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To address these shortcomings, a fast analytical platform based on a thermal desorption unit that is directly interfaced with dielectric barrier discharge ionization mass spectrometry (TD-DBDI-MS) was developed. The integration of a heated nitrogen purge system effectively suppressed atmospheric background interference and improved signal stability. Moreover, a simplified liquid\u2013liquid extraction pretreatment protocol was established that eliminates the need for centrifugation and solid-phase extraction (SPE) cleanup steps. The complete analysis cycle time per sample was reduced by approximately 55% compared to conventional GC-MS\/LC-MS workflows, and each analysis by TD-DBDI-MS was completed in only 10 seconds. The method exhibited excellent linearity for four typical PAEs in the range of 0.5\u2013200.0 \u03bcg\/L with correlation coefficients (R2) &amp;gt; 0.998. The limits of detection (LOD) ranged from 0.11 to 0.52 \u03bcg\/kg, spike recoveries were between 82% and 106%, and relative standard deviations (RSDs) were &amp;lt;10%. Application to 19 commercially available food samples revealed widespread PAE contamination, with butyl benzyl phthalate (BBP) being detected in every sample. Contamination levels followed the order premade dishes &amp;gt; milk &amp;gt; sugary beverages. PAE migration levels from plastic bag packaging were significantly higher than those from plastic bottle and carton packaging. Fortunately, the measured PAE concentrations were all well below the specific migration limits (SMLs) specified in China\u2019s GB 5009.271-2016 regulation and EU Regulation 10\/2011. This rapid, efficient, and robust method provides a novel approach for large-scale screening of PAEs in complex food matrices.<\/jats:p>","DOI":"10.1021\/jasms.6c00286","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:01:58Z","timestamp":1790622118000},"page":"2598-2608","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Simultaneous\nQuantification of Four Typical\nPhthalate Esters in Complex Food Matrices via Thermal Desorption\u2013Dielectric\nBarrier Discharge Ionization Mass Spectrometry"],"prefix":"10.1021","volume":"37","author":[{"given":"Qisen","family":"Huang","sequence":"first","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Xiamen Municipal Center for Disease Control and Prevention , , ,","place":["Xiamen, Fujian Province, China, 361021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Guan","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chencheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-6044","authenticated-orcid":true,"given":"Xiaowen","family":"Yan","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-4358","authenticated-orcid":true,"given":"Renato","family":"Zenobi","sequence":"additional","affiliation":[{"name":"ETH Zurich , , ,","place":["Zurich, Switzerland, CH-8093"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026100710064180900_cit1","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1039\/D3GC03428C","article-title":"Global Environmental and Toxicological Data\nof Emerging Plasticizers: Current Knowledge, Regrettable Substitution\nDilemma, Green Solution and Future Perspectives","volume":"26","author":"Qadeer","year":"2024","journal-title":"Green Chem"},{"key":"2026100710064180900_cit2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12302-025-01117-6","article-title":"Release of High-Molecular-Weight\nPlasticizers from PVC: Mesocosm Experiments under Near-Natural Conditions","volume":"37","author":"Nagorka","year":"2025","journal-title":"Environ. 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Chromatogr"},{"key":"2026100710064180900_cit32","doi-asserted-by":"publisher","first-page":"5034","DOI":"10.1039\/D4AN00977K","article-title":"Rapid Detection\nof Aflatoxin B1, Zearalenone and Ochratoxin A in Grains\nby Thermal Desorption Dielectric Barrier Discharge Ionization Mass\nSpectrometry","volume":"149","author":"Zhao","year":"2024","journal-title":"Analyst"},{"key":"2026100710064180900_cit33","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1039\/D5AN00327J","article-title":"Identification of Plasticizers\nUsing Thermal Desorption Dielectric Barrier Discharge Ionization Mass\nSpectrometry","volume":"150","author":"Lu","year":"2025","journal-title":"Analyst"},{"issue":"24","key":"2026100710064180900_cit34","doi-asserted-by":"publisher","first-page":"14095","DOI":"10.1021\/acs.analchem.8b04437","article-title":"A \u201cSoft\u201d\nand \u201cHard\u201d Ionization Method for Comprehensive Studies\nof Molecules","volume":"90","author":"Wang","year":"2018","journal-title":"Anal. 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Master\u2019s Thesis, Heilongjiang Bayi Agricultural\nUniversity, 2024."}],"container-title":["Journal of the American\nSociety for Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jasms.6c00286","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/10\/2598\/68682257\/jasms.6c00286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jamsef\/article-pdf\/37\/10\/2598\/68682257\/jasms.6c00286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:49:32Z","timestamp":1791384572000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jamsef\/article\/37\/10\/2598\/5440290\/Rapid-Simultaneous-Quantification-of-Four-Typical"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,28]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1021\/jasms.6c00286","relation":{},"ISSN":["1044-0305","1879-1123"],"issn-type":[{"value":"1044-0305","type":"print"},{"value":"1879-1123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}