{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:59:58Z","timestamp":1772805598522,"version":"3.50.1"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2001,2,1]]},"DOI":"10.1021\/jm0003900","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:53:54Z","timestamp":1027659234000},"page":"453-467","source":"Crossref","is-referenced-by-count":94,"title":["GnRH Antagonists:\u2009 A New Generation of Long Acting Analogues Incorporating<i>p<\/i>-Ureido-phenylalanines at Positions 5 and 6"],"prefix":"10.1021","volume":"44","author":[{"given":"Guangcheng","family":"Jiang","sequence":"first","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Stalewski","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Galyean","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dykert","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Schteingart","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Broqua","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Aebi","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel L.","family":"Aubert","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Semple","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Robson","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Akinsanya","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Haigh","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Riviere","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Trojnar","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Louis","family":"Junien","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean E.","family":"Rivier","sequence":"additional","affiliation":[{"name":"Ferring Research Institute Inc., San Diego, California 92121, Department of Pediatrics, University of Geneva, School of Medicine, 1211 Geneva 14, Switzerland, Ferring Research Institute Ltd., Southampton SO16 7NP, U.K., Ferring SAS, 216 Boulevard Saint Germain, 75007 Paris, France, and The Salk Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2000,12,14]]},"reference":[{"key":"jm0003900b00001\/jm0003900b00001_1","unstructured":"Lunenfeld, B.; Insler, V. GnRH Analogues.The State of the Art 1993; The Parthenon Publishing Group:\u2009 Carnforth, Lancaster, 1993; pp 1\u2212156."},{"key":"jm0003900b00002\/jm0003900b00002_1","unstructured":"Lunenfeld, B.; Insler, V. GnRH Analogues.The State of the Art 1996; The Parthenon Publishing Group:\u2009 Carnforth, Lancaster, 1996; pp 1\u2212190."},{"key":"jm0003900b00003\/jm0003900b00003_1","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0015-0282(97)00408-1","volume":"68","author":"Lunenfeld B.","year":"1997","journal-title":"Fertil. Steril."},{"key":"jm0003900b00004\/jm0003900b00004_1","unstructured":"Lunenfeld, B.; GnRH Analogues.The State of the Art at the Millennium; The Parthenon Publishing Group:\u2009 New York, 1999; pp 1\u2212136."},{"key":"jm0003900b00005\/jm0003900b00005_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1399-3011.1988.tb01373.x","volume":"32","author":"Bajusz S.","year":"1988","journal-title":"Int. J. Pept. Protein Res."},{"key":"jm0003900b00006\/jm0003900b00006_1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1021\/jm00160a008","volume":"29","author":"Rivier J.","year":"1986","journal-title":"J. Med. Chem."},{"key":"jm0003900b00007\/jm0003900b00007_1","first-page":"3948","volume":"35","author":"Nestor J. J. J.","year":"1992","journal-title":"J. Med. Chem."},{"key":"jm0003900b00008\/jm0003900b00008_1","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1021\/jm00101a003","volume":"35","author":"Rivier J.","year":"1992","journal-title":"J. Med. Chem."},{"key":"jm0003900b00009\/jm0003900b00009_1","first-page":"268","volume":"2","author":"Molineaux C. J.","year":"1998","journal-title":"Mol. Urol."},{"key":"jm0003900b00010\/jm0003900b00010_1","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1021\/jm00112a013","volume":"34","author":"Theobald P.","year":"1991","journal-title":"J. Med. Chem."},{"key":"jm0003900b00011\/jm0003900b00011_1","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1021\/jm00014a017","volume":"38","author":"Rivier J. E.","year":"1995","journal-title":"J. Med. Chem."},{"key":"jm0003900b00012\/jm0003900b00012_1","first-page":"45","volume-title":"GnRH Analogues \u2212 The State of the Art at the Millennium","author":"Rivier J.","year":"1999"},{"key":"jm0003900b00013\/jm0003900b00013_1","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.1021\/ja00053a003","volume":"114","author":"Searle M. S.","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"jm0003900b00014\/jm0003900b00014_1","doi-asserted-by":"crossref","first-page":"10704","DOI":"10.1021\/ja00053a004","volume":"114","author":"Searle M. S.","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"jm0003900b00015\/jm0003900b00015_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1097-0282(1996)40:3<265::AID-BIP2>3.0.CO;2-U","volume":"40","author":"Miller C.","year":"1996","journal-title":"Biopolymers"},{"key":"jm0003900b00016\/jm0003900b00016_1","first-page":"310","volume":"404","author":"Hoeger C. A.","year":"1989","journal-title":"J. Chromatogr."},{"key":"jm0003900b00017\/jm0003900b00017_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1399-3011.1993.tb00487.x","volume":"42","author":"Kaljuste K.","year":"1993","journal-title":"Int. J. Pept. Protein Res."},{"key":"jm0003900b00018\/jm0003900b00018_1","first-page":"3748","volume":"40","author":"Jiang G.","year":"1997","journal-title":"J. Med. Chem."},{"key":"jm0003900b00019\/jm0003900b00019_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0003-2697(72)90129-7","volume":"47","author":"Hakanson R.","year":"1972","journal-title":"Anal. Biochem."},{"key":"jm0003900b00020\/jm0003900b00020_1","first-page":"594","volume-title":"Proceedings of the PEPTIDES 1988, Proceedings of 20th European Peptide Symposium; Jung, G., Bayer, E., Eds.; Walter de Gruyter & Co.:\u2009 Berlin","author":"Nestor J. J."},{"key":"jm0003900b00021\/jm0003900b00021_1","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1210\/endo.140.9.6985","volume":"140","author":"Raposinho P.","year":"1999","journal-title":"Endocrinology"},{"key":"jm0003900b00022\/jm0003900b00022_1","first-page":"933","volume":"36","author":"Haviv F.","year":"1993","journal-title":"J. Med. Chem."},{"key":"jm0003900b00023\/jm0003900b00023_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1021\/jm00349a006","volume":"25","author":"Nestor J. J.","year":"1982","journal-title":"J. Med. Chem."},{"key":"jm0003900b00024\/jm0003900b00024_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1021\/jm00225a018","volume":"19","author":"Coy D. H.","year":"1976","journal-title":"J. Med. Chem."},{"key":"jm0003900b00025\/jm0003900b00025_1","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1021\/jm00365a001","volume":"26","author":"Rivier C.","year":"1983","journal-title":"J. Med. Chem."},{"key":"jm0003900b00026\/jm0003900b00026_1","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/jm00375a016","volume":"27","author":"Nestor J. J.","year":"1984","journal-title":"J. Med. Chem."},{"key":"jm0003900b00027\/jm0003900b00027_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/edrv.18.2.0295","volume":"18","author":"Sealfon S. C.","year":"1997","journal-title":"Endocrine Rev."},{"key":"jm0003900b00028\/jm0003900b00028_1","doi-asserted-by":"crossref","first-page":"28886","DOI":"10.1074\/jbc.274.41.28880","volume":"274","author":"Flanagan C. A.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"jm0003900b00029\/jm0003900b00029_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1021\/jm990118u","volume":"43","author":"Koerber S. C.","year":"2000","journal-title":"J. Med. Chem."},{"key":"jm0003900b00030\/jm0003900b00030_1","first-page":"679","volume":"127","author":"Chan R. L.","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"jm0003900b00031\/jm0003900b00031_1","volume-title":"Clinical pharmacology of azaline B. Gynecological Endocrinology","author":"Hutchison J."},{"key":"jm0003900b00032\/jm0003900b00032_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/0006-2952(95)00027-W","volume":"49","author":"Campen C. A.","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"jm0003900b00033\/jm0003900b00033_1","volume-title":"Pharmacology and pharmacokinetics of abarelix-depot, a novel, long-acting formulation of the GnRH antagonist abarelix. Gynecological Endocrinology","author":"Molineaux C. J."},{"key":"jm0003900b00034\/jm0003900b00034_1","first-page":"224","volume":"3","author":"Jiang G.-C.","year":"1996","journal-title":"Protein Pept. Lett."},{"key":"jm0003900b00035\/jm0003900b00035_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/00304949009356330","volume":"22","author":"Stanfield C. F.","year":"1990","journal-title":"Org. Prep. Proced. Int."},{"key":"jm0003900b00036\/jm0003900b00036_1","first-page":"11","volume":"1","author":"Schneider F","year":"1937","journal-title":"Chem."},{"key":"jm0003900b00037\/jm0003900b00037_1","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1021\/ja01119a076","volume":"75","author":"Miller C. S.","year":"1953","journal-title":"J. Am. Chem. Soc."},{"key":"jm0003900b00038\/jm0003900b00038_1","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1021\/ja00897a025","volume":"85","author":"Merrifield R. B","year":"1963","journal-title":"J. Am. Chem. Soc."},{"key":"jm0003900b00039\/jm0003900b00039_1","first-page":"176","volume-title":"Solid-Phase Peptide Synthesis","author":"Stewart J. M.","year":"1984"},{"key":"jm0003900b00040\/jm0003900b00040_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/0003-2697(70)90146-6","volume":"34","author":"Kaiser E.","year":"1970","journal-title":"Anal. Biochem."},{"key":"jm0003900b00041\/jm0003900b00041_1","first-page":"142","volume":"2","author":"Hoeger C. A.","year":"1987","journal-title":"Biochromatography"},{"key":"jm0003900b00042\/jm0003900b00042_1","first-page":"573","volume":"134","author":"Kay T. W.","year":"1994","journal-title":"Endocrinology"},{"key":"jm0003900b00043\/jm0003900b00043_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1399-3011.1996.tb01107.x","volume":"48","author":"Michael K.","year":"1996","journal-title":"Int. J. Pept. Protein. Res."},{"key":"jm0003900b00044\/jm0003900b00044_1","first-page":"336","volume-title":"Proceedings of the 20th European Peptide Symposium; Jung, G., Bayer, E., Eds.; Walter de Gruyter & Co.:\u2009 Berlin","author":"Konig W."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm0003900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T20:27:07Z","timestamp":1704227227000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm0003900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,14]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,2,1]]}},"alternative-id":["10.1021\/jm0003900"],"URL":"https:\/\/doi.org\/10.1021\/jm0003900","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,14]]}}}