{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:57:51Z","timestamp":1791385071046,"version":"4.3.3"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["10108639"],"award-info":[{"award-number":["10108639"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["TED2021-132635B-I00"],"award-info":[{"award-number":["TED2021-132635B-I00"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007512","name":"Universitat Rovira i Virgili","doi-asserted-by":"publisher","award":["PRE2019-089374"],"award-info":[{"award-number":["PRE2019-089374"]}],"id":[{"id":"10.13039\/501100007512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PID2022-136226OB-I00"],"award-info":[{"award-number":["PID2022-136226OB-I00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Ministerio de Ciencia e Innovaci?n","doi-asserted-by":"publisher","award":["CPP2022-010039"],"award-info":[{"award-number":["CPP2022-010039"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Ministerio de Ciencia e Innovaci?n","doi-asserted-by":"publisher","award":["PID2022-136226OB-I00"],"award-info":[{"award-number":["PID2022-136226OB-I00"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Matrix-Assisted Laser Desorption\/Ionization Mass Spectrometry Imaging (MALDI-MSI) enables spatially resolved molecular analysis of biological tissues. However, imaging low-molecular-weight metabolites remains challenging because conventional organic matrices generate intense background signals in the low m\/z region. Ionic matrices can reduce matrix-related interferences, improve spectral reproducibility, and enhance sensitivity. However, their application in MALDI-MSI has remained limited, largely due to the need for additional matrix preparation and the challenging wet deposition of viscous ionic liquid matrices, and has mainly focused on lipid imaging above m\/z 500. Here, we present a novel approach combining ionic solid matrices (ISMs) with low-temperature thermal evaporation (LTE) to enhance MALDI-MSI performance for small metabolites. ISMs based on \u03b1-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) provided superior sensitivity and reduced matrix background. In particular, CHCA + N,N-diethylaniline enabled the detection and annotation of 69 metabolites with m\/z &amp;lt; 500 in mouse brain tissue at 20 \u03bcm spatial resolution. When applied to mouse pancreas, this ISM allowed the first specific localization of melatonin and 3-iodotyrosine within the islets of Langerhans, opening new avenues for spatial metabolomics in endocrine research.<\/jats:p>","DOI":"10.1021\/jasms.6c00219","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:57:51Z","timestamp":1788465471000},"page":"2463-2471","source":"Crossref","is-referenced-by-count":0,"title":["Ionic Solid Matrices\nApplied via Low-Temperature Evaporation\nEnable High-Resolution and Sensitive MALDI Imaging of Metabolites"],"prefix":"10.1021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-0106","authenticated-orcid":true,"given":"Toufik","family":"Mahamdi","sequence":"first","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]},{"name":"CIBER de Diabetes y Enfermedades Metabo\u0301licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Molto\u0301","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]},{"name":"CIBER de Diabetes y Enfermedades Metabo\u0301licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Arasa","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0288-9619","authenticated-orcid":true,"given":"Roger","family":"Gine\u0301","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]},{"name":"CIBER de Diabetes y Enfermedades Metabo\u0301licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Rofes","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]},{"name":"CIBER de Diabetes y Enfermedades Metabo\u0301licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-1487","authenticated-orcid":true,"given":"Mari\u0301a","family":"Garci\u0301a-Altares","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9804-0171","authenticated-orcid":true,"given":"Maria","family":"Vinaixa","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]},{"name":"CIBER de Diabetes y Enfermedades Metabo\u0301licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , ,","place":["Madrid, Spain, 28029"]},{"name":"Institut de Recerca Biome\u0300dica Catalunya Sud, Hospital Universitari Sant Joan de Reus , , ,","place":["Reus, Spain, 43204"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3695-7157","authenticated-orcid":true,"given":"Oscar","family":"Yanes","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili , , ,","place":["Tarragona, Spain, 43007"]},{"name":"CIBER de Diabetes y Enfermedades Metabo\u0301licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , ,","place":["Madrid, Spain, 28029"]},{"name":"Institut de Recerca Biome\u0300dica Catalunya Sud, Hospital Universitari Sant Joan de Reus , , ,","place":["Reus, Spain, 43204"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026100710073221500_cit1","doi-asserted-by":"publisher","first-page":"116809","DOI":"10.1016\/j.trac.2022.116809","article-title":"Matrix-Assisted Laser Desorption\/Ionization Mass Spectrometry Imaging\n(MALDI MSI) for in Situ Analysis of Endogenous Small Molecules in\nBiological Samples","volume":"157","author":"Liu","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"key":"2026100710073221500_cit2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/978-3-030-51652-9_5","article-title":"Single-Cell Metabolomics\nby Mass Spectrometry Imaging","volume":"1280","author":"Duen\u0303as","year":"2021","journal-title":"Adv. Exp. Med.\nBiol."},{"key":"2026100710073221500_cit3","doi-asserted-by":"publisher","first-page":"117344","DOI":"10.1016\/j.trac.2023.117344","article-title":"Advances in Imaging Mass Spectrometry\nfor Biomedical and Clinical Research","volume":"169","author":"Djambazova","year":"2023","journal-title":"Trends\nAnal. Chem."},{"key":"2026100710073221500_cit4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0168-1176(91)85050-V","article-title":"2,5-Dihydroxybenzoic\nacid: A new\nmatrix for laser desorption\u2500ionization mass spectrometry","volume":"111","author":"Strupat","year":"1991","journal-title":"Int. J. Mass Spectrom. Ion Processes"},{"issue":"2","key":"2026100710073221500_cit5","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/oms.1210270217","article-title":"\u03b1-Cyano-4-Hydroxycinnamic\nAcid\nas a Matrix for Matrixassisted Laser Desorption Mass Spectromtry","volume":"27","author":"Beavis","year":"1992","journal-title":"Org. Mass Spectrom"},{"issue":"2","key":"2026100710073221500_cit6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S1044-0305(96)00233-4","article-title":"Mercaptobenzothiazoles:\nA New Class of Matrices for Laser Desorption Ionization Mass Spectrometry","volume":"8","author":"Xu","year":"1997","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"2026100710073221500_cit7","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/rcm.750","article-title":"9-Aminoacridine\nas a Matrix for Negative Mode Matrix-Assisted\nLaser Desorption\/Ionization","volume":"16","author":"Vermillion-Salsbury","year":"2002","journal-title":"Rapid Commun. Mass\nSpectrom."},{"key":"2026100710073221500_cit8","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1021\/ac2033547","article-title":"Sublimation of New\nMatrix Candidates for High Spatial Resolution Imaging Mass Spectrometry\nof Lipids: Enhanced Information in Both Positive and Negative Polarities\nafter 1,5-Diaminonapthalene Deposition","volume":"84","author":"Thomas","year":"2012","journal-title":"Anal.\nChem."},{"key":"2026100710073221500_cit9","doi-asserted-by":"publisher","first-page":"117727","DOI":"10.1016\/j.trac.2024.117727","article-title":"Recent Strategies for\nImproving MALDI Mass Spectrometry Imaging Performance towards Low\nMolecular Weight Compounds","volume":"175","author":"Sun","year":"2024","journal-title":"TrAC, Trends Anal.\nChem."},{"key":"2026100710073221500_cit10","doi-asserted-by":"publisher","first-page":"5160","DOI":"10.1021\/acs.analchem.3c05235","article-title":"2-Hydroxy-5-Nitro-3-(Trifluoromethyl)Pyridine\nas a\nNovel Matrix for Enhanced MALDI Imaging of Tissue Metabolites","volume":"96","author":"Bao","year":"2024","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit11","doi-asserted-by":"publisher","first-page":"18709","DOI":"10.1021\/acs.analchem.3c01731","article-title":"2,5-Dihydroxyterephthalic\nAcid: A Matrix for Improved Detection and Imaging of Amino Acids","volume":"95","author":"Fu","year":"2023","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit12","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1021\/ac2025317","article-title":"MALDI Imaging\nand Structural Analysis of Rat Brain Lipid Negative Ions with 9-Aminoacridine\nMatrix","volume":"84","author":"Cerruti","year":"2012","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit13","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1021\/ac504294s","article-title":"MALDI-TOF\nMS Imaging of Metabolites with a N-(1-Naphthyl) Ethylenediamine Dihydrochloride\nMatrix and Its Application to Colorectal Cancer Liver Metastasis","volume":"87","author":"Wang","year":"2015","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit14","doi-asserted-by":"publisher","first-page":"5988","DOI":"10.1021\/acs.analchem.6b01021","article-title":"On-Tissue\nDerivatization via Electrospray Deposition for Matrix-Assisted Laser\nDesorption\/Ionization Mass Spectrometry Imaging of Endogenous Fatty\nAcids in Rat Brain Tissues","volume":"88","author":"Wu","year":"2016","journal-title":"Anal. Chem."},{"issue":"8","key":"2026100710073221500_cit15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/jms.3411","article-title":"A Derivatization\nand Validation Strategy for Determining the Spatial Localization of\nEndogenous Amine Metabolites in Tissues Using MALDI Imaging Mass Spectrometry","volume":"49","author":"Manier","year":"2014","journal-title":"J. Mass Spectrom."},{"key":"2026100710073221500_cit16","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s13361-015-1119-9","article-title":"Pyrylium Salts as Reactive Matrices\nfor MALDI-MS Imaging of Biologically Active Primary Amines","volume":"26","author":"Shariatgorji","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"2026100710073221500_cit17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208908","article-title":"Assessing the Potential\nof Sputtered Gold Nanolayers in Mass Spectrometry Imaging for Metabolomics\nApplications","volume":"13","author":"Ra\u0300fols","year":"2018","journal-title":"PLoS One"},{"key":"2026100710073221500_cit18","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1002\/rcm.7848","article-title":"Improving the Analyte\nIon Signal in Matrix-Assisted\nLaser Desorption\/Ionization Imaging Mass Spectrometry via Electrospray\nDeposition by Enhancing Incorporation of the Analyte in the Matrix","volume":"31","author":"Malys","year":"2017","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"2026100710073221500_cit19","doi-asserted-by":"publisher","first-page":"10030","DOI":"10.1021\/ac5028534","article-title":"Optimization\nand Comparison of Multiple\nMALDI Matrix Application Methods for Small Molecule Mass Spectrometric\nImaging","volume":"86","author":"Gemperline","year":"2014","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit20","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.bbapap.2016.12.012","article-title":"Metabolomic Profiling\nof Prostate Cancer by Matrix\nAssisted Laser Desorption\/Ionization-Fourier Transform Ion Cyclotron\nResonance Mass Spectrometry Imaging Using Matrix Coating Assisted\nby an Electric Field (MCAEF)","volume":"1865","author":"Wang","year":"2017","journal-title":"Biochim. Biophys.\nActa BBA - Proteins Proteomics"},{"key":"2026100710073221500_cit21","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1021\/ac010259f","article-title":"Ionic Liquids as\nMatrixes for Matrix-Assisted Laser Desorption\/Ionization Mass Spectrometry","volume":"73","author":"Armstrong","year":"2001","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit22","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1007\/s13361-015-1202-2","article-title":"Investigations\nof Some Liquid Matrixes for Analyte Quantification by MALDI","volume":"26","author":"Moon","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"2026100710073221500_cit23","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.jasms.2004.08.011","article-title":"Ionic-Liquid Matrices\nfor Quantitative Analysis by\nMALDI-TOF Mass Spectrometry","volume":"15","author":"Li","year":"2004","journal-title":"J. Am. Soc. Mass\nSpectrom."},{"key":"2026100710073221500_cit24","doi-asserted-by":"publisher","first-page":"105983","DOI":"10.1016\/j.microc.2021.105983","article-title":"Review of the Applicability of Ionic\nLiquid Matrices for the Quantification of Small Molecules by MALDI\nMS","volume":"164","author":"Kobylis","year":"2021","journal-title":"Microchem. J."},{"key":"2026100710073221500_cit25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ab.2012.10.035","article-title":"Ionic Matrices\nPre-Spotted Matrix-Assisted Laser Desorption\/Ionization Plates for\nPatient Maker Following in Course of Treatment, Drug Titration, and\nMALDI Mass Spectrometry Imaging","volume":"434","author":"Bonnel","year":"2013","journal-title":"Anal. Biochem."},{"key":"2026100710073221500_cit26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.aca.2009.02.051","article-title":"MALDI Mass Spectrometry\nImaging of Gangliosides in Mouse Brain Using\nIonic Liquid Matrix","volume":"639","author":"Chan","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"2026100710073221500_cit27","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1021\/ac0514669","article-title":"Solid Ionic Matrixes\nfor Direct Tissue Analysis and\nMALDI Imaging","volume":"78","author":"Lemaire","year":"2006","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit28","doi-asserted-by":"publisher","first-page":"8800","DOI":"10.1021\/ac102422b","article-title":"Ionic Matrix for Enhanced\nMALDI Imaging Mass Spectrometry for Identification\nof Phospholipids in Mouse Liver and Cerebellum Tissue Sections","volume":"82","author":"Shrivas","year":"2010","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit29","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.jprot.2010.02.010","article-title":"Liquid Ionic\nMatrixes for MALDI Mass Spectrometry Imaging of Lipids","volume":"73","author":"Meriaux","year":"2010","journal-title":"J. Proteomics"},{"key":"2026100710073221500_cit30","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1021\/jasms.5c00015","article-title":"Improving MALDI Mass\nSpectrometry Imaging Performance: Low-Temperature Thermal Evaporation\nfor Controlled Matrix Deposition and Improved Image Quality","volume":"36","author":"Mahamdi","year":"2025","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"2026100710073221500_cit31","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1093\/bioinformatics\/btaa142","article-title":"rMSIproc:\nAn R Package\nfor Mass Spectrometry Imaging Data Processing","volume":"36","author":"Ra\u0300fols","year":"2020","journal-title":"Bioinformatics"},{"key":"2026100710073221500_cit32","doi-asserted-by":"publisher","first-page":"338669","DOI":"10.1016\/j.aca.2021.338669","article-title":"rMSIannotation: A peak annotation\ntool for mass spectrometry\nimaging based on the analysis of isotopic intensity ratios","volume":"1171","author":"Semente\u0301","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"2026100710073221500_cit33","doi-asserted-by":"publisher","first-page":"115570","DOI":"10.1016\/j.ab.2024.115570","article-title":"Spatially\nResolved Distribution of\nPancreatic Hormones Proteoforms by MALDI-Imaging Mass Spectrometry","volume":"692","author":"Sisnande","year":"2024","journal-title":"Anal. Biochem."},{"key":"2026100710073221500_cit34","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s00125-019-4855-8","article-title":"Imaging Mass Spectrometry Enables\nMolecular Profiling of Mouse and Human Pancreatic Tissue","volume":"62","author":"Prentice","year":"2019","journal-title":"Diabetologia"},{"key":"2026100710073221500_cit35","doi-asserted-by":"publisher","first-page":"6548","DOI":"10.1021\/acs.analchem.8b00161","article-title":"High Spatial Resolution\nImaging of Mouse Pancreatic Islets Using Nanospray Desorption Electrospray\nIonization Mass Spectrometry","volume":"90","author":"Yin","year":"2018","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit36","doi-asserted-by":"publisher","first-page":"100953","DOI":"10.1016\/j.molmet.2020.01.017","article-title":"De Novo Discovery of\nMetabolic Heterogeneity with Immunophenotype-Guided Imaging Mass Spectrometry","volume":"36","author":"Prade","year":"2020","journal-title":"Mol. Metab."},{"issue":"7","key":"2026100710073221500_cit37","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1007\/s00125-009-1359-y","article-title":"Melatonin Receptors\nin Pancreatic Islets: Good Morning to a Novel Type 2 Diabetes Gene","volume":"52","author":"Mulder","year":"2009","journal-title":"Diabetologia"},{"key":"2026100710073221500_cit38","first-page":"1044","article-title":"Pancreatic and Islet Development\nand Function: The\nRole of Thyroid Hormone","volume":"2","author":"Mastracci","year":"2014","journal-title":"J. Endocrinol. Diabetes\nObes."},{"key":"2026100710073221500_cit39","doi-asserted-by":"publisher","first-page":"2861034","DOI":"10.1155\/2018\/2861034","article-title":"The Roles of Thyroid and Thyroid\nHormone in Pancreas: Physiology and Pathology","volume":"2018","author":"Chen","year":"2018","journal-title":"Int. J. Endocrinol."},{"issue":"6","key":"2026100710073221500_cit40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039424","article-title":"MALDI\nImaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic\nLesions in Pancreatic Cancer","volume":"7","author":"Gru\u0308ner","year":"2012","journal-title":"PLoS One"},{"key":"2026100710073221500_cit41","doi-asserted-by":"publisher","first-page":"7682","DOI":"10.1021\/ac200888j","article-title":"Linking Mass Spectrometric\nImaging and Traditional\nPeptidomics: A Validation in the Obese Mouse Model","volume":"83","author":"Minerva","year":"2011","journal-title":"Anal. Chem."},{"key":"2026100710073221500_cit42","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1021\/acschembio.6b00602","article-title":"Single Cell Peptide\nHeterogeneity of Rat Islets of Langerhans","volume":"11","author":"Jansson","year":"2016","journal-title":"ACS\nChem. Biol."}],"container-title":["Journal of the American\nSociety for Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.6c00219","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/10\/2463\/68276230\/jasms.6c00219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/10\/2463\/68276230\/jasms.6c00219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:24:58Z","timestamp":1791383098000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jamsef\/article\/37\/10\/2463\/5412280\/Ionic-Solid-Matrices-Applied-via-Low-Temperature"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,3]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1021\/jasms.6c00219","relation":{},"ISSN":["1044-0305","1879-1123"],"issn-type":[{"value":"1044-0305","type":"print"},{"value":"1879-1123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]}}}