{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:30:30Z","timestamp":1776695430412,"version":"3.51.2"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"43","funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2012GB23600641"],"award-info":[{"award-number":["2012GB23600641"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Forestry Bureau","award":["2012-4-06"],"award-info":[{"award-number":["2012-4-06"]}]},{"name":"Heilongjiang Province Science Foundation for Excellent Youths","award":["JC200704"],"award-info":[{"award-number":["JC200704"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2014,10,29]]},"DOI":"10.1021\/jf501635a","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T01:38:13Z","timestamp":1412213893000},"page":"10604-10614","source":"Crossref","is-referenced-by-count":8,"title":["In Vitro Oxidative Metabolism of Cajaninstilbene Acid by Human Liver Microsomes and Hepatocytes: Involvement of Cytochrome P450 Reaction Phenotyping, Inhibition, and Induction Studies"],"prefix":"10.1021","volume":"62","author":[{"given":"Xin","family":"Hua","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuangang","family":"Zu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Smyth","sequence":"additional","affiliation":[{"name":"College of Pharmacy, The University of Texas at Austin, 1 University Station, A1920, Austin, Texas 78712, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1515\/znc-1976-9-1005","volume":"31","author":"Ingham J. L.","year":"1976","journal-title":"Z. Naturforsch. C"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/0031-9422(80)85072-2","volume":"21","author":"Cooksey C. J.","year":"1980","journal-title":"Phytochemistry"},{"key":"ref3\/cit3","volume-title":"Compositions Containing Hyportriglyceridemically Active Stilbenenoids","author":"Inman W. D.","year":"2002"},{"key":"ref4\/cit4","unstructured":"Inman, W. D.; Hoppe, D. C.Compositions containing hypoglucemically active stilbenoids. U.S. Patent, Insemed Inc., Glen Allen, VA, USA, 2003."},{"key":"ref5\/cit5","first-page":"562","volume":"42","author":"Zheng Y. Y.","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"ref6\/cit6","first-page":"147","volume":"26","author":"Sun S. M.","year":"1995","journal-title":"Chin. Tradit. Herb Drugs"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3390\/molecules14031032","volume":"14","author":"Wu N.","year":"2009","journal-title":"Molecules"},{"key":"ref8\/cit8","unstructured":"Fu, Y. J.; Zu, Y. G.; Liu, X.; Wu, N.; Kong, Y.; Luo, M.; Gu, C. B.; Peng, X.Apply of cajanin leaves supercritical carbon dioxide extraction and cajaninstilbene acid anti-tumor drug preparation. CN101569654B, 2011."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jpba.2010.01.004","volume":"52","author":"Hua X.","year":"2010","journal-title":"J. Pharm. Biomed."},{"key":"ref10\/cit10","unstructured":"FDA. Guidance for Industry: Drug Interaction Studies\u2014Study Design, Data Analysis and Implications for Dosing and Labeling,http:\/\/www.fda.gov\/cber\/guidelines.htm, 2006."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/1389200003339018","volume":"1","author":"Thompson T. N.","year":"2000","journal-title":"Curr. Drug Metab."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/1386207013331101","volume":"4","author":"Masimirembwa C. M.","year":"2001","journal-title":"Comb. Chem. High Throughput Screening"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/dmd.31.7.815","volume":"31","author":"Bjornsson T. D.","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","volume":"360","author":"Nebert D. W.","year":"2002","journal-title":"Lancet"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/9780470191699.ch2","volume-title":"Drug Metabolism in Drug Design and Development","author":"Guengerich F. P.","year":"2007"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1124\/dmd.111.039776","volume":"39","author":"Hong H.","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.foodchem.2009.03.091","volume":"117","author":"Kong Y.","year":"2009","journal-title":"Food Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1124\/jpet.103.049601","volume":"306","author":"Ward B. A.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2217\/14622416.8.6.547","volume":"8","author":"Desta Z.","year":"2007","journal-title":"Pharmacogenomics"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0090-9556(25)06500-6","volume":"23","author":"Newton D. J.","year":"1995","journal-title":"Drug Metab. Dispos."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0022-3565(25)12826-7","volume":"277","author":"Bourri\u00e9 M.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/dmd.30.5.525","volume":"30","author":"Rae J. M.","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1124\/dmd.110.033886","volume":"38","author":"Feidt D. M.","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1124\/dmd.109.029694","volume":"38","author":"Wang L.","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/0006-2952(90)90095-3","volume":"40","author":"Wortelboer H. M.","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0090-9556(24)15146-X","volume":"28","author":"Robertson P.","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"ref27\/cit27","unstructured":"GraphPad Prism 5.0.GraphPad Software Inc.,San Diego, CA, USA;www.graphpad.com."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-3565(25)10619-8","volume":"274","author":"Ashforth E. I.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3109\/03602539709002237","volume":"29","author":"Houston J. B.","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF01059791","volume":"1","author":"Rowland M.","year":"1973","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2165\/00003088-199835050-00003","volume":"35","author":"Lin J. H.","year":"1998","journal-title":"Clin. Pharmacokinet."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0022-3565(25)22379-5","volume":"270","author":"Shimada T.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/1568026013395001","volume":"1","author":"Yan Z.","year":"2001","journal-title":"Curr. Top. Med. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2165\/00003088-199835050-00003","volume":"35","author":"Lin J. H.","year":"1998","journal-title":"Clin. Pharmacokinet."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2004.08.141","volume":"323","author":"Gilly R. S.","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-4274(01)00418-0","volume":"125","author":"Piver B.","year":"2001","journal-title":"Toxicol. Lett."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1016\/S0024-3205(00)00888-2","volume":"67","author":"Chan W. K.","year":"2000","journal-title":"Life Sci."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0024-3205(03)00420-X","volume":"73","author":"Piver B.","year":"2003","journal-title":"Life Sci."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0009-2797(01)00163-6","volume":"134","author":"LeCluyse E. L.","year":"2001","journal-title":"Chem.\u2013Biol. Interact."}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jf501635a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T23:37:14Z","timestamp":1746401834000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jf501635a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":39,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2014,10,29]]}},"alternative-id":["10.1021\/jf501635a"],"URL":"https:\/\/doi.org\/10.1021\/jf501635a","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]}}}