{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:35:12Z","timestamp":1782941712943,"version":"3.54.5"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2011,4,13]]},"DOI":"10.1021\/jf104831n","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T19:58:26Z","timestamp":1299182306000},"page":"3420-3428","source":"Crossref","is-referenced-by-count":32,"title":["Arecoline<i>N<\/i>-Oxide: Its Mutagenicity and Possible Role as Ultimate Carcinogen in Areca Oral Carcinogenesis"],"prefix":"10.1021","volume":"59","author":[{"given":"Kuo-Hui","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chih","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Young","family":"Chou","sequence":"additional","affiliation":[{"name":"College of Oral Medicine, Chung-Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Kun","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Oral Medicine, Chung-Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,3,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13556210020091437","volume":"7","author":"Gupta P. C.","year":"2002","journal-title":"Addict. Biol."},{"key":"ref2\/cit2","first-page":"1","volume":"85","year":"2004","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"ref3\/cit3","first-page":"124","volume":"12","author":"Bhargava K.","year":"1975","journal-title":"Indian J. Cancer"},{"key":"ref4\/cit4","first-page":"437","volume":"63","author":"Chang K. M.","year":"1964","journal-title":"Tsa Chih Gaoxiong Yi Xue Yuan Tong Xue Hui"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1136\/bmj.324.7341.799","volume":"324","author":"Warnakulasuriya S.","year":"2002","journal-title":"BMJ"},{"key":"ref6\/cit6","first-page":"646","volume":"11","author":"Chiu C. J.","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref7\/cit7","first-page":"901","volume":"6","author":"Hung H. C.","year":"1997","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-0714.1995.tb01132.x","volume":"24","author":"Ko Y. C.","year":"1995","journal-title":"J. Oral Pathol. Med."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1600-0714.1996.tb01379.x","volume":"25","author":"Lu C. T.","year":"1996","journal-title":"J. Oral Pathol. Med."},{"key":"ref10\/cit10","first-page":"1879s","volume":"54","author":"Miller J. A.","year":"1994","journal-title":"Cancer Res."},{"key":"ref11\/cit11","first-page":"559","volume":"30","author":"Miller J. A.","year":"1970","journal-title":"Cancer Res."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1073\/pnas.70.8.2281","volume":"70","author":"Ames B. N.","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/carcin\/21.3.345","volume":"21","author":"Guengerich F. P.","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-1161(83)90010-9","volume":"113","author":"Maron D. M.","year":"1983","journal-title":"Mutat. Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/mutage\/10.6.517","volume":"10","author":"Callander R. D.","year":"1995","journal-title":"Mutagenesis"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/bj1220503","volume":"122","author":"Nery R.","year":"1971","journal-title":"Biochem. J."},{"key":"ref17\/cit17","first-page":"2058","volume":"32","author":"Garner R. C.","year":"1972","journal-title":"Cancer Res."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/tx0600402","volume":"19","author":"Giri S.","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0021-9258(18)65874-0","volume":"218","author":"Vogel H. J.","year":"1956","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0076-6879(55)01020-3","volume":"1","author":"Gomori G.","year":"1955","journal-title":"Methods Enzymol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0964-1955(96)00018-8","volume":"32","author":"Jin Y. T.","year":"1996","journal-title":"Eur. J. Cancer B: Oral Oncol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/0970-9290.29881","volume":"17","author":"Saraswathi T. R.","year":"2006","journal-title":"Indian J. Dent. Res."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.oraloncology.2003.12.015","volume":"40","author":"Chiang C. P.","year":"2004","journal-title":"Oral Oncol."},{"key":"ref24\/cit24","first-page":"3919","volume":"51","author":"Kataoka K.","year":"1991","journal-title":"Cancer Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bcp.2006.10.017","volume":"73","author":"Giri S.","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","unstructured":"Lin, J. K.; Kuo, M. L.; Hsu, L. W.Studies on the Genotoxicity of Dipyridyl and Biphenyl Derivatives Using Salmonella typhimurium,3rded. 1988; pp161\u2212171.","DOI":"10.1002\/tox.2540030207"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0090-9556(24)02980-5","volume":"32","author":"Kulanthaivel P.","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.oraloncology.2006.08.010","volume":"43","author":"Zhang X.","year":"2007","journal-title":"Oral Oncol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/03014460210157448","volume":"30","author":"Strickland S. S.","year":"2003","journal-title":"Ann. Hum. Biol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/carcin\/23.8.1361","volume":"23","author":"Tanaka T.","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/carcin\/6.2.295","volume":"6","author":"Nair J.","year":"1985","journal-title":"Carcinogenesis"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.etp.2007.02.010","volume":"59","author":"Silva R. N.","year":"2007","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/0030-4220(85)90189-6","volume":"59","author":"Ohne M.","year":"1985","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<128::AID-IJC20>3.0.CO;2-M","volume":"86","author":"Merchant A.","year":"2000","journal-title":"Int. J. Cancer"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1177\/00220345940730050501","volume":"73","author":"Jeng J. H.","year":"1994","journal-title":"J. Dent. Res."}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jf104831n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T05:54:32Z","timestamp":1740981272000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jf104831n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,3]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,4,13]]}},"alternative-id":["10.1021\/jf104831n"],"URL":"https:\/\/doi.org\/10.1021\/jf104831n","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,3]]}}}