{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:23:11Z","timestamp":1789748591431,"version":"4.0.1"},"reference-count":0,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1991,4]]},"DOI":"10.1021\/jm00108a008","type":"journal-article","created":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T11:14:17Z","timestamp":1111144457000},"page":"1292-1296","source":"Crossref","is-referenced-by-count":48,"title":["Role of the spacer in conferring .kappa. opioid receptor selectivity to bivalent ligands related to norbinaltorphimine"],"prefix":"10.1021","volume":"34","author":[{"given":"P. S.","family":"Portoghese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garzon-Aburbeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Takemori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2002,5,1]]},"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm00108a008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T21:14:45Z","timestamp":1682284485000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jm00108a008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["10.1021\/jm00108a008"],"URL":"https:\/\/doi.org\/10.1021\/jm00108a008","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4]]}}}