{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:57:47Z","timestamp":1791385067596,"version":"4.3.3"},"reference-count":111,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001790","name":"Ara Parseghian Medical Research Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100001790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Dana?s Angel?s Research Trust","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Support Of Accelerated Research for Niemann-Pick C","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"UIC Department of Chemistry, College of Liberal Arts and Sciences","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Niemann-Pick disease type C (NPC) is a lysosomal storage disorder characterized by the accumulation of unesterified cholesterol and glycosphingolipids in the late endosomal\/lysosomal system, resulting in region-specific neurodegeneration. While the mechanism through which defective NPC1 protein and thus altered cholesterol transport engenders neurodegeneration is unknown, selective reintroduction of the NPC1 gene in different cell types in the mouse brain can alleviate disease symptoms, suggesting that neuronal and glial cells may play distinct roles in disease mechanisms. Here, in an in vitro NPC model, we evaluate cell-specific changes in the proteome upon treatment with a small-molecule cholesterol-trafficking inhibitor, U18666A, which inhibits NPC1 function across three immortalized cell lines in the central nervous system (CNS): mouse hippocampal neuronal cells (HT-22), mouse microglial cells (SIM-A9), and human hybridized oligodendrocytes (MO3.13). Using nanoliquid chromatography\u2013mass spectrometry (LC\u2013MS) techniques, we observe 21 common proteins upregulated in all U18666A-treated cells. We also note that markers of activated microglia were significantly altered in SIM-A9 microglial cells, whereas cytoskeletal and membrane-related proteins were elevated in MO3.13. In HT-22 hippocampal neuronal cells, we identify protein changes associated with altered glucose metabolism and postulate that ATP-citrate lyase (ACLY), a protein central to multiple biological pathways, might play a role in responding to aberrant cholesterol trafficking and metabolism in NPC.<\/jats:p>","DOI":"10.1021\/jasms.6c00184","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:21:07Z","timestamp":1788351667000},"page":"2396-2409","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Signatures\nin Neuronal and Glial Cell Models\nof Niemann-Pick Disease Type C"],"prefix":"10.1021","volume":"37","author":[{"given":"Olivia C.","family":"Wagner","sequence":"first","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu T. A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Javanshad","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koralege C.","family":"Pathmasiri","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Boktor","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Davy","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5917-5380","authenticated-orcid":true,"given":"Wenping","family":"Li","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-3361","authenticated-orcid":true,"given":"Stephanie M.","family":"Cologna","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago , , , ,","place":["Chicago, Illinois, United States, 60607"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"issue":"1","key":"2026100710071196400_cit1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-018-0025-4","article-title":"Lysosomal\nstorage diseases","volume":"4","author":"Platt","year":"2018","journal-title":"Nat. Rev. Dis Primers"},{"key":"2026100710071196400_cit2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/1750-1172-8-166","article-title":"Niemann-Pick disease\ntype C symptomatology: an expert-based clinical description","volume":"8","author":"Mengel","year":"2013","journal-title":"Orphanet J. Rare Dis"},{"issue":"1","key":"2026100710071196400_cit3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10545-013-9626-y","article-title":"Niemann-Pick type\nC Suspicion Index\ntool: analyses by age and association of manifestations","volume":"37","author":"Wraith","year":"2014","journal-title":"J. Inherit Metab Dis"},{"issue":"2","key":"2026100710071196400_cit4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF00227765","article-title":"Cerebellar\ndegeneration\nin the Niemann-Pick type C mouse","volume":"85","author":"Higashi","year":"1993","journal-title":"Acta Neuropathol."},{"issue":"5500","key":"2026100710071196400_cit5","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1126\/science.290.5500.2298","article-title":"Identification of HE1\nas the second gene of Niemann-Pick C disease","volume":"290","author":"Naureckiene","year":"2000","journal-title":"Science"},{"key":"2026100710071196400_cit6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1750-1172-5-16","article-title":"Niemann-Pick\ndisease type C","volume":"5","author":"Vanier","year":"2010","journal-title":"Orphanet J. Rare Dis"},{"issue":"4","key":"2026100710071196400_cit7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann-Pick disease type C","volume":"64","author":"Vanier","year":"2003","journal-title":"Clin. Genet."},{"issue":"12","key":"2026100710071196400_cit8","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1093\/hmg\/ddy112","article-title":"Microglia activation\nin Niemann-Pick disease, type C1 is amendable to therapeutic intervention","volume":"27","author":"Cougnoux","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"2026100710071196400_cit9","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1038\/s41467-021-21428-5","article-title":"Loss of NPC1 enhances phagocytic uptake and impairs\nlipid trafficking in microglia","volume":"12","author":"Colombo","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"2026100710071196400_cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003462","article-title":"Npc1 acting\nin neurons and glia is essential for the\nformation and maintenance of CNS myelin","volume":"9","author":"Yu","year":"2013","journal-title":"PLoS\nGenet."},{"key":"2026100710071196400_cit11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12177","article-title":"Identification of NPC1 as the target\nof U18666A, an inhibitor of lysosomal cholesterol export and Ebola\ninfection","volume":"4","author":"Lu","year":"2015","journal-title":"eLife"},{"issue":"20","key":"2026100710071196400_cit12","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1016\/0006-2952(80)90006-4","article-title":"Concentration-dependent\neffects of AY-9944 and U18666A on sterol synthesis in brain. Variable\nsensitivities of metabolic steps","volume":"29","author":"Cenedella","year":"1980","journal-title":"Biochem. Pharmacol."},{"issue":"20","key":"2026100710071196400_cit13","doi-asserted-by":"publisher","first-page":"11796","DOI":"10.1016\/S0021-9258(18)80136-3","article-title":"The intracellular\ntransport of low density lipoprotein-derived\ncholesterol is inhibited in Chinese hamster ovary cells cultured with\n3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one","volume":"264","author":"Liscum","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"9","key":"2026100710071196400_cit14","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/S0022-2275(20)40539-5","article-title":"Intracellular cholesterol transport","volume":"33","author":"Liscum","year":"1992","journal-title":"J. Lipid Res."},{"issue":"7","key":"2026100710071196400_cit15","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1074\/jbc.273.7.4266","article-title":"Evidence for\na cholesterol\ntransport pathway from lysosomes to endoplasmic reticulum that is\nindependent of the plasma membrane","volume":"273","author":"Underwood","year":"1998","journal-title":"J. Biol.\nChem."},{"issue":"7","key":"2026100710071196400_cit16","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/S0022-2275(20)39138-0","article-title":"Quantitative analysis\nof hydrophobic amine inhibition of intracellular cholesterol transport","volume":"37","author":"Underwood","year":"1996","journal-title":"J. Lipid Res."},{"issue":"45","key":"2026100710071196400_cit17","doi-asserted-by":"publisher","first-page":"43271","DOI":"10.1074\/jbc.M207532200","article-title":"ABCA1-mediated cholesterol efflux\nis defective in free cholesterol-loaded\nmacrophages. Mechanism involves enhanced ABCA1 degradation in a process\nrequiring full NPC1 activity","volume":"277","author":"Feng","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"27","key":"2026100710071196400_cit18","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1074\/jbc.272.27.17018","article-title":"The fate of\ncholesterol exiting lysosomes","volume":"272","author":"Lange","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"30","key":"2026100710071196400_cit19","doi-asserted-by":"publisher","first-page":"18915","DOI":"10.1074\/jbc.273.30.18915","article-title":"Circulation\nof cholesterol between lysosomes and the\nplasma membrane","volume":"273","author":"Lange","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6","key":"2026100710071196400_cit20","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1007\/s12035-023-03798-7","article-title":"Potential\nUse of the Cholesterol Transfer Inhibitor U18666A as a Potent Research\nTool for the Study of Cholesterol Mechanisms in Neurodegenerative\nDisorders","volume":"61","author":"Yasamineh","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"2026100710071196400_cit21","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1021\/acs.jproteome.3c00788","article-title":"Endogenous Protein-Protein\nInteraction\nNetwork of the NPC Cholesterol Transporter 1 in the Cerebral Cortex","volume":"23","author":"Javanshad","year":"2024","journal-title":"J. Proteome Res."},{"issue":"4","key":"2026100710071196400_cit22","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1194\/jlr.M056986","article-title":"The terminal enzymes\nof cholesterol synthesis, DHCR24 and DHCR7, interact physically and\nfunctionally","volume":"56","author":"Luu","year":"2015","journal-title":"J. Lipid Res."},{"issue":"4670","key":"2026100710071196400_cit23","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1038\/1831259a0","article-title":"Antagonism of chlorine and inositol","volume":"183","author":"Agranoff","year":"1959","journal-title":"Nature"},{"issue":"24","key":"2026100710071196400_cit24","doi-asserted-by":"publisher","first-page":"13172","DOI":"10.1073\/pnas.240454797","article-title":"Isoprenoid biosynthesis:\nthe evolution of two ancient and distinct pathways across genomes","volume":"97","author":"Lange","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"2026100710071196400_cit25","doi-asserted-by":"publisher","first-page":"4893","DOI":"10.1007\/s00216-015-8732-0","article-title":"Sample\npreparation strategies for\nimproving the identification of membrane proteins by mass spectrometry","volume":"407","author":"Alfonso-Garrido","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"issue":"5","key":"2026100710071196400_cit26","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/neup.12204","article-title":"Isopentenyl\ndiphosphate isomerase, a cholesterol synthesizing\nenzyme, is localized in Lewy bodies","volume":"35","author":"Nakamura","year":"2015","journal-title":"Neuropathology"},{"issue":"7","key":"2026100710071196400_cit27","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1128\/MCB.01140-13","article-title":"The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase\nand affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the\ncholesterol synthesis pathway","volume":"34","author":"Zelcer","year":"2014","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"2026100710071196400_cit28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.cmet.2011.01.015","article-title":"Cholesterol-dependent\ndegradation of squalene monooxygenase, a control point in cholesterol\nsynthesis beyond HMG-CoA reductase","volume":"13","author":"Gill","year":"2011","journal-title":"Cell Metab."},{"issue":"49","key":"2026100710071196400_cit29","doi-asserted-by":"publisher","first-page":"19959","DOI":"10.1074\/jbc.M117.794230","article-title":"A conserved\ndegron containing an amphipathic helix regulates the cholesterol-mediated\nturnover of human squalene monooxygenase, a rate-limiting enzyme in\ncholesterol synthesis","volume":"292","author":"Chua","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"12","key":"2026100710071196400_cit30","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1016\/S0022-2275(20)32101-5","article-title":"Regulation of endoplasmic reticulum\ncholesterol by plasma membrane cholesterol","volume":"40","author":"Lange","year":"1999","journal-title":"J. Lipid Res."},{"issue":"10","key":"2026100710071196400_cit31","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/nn1750","article-title":"Bergmann glia expression\nof polyglutamine-expanded\nataxin-7 produces neurodegeneration by impairing glutamate transport","volume":"9","author":"Custer","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"5","key":"2026100710071196400_cit32","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes\nexpressing ALS-linked mutated SOD1 release factors selectively toxic\nto motor neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"13","key":"2026100710071196400_cit33","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1002\/jnr.21730","article-title":"Astrocyte-only Npc1\nreduces neuronal cholesterol and\ntriples life span of Npc1\u2013\/\u2013 mice","volume":"86","author":"Zhang","year":"2008","journal-title":"J. Neurosci. Res."},{"issue":"10","key":"2026100710071196400_cit34","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","article-title":"Microglia Immune and non-immune functions","volume":"54","author":"Borst","year":"2021","journal-title":"Immunity"},{"key":"2026100710071196400_cit35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jneumeth.2014.05.021","article-title":"A novel cell line\nfrom spontaneously\nimmortalized murine microglia","volume":"233","author":"Nagamoto-Combs","year":"2014","journal-title":"J. Neurosci.\nMethods"},{"key":"2026100710071196400_cit36","doi-asserted-by":"publisher","first-page":"102052","DOI":"10.1016\/j.redox.2021.102052","article-title":"Acid ceramidase\nimproves mitochondrial function and oxidative stress in Niemann-Pick\ntype C disease by repressing STARD1 expression and mitochondrial cholesterol\naccumulation","volume":"45","author":"Torres","year":"2021","journal-title":"Redox Biol."},{"issue":"11","key":"2026100710071196400_cit37","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1002\/humu.23860","article-title":"Mutation update: Review of TPP1 gene\nvariants associated with neuronal ceroid lipofuscinosis CLN2 disease","volume":"40","author":"Gardner","year":"2019","journal-title":"Hum. Mutat."},{"issue":"27","key":"2026100710071196400_cit38","doi-asserted-by":"publisher","first-page":"20423","DOI":"10.1074\/jbc.R110.134452","article-title":"Common and uncommon pathogenic cascades\nin lysosomal storage diseases","volume":"285","author":"Vitner","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"2026100710071196400_cit39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10545-013-9610-6","article-title":"Human and mouse\nneuroinflammation markers in Niemann-Pick\ndisease, type C1","volume":"37","author":"Cologna","year":"2014","journal-title":"J. Inherited Metab. Dis."},{"issue":"776","key":"2026100710071196400_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adl4616","article-title":"Myeloid\ncell\u2013specific loss of NPC1 in mice recapitulates\nmicrogliosis and neurodegeneration in patients with Niemann-Pick type\nC disease","volume":"16","author":"Dinkel","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"2026100710071196400_cit41","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S0014-4886(03)00345-5","article-title":"Postnatal development\nof inflammation in a murine model of Niemann\u2013Pick type C disease:\nimmunohistochemical observations of microglia and astroglia","volume":"184","author":"Baudry","year":"2003","journal-title":"Exp. Neurol."},{"key":"2026100710071196400_cit42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048273","volume-title":"Genomic Expression Analyses Reveal Lysosomal,\nInnate Immunity Proteins, as Disease Correlates in Murine Models of\na Lysosomal Storage Disorder","author":"Alam","year":"2012"},{"issue":"3","key":"2026100710071196400_cit43","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.nbd.2011.12.027","article-title":"Early glial\nactivation, synaptic changes and axonal pathology in the thalamocortical\nsystem of Niemann\u2013Pick type C1 mice","volume":"45","author":"Pressey","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"15","key":"2026100710071196400_cit44","doi-asserted-by":"publisher","first-page":"5368","DOI":"10.3390\/ijms21155368","article-title":"Single cell transcriptome analysis\nof niemann\u2013pick disease, type c1 cerebella","volume":"21","author":"Cougnoux","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"2026100710071196400_cit45","doi-asserted-by":"publisher","first-page":"167478","DOI":"10.1016\/j.bbadis.2024.167478","article-title":"Npc1 deficiency impairs microglia\nfunction via TREM2-mTOR signaling in Niemann-Pick disease type C","volume":"1870","author":"Qiao","year":"2024","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"1","key":"2026100710071196400_cit46","doi-asserted-by":"publisher","first-page":"8638","DOI":"10.1038\/s41467-024-52874-6","article-title":"NPC1 links cholesterol\ntrafficking to microglial morphology via the\ngastrosome","volume":"15","author":"Zareba","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"2026100710071196400_cit47","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.devcel.2019.02.014","article-title":"Clearance by Microglia\nDepends on\nPackaging of Phagosomes into a Unique Cellular Compartment","volume":"49","author":"Villani","year":"2019","journal-title":"Dev. Cell"},{"issue":"9","key":"2026100710071196400_cit48","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/s41423-020-0461-4","article-title":"Wdfy1 deficiency impairs\nTlr3-mediated\nimmune responses in vivo","volume":"17","author":"Yang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"2026100710071196400_cit49","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/neu.480260212","article-title":"A human\nglial hybrid cell line differentially expressing genes subserving\noligodendrocyte and astrocyte phenotype","volume":"26","author":"McLaurin","year":"1995","journal-title":"J.\nNeurobiol."},{"issue":"1","key":"2026100710071196400_cit50","doi-asserted-by":"publisher","DOI":"10.13188\/2332-3469.1000035","article-title":"Diverse Biological\nFunctions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate\nMyelination in Developing Brain but Stimulate Demyelination during\nPathogenesis of Multiple Sclerosis","volume":"5","author":"Dasgupta","year":"2017","journal-title":"J. Neurol\nPsychol"},{"issue":"5","key":"2026100710071196400_cit51","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1089\/neu.2007.0436","article-title":"Molecular mechanisms of Fas-mediated\ncell death in\noligodendrocytes","volume":"25","author":"Austin","year":"2008","journal-title":"J. Neurotrauma"},{"key":"2026100710071196400_cit52","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3389\/fncel.2015.00180","article-title":"MK-801 treatment\naffects glycolysis\nin oligodendrocytes more than in astrocytes and neuronal cells: insights\nfor schizophrenia","volume":"09","author":"Guest","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"2026100710071196400_cit53","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.brainres.2013.02.024","article-title":"Role of endogenous\npsychosine accumulation in oligodendrocyte differentiation and survival:\nimplication for Krabbe disease","volume":"1508","author":"Won","year":"2013","journal-title":"Brain Res."},{"issue":"1","key":"2026100710071196400_cit54","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1152\/physrev.1968.48.1.197","article-title":"Glial cells\nand the central myelin sheath","volume":"48","author":"Bunge","year":"1968","journal-title":"Physiol. Rev."},{"issue":"4","key":"2026100710071196400_cit55","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0022-2275(20)39619-X","article-title":"Lipid composition\nof the normal human brain: gray matter,\nwhite matter, and myelin","volume":"6","author":"O\u2019Brien","year":"1965","journal-title":"J. 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