{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T14:03:40Z","timestamp":1682431420997},"reference-count":8,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2002,1,1]]},"DOI":"10.1021\/jf0107196","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:45:58Z","timestamp":1027658758000},"page":"495-498","source":"Crossref","is-referenced-by-count":1,"title":["Preparative-Scale Synthesis of Two Metabolites Isolated from Soil Treated with Zoxium Fungicide and Kerb Herbicide"],"prefix":"10.1021","volume":"50","author":[{"given":"Enrique L.","family":"Michelotti","sequence":"first","affiliation":[{"name":"Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477-0904, and Grup d'Enginyeria Molecular, Institut Qu\u00edmic de Sarri\u00e0, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 I.","family":"Borrell","sequence":"additional","affiliation":[{"name":"Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477-0904, and Grup d'Enginyeria Molecular, Institut Qu\u00edmic de Sarri\u00e0, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Roemmele","sequence":"additional","affiliation":[{"name":"Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477-0904, and Grup d'Enginyeria Molecular, Institut Qu\u00edmic de Sarri\u00e0, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep L.","family":"Matallana","sequence":"additional","affiliation":[{"name":"Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477-0904, and Grup d'Enginyeria Molecular, Institut Qu\u00edmic de Sarri\u00e0, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Teixid\u00f3","sequence":"additional","affiliation":[{"name":"Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477-0904, and Grup d'Enginyeria Molecular, Institut Qu\u00edmic de Sarri\u00e0, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois M.","family":"Bryman","sequence":"additional","affiliation":[{"name":"Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477-0904, and Grup d'Enginyeria Molecular, Institut Qu\u00edmic de Sarri\u00e0, Universitat Ramon Llull, Via Augusta, 390, E-08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"jf0107196b00001\/jf0107196b00001_1","unstructured":"Egan, A. R.; Michelotti, E. L.; Young, D. H.; Wilson, W.; Mattioda, H. RH-7281:\u2009 A Novel Fungicide for Control of Downy Mildew and Late Blight.Brighton Crop Protection Conference:\u2009 Pests Diseases; British Crop Protection Council:\u2009 Bracknell, U.K., 1998; Vol. 2, pp 335\u2212342."},{"key":"jf0107196b00002\/jf0107196b00002_1","unstructured":"Compound3, or 3 -(3,5-dichloro-4-methylbenzamido)-2-oxo-3-methylpentanoic acid, was recently isolated and identified from soil metabolism, soil column leaching, and aquatic sediment studies conducted with14C-RH-7281. For the soil metabolism study, metabolically active soil samples were treated with14C-RH-7281 to approximate the field rate of 0.2 kg a.i.\/ha. For the aged column leaching study, treated soil samples from the soil metabolism study were loaded onto a column of fresh soil and leached with water to simulate a rainfall event. For the water sediment study, water\/sediment systems in flasks were incubated with14C-RH-7281. For each of these studies, material balance analyses and identification of metabolites were performed. A complete report of this information will be reported in later publications. Compound3was isolated as a discrete14C entity in each of these studies. Proof of structure by mass spectrometry required isolation of sufficient quantities of material for HPLC\/MS analyses. Material for mass spectrometer identification was isolated from the combined samples of three studies. Extracts from the water phase of the water sediment study, extracts from soil column segments from the column leaching study, and soil extracts from the soil metabolism study were combined to obtain sufficient material. Confirmation of structure was obtained by chemical synthesis of compound3and comparison of mass spectra and chromatographic behavior."},{"key":"jf0107196b00003\/jf0107196b00003_1","first-page":"319","volume":"19","author":"Yih R. Y.","year":"1971","journal-title":"J. Agric. Food Chem"},{"key":"jf0107196b00004\/jf0107196b00004_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1021\/ja01633a046","volume":"76","author":"Sjolander J. R.","year":"1954","journal-title":"J. Am. Chem. Soc"},{"key":"jf0107196b00005\/jf0107196b00005_1","first-page":"1621","volume":"1","author":"Kato K.","year":"1980","journal-title":"J. Chem. Soc., Perkin Trans."},{"key":"jf0107196b00006\/jf0107196b00006_1","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1021\/jo00406a041","volume":"43","author":"Mancuso A. J.","year":"1978","journal-title":"J. Org. Chem"},{"key":"jf0107196b00007\/jf0107196b00007_1","unstructured":"Reibach, P. H.; Burgener, A. Unpublished Rohm and Haas Technical Report 1998. TR34-98-45."},{"key":"jf0107196b00008\/jf0107196b00008_1","unstructured":"Reibach, P. H.; V\u00f6lkel, W. Unpublished Rohm and Haas Technical Report 1998. TR34-98-47."}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jf0107196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T08:16:13Z","timestamp":1680768973000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jf0107196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,21]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["10.1021\/jf0107196"],"URL":"https:\/\/doi.org\/10.1021\/jf0107196","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,21]]}}}