic acrylamide labeling of proteins and high-resolution LC\u2013MS\/MS were used to analyze plasma proteins from breast cancer patients before, during, and after RT. Clustering analysis was used to group proteins according to how their levels changed over time. A total of 31 proteins were identified whose levels were altered during RT but returned to baseline following the conclusion of treatment, representing key parts of the immune response to RT. Another set of 31 proteins related to the extracellular matrix and other functions was altered during RT and remained altered after RT. Specific time points were also examined, and acute changes were identified at the start of RT in the levels of 63 proteins involved in coagulation, cell\u2013cell adhesion, and carbohydrate metabolism. After the end of RT, the circulating levels of 23 extracellular matrix proteins remained altered. These LC\u2013MS\/MS findings were validated orthogonally by ELISAs of three proteins in a larger group of breast cancer patients undergoing RT. Overall, in this study, temporal changes in the circulating blood proteome of breast cancer patients undergoing RT were characterized, and these altered protein levels were linked to potential alterations in biological pathways.<\/jats:p>","DOI":"10.1021\/jasms.6c00168","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:12:10Z","timestamp":1785129130000},"page":"2141-2154","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying Protein\nTemporal Changes with Mass Spectrometry\nin Plasma Samples from Breast Cancer Patients Undergoing Radiotherapy"],"prefix":"10.1021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-8569","authenticated-orcid":true,"given":"Kathryn L.","family":"Kapp","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.","family":"Going","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J.","family":"Garcia-Marques","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Leow","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6631-481X","authenticated-orcid":true,"given":"Alisha","family":"Maltos","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vilalta","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Rafat","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Jane","family":"Chen","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Mallick","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Horst","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Graves","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3119-873X","authenticated-orcid":true,"given":"Sharon J.","family":"Pitteri","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , , , ,","place":["Palo Alto, California, United States, 94304"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"issue":"16","key":"2026090311504737900_cit1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year\nfollow-up of a randomized trial comparing total mastectomy, lumpectomy,\nand lumpectomy plus irradiation for the treatment of invasive breast\ncancer","volume":"347","author":"Fisher","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2026090311504737900_cit2","first-page":"187","article-title":"Breast Cancer","volume-title":"Clinical Oncology","author":"Langmuir","year":"1993","edition":"7"},{"key":"2026090311504737900_cit3","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1002\/cncr.26081","article-title":"Impact of evidence-based clinical\nguidelines on the adoption of postmastectomy radiation in older women","volume":"117","author":"Shirvani","year":"2011","journal-title":"Cancer"},{"key":"2026090311504737900_cit4","volume-title":"Radiobiology for the\nRadiologist","author":"Hall","year":"2006"},{"issue":"4","key":"2026090311504737900_cit5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1667\/RR1931.1","article-title":"Links between innate\nimmunity and normal tissue radiobiology","volume":"173","author":"Schaue","year":"2010","journal-title":"Radiat.\nRes."},{"issue":"2","key":"2026090311504737900_cit6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.ijrobp.2019.10.028","article-title":"Circulating microRNAs as Biomarkers\nof Radiation Exposure: A Systematic Review and Meta-Analysis","volume":"106","author":"Malachowska","year":"2020","journal-title":"Int. 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Inflamm.\nRes."},{"issue":"1","key":"2026090311504737900_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/prca.202400010","article-title":"TMT-Based\nQuantitative Proteomic Profiling of Human Esophageal Cancer Cells\nReveals the Potential Mechanism and Potential Therapeutic Targets\nAssociated With Radioresistance","volume":"19","author":"Gao","year":"2025","journal-title":"Proteonomics\nClin. Appl."},{"issue":"3","key":"2026090311504737900_cit40","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1111\/cas.13946","article-title":"REV7 confers\nradioresistance of esophagus squamous cell carcinoma by recruiting\nPRDX2","volume":"110","author":"Gu","year":"2019","journal-title":"Cancer Sci."},{"issue":"14","key":"2026090311504737900_cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34630","article-title":"Exploring\nthe key genes associated with breast cancer radiotherapy sensitivity\nbased on the stromal-immune score and analysis of the WGCNA and ceRNA\nnetwork","volume":"10","author":"Sun","year":"2024","journal-title":"Heliyon"},{"key":"2026090311504737900_cit42","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2023.14","article-title":"Inflammasomes in breast cancer: the\nignition spark\nof progression and resistance?","volume":"25","author":"Elgohary","year":"2023","journal-title":"Expert Rev.\nMol. Med."},{"key":"2026090311504737900_cit43","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1515\/med-2017-0028","article-title":"Carnitine and Adiponectin\nLevels in Breast Cancer after Radiotherapy","volume":"12","author":"Ozmen","year":"2017","journal-title":"Open Med."},{"issue":"1","key":"2026090311504737900_cit44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12885-018-4011-8","article-title":"Screening\nfor immune-potentiating\nantigens from hepatocellular carcinoma patients after radiofrequency\nablation by serum proteomic analysis","volume":"18","author":"Shen","year":"2018","journal-title":"BMC Cancer"},{"issue":"2","key":"2026090311504737900_cit45","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/proteomes13020025","article-title":"Deciphering Radiotherapy\nResistance: A Proteomic Perspective","volume":"13","author":"Perico","year":"2025","journal-title":"Proteomes"},{"issue":"12","key":"2026090311504737900_cit46","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling\nthe extracellular matrix\nin development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell\nBiol."},{"issue":"1","key":"2026090311504737900_cit47","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1186\/s12885-025-15071-2","article-title":"Integrative\nanalysis identifies radiotherapy\nresistance-associated CAF subtypes shaping the tumor immune landscape\nin breast cancer","volume":"25","author":"Li","year":"2025","journal-title":"BMC Cancer"},{"issue":"1","key":"2026090311504737900_cit48","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41419-026-08416-7","article-title":"Targeting\nENO1 reprograms macrophage polarization to trigger antitumor immunity\nand improves the therapeutic effect of radiotherapy","volume":"17","author":"Lin","year":"2026","journal-title":"Cell Death Dis."},{"key":"2026090311504737900_cit49","doi-asserted-by":"publisher","first-page":"626058","DOI":"10.3389\/fonc.2021.626058","article-title":"Pre- and Postoperative\nCirculating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine\nTreatment and Breast Cancer Recurrence: A Nested Case-Control Study","volume":"11","author":"Rosendahl","year":"2021","journal-title":"Front. 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Oncol., Biol., Phys."},{"issue":"D1","key":"2026090311504737900_cit51","doi-asserted-by":"publisher","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database\nat 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of the American\nSociety for Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.6c00168","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/9\/2141\/66254781\/jasms.6c00168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/9\/2141\/66254781\/jasms.6c00168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:21:00Z","timestamp":1788452460000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jamsef\/article\/37\/9\/2141\/5232316\/Quantifying-Protein-Temporal-Changes-with-Mass"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,7,25]]},"published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1021\/jasms.6c00168","relation":{},"ISSN":["1044-0305","1879-1123"],"issn-type":[{"value":"1044-0305","type":"print"},{"value":"1879-1123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]}}}