{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:38:22Z","timestamp":1778909902918,"version":"3.51.4"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2003,5,1]]},"DOI":"10.1021\/jm0211218","type":"journal-article","created":{"date-parts":[[2003,5,15]],"date-time":"2003-05-15T05:58:24Z","timestamp":1052978304000},"page":"2083-2092","source":"Crossref","is-referenced-by-count":46,"title":["Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene\u2212Hopene Cyclase"],"prefix":"10.1021","volume":"46","author":[{"given":"Alexander","family":"Lenhart","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Biochemie, Albert-Ludwigs-Universit\u00e4t, Albertstrasse 21, Freiburg im Breisgau 79104, Germany, and Preclinical Research, Pharmaceuticals Division, Hoffmann-La Roche Ltd., Basel 4070, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J.","family":"Reinert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Biochemie, Albert-Ludwigs-Universit\u00e4t, Albertstrasse 21, Freiburg im Breisgau 79104, Germany, and Preclinical Research, Pharmaceuticals Division, Hoffmann-La Roche Ltd., Basel 4070, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes D.","family":"Aebi","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Biochemie, Albert-Ludwigs-Universit\u00e4t, Albertstrasse 21, Freiburg im Breisgau 79104, Germany, and Preclinical Research, Pharmaceuticals Division, Hoffmann-La Roche Ltd., Basel 4070, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrietta","family":"Dehmlow","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Biochemie, Albert-Ludwigs-Universit\u00e4t, Albertstrasse 21, Freiburg im Breisgau 79104, Germany, and Preclinical Research, Pharmaceuticals Division, Hoffmann-La Roche Ltd., Basel 4070, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver H.","family":"Morand","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Biochemie, Albert-Ludwigs-Universit\u00e4t, Albertstrasse 21, Freiburg im Breisgau 79104, Germany, and Preclinical Research, Pharmaceuticals Division, Hoffmann-La Roche Ltd., Basel 4070, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg E.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Biochemie, Albert-Ludwigs-Universit\u00e4t, Albertstrasse 21, Freiburg im Breisgau 79104, Germany, and Preclinical Research, Pharmaceuticals Division, Hoffmann-La Roche Ltd., Basel 4070, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2003,4,30]]},"reference":[{"key":"jm0211218b00001\/jm0211218b00001_1","first-page":"2206","volume":"90","author":"Abe I.","year":"1993","journal-title":"Chem. Rev."},{"key":"jm0211218b00002\/jm0211218b00002_1","first-page":"2833","volume":"39","author":"Wendt K. U.","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"jm0211218b00003\/jm0211218b00003_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0022-2275(20)37643-4","volume":"37","author":"Mark M.","year":"1996","journal-title":"J. Lipid Res."},{"key":"jm0211218b00004\/jm0211218b00004_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0022-2275(20)37449-6","volume":"38","author":"Morand O. H.","year":"1997","journal-title":"J. Lipid Res."},{"key":"jm0211218b00005\/jm0211218b00005_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0022-2275(20)37264-3","volume":"38","author":"Eisele B.","year":"1997","journal-title":"J. Lipid Res."},{"key":"jm0211218b00006\/jm0211218b00006_1","first-page":"1311","volume":"42","author":"Brown G. R.","year":"1999","journal-title":"J. Med. Chem."},{"key":"jm0211218b00007\/jm0211218b00007_1","first-page":"2979","volume":"39","author":"Brown G. R.","year":"1996","journal-title":"J. Med. Chem."},{"key":"jm0211218b00008\/jm0211218b00008_1","doi-asserted-by":"crossref","first-page":"30617","DOI":"10.1074\/jbc.M004132200","volume":"275","author":"Pandit J.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"jm0211218b00009\/jm0211218b00009_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0022-2275(20)32020-4","volume":"41","author":"Hiyoshi H.","year":"2000","journal-title":"J. Lipid Res."},{"key":"jm0211218b00010\/jm0211218b00010_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0014-2999(01)01411-X","volume":"431","author":"Sawada M.","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"jm0211218b00011\/jm0211218b00011_1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1126\/science.1059344","volume":"292","author":"Istvan E. S.","year":"2001","journal-title":"Science"},{"key":"jm0211218b00012\/jm0211218b00012_1","first-page":"114","volume":"56","author":"Illingworth D. R.","year":"2001","journal-title":"Adv. Protein Chem."},{"key":"jm0211218b00013\/jm0211218b00013_1","first-page":"277","volume":"1212","author":"Gr\u00fcnler J.","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"jm0211218b00014\/jm0211218b00014_1","first-page":"373","volume":"33","author":"Cattel L.","year":"1997","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"jm0211218b00015\/jm0211218b00015_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0223-5234(94)90121-X","volume":"29","author":"Grosa G.","year":"1994","journal-title":"Eur. J. Med. Chem."},{"key":"jm0211218b00016\/jm0211218b00016_1","first-page":"398","volume":"13","author":"Abe I.","year":"1998","journal-title":"J. Enzyme Inhib."},{"key":"jm0211218b00017\/jm0211218b00017_1","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1046\/j.1432-1033.2002.02861.x","volume":"269","author":"Milla P.","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"jm0211218b00018\/jm0211218b00018_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF02534300","volume":"21","author":"Cattel L.","year":"1986","journal-title":"Lipids"},{"key":"jm0211218b00019\/jm0211218b00019_1","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/0006-2952(88)90542-4","volume":"37","author":"Gerst N.","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"jm0211218b00020\/jm0211218b00020_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/0006-2952(95)00201-A","volume":"50","author":"Viola F.","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"jm0211218b00021\/jm0211218b00021_1","first-page":"103","volume":"4","author":"Rose I. C.","year":"1996","journal-title":"Bioorg. Med. Chem."},{"key":"jm0211218b00022\/jm0211218b00022_1","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1021\/jo990237h","volume":"64","author":"Ganem B.","year":"1999","journal-title":"J. Org. Chem."},{"key":"jm0211218b00023\/jm0211218b00023_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1248\/cpb.50.316","volume":"50","author":"Binet J.","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"jm0211218b00024\/jm0211218b00024_1","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/(SICI)1521-3773(19980904)37:16<2237::AID-ANIE2237>3.0.CO;2-9","volume":"37","author":"Pale-Grosdemange C.","year":"1998","journal-title":"Angew. Chem. Int. Ed."},{"key":"jm0211218b00025\/jm0211218b00025_1","unstructured":"Jolidon, S.; Polak-Wyss, A.; Hartman, P. G.; Guerry, P. 2,3-Oxidosqualene-lanosterol cyclase:\u2009 an attractive target for antifungal drug design. InRecent Advances in the Chemistry of Anti-Infective Agents; Bentley, P. H., Ed.; Royal Society of Chemistry:\u2009 Cambridge, 1993; pp 223\u2212233."},{"key":"jm0211218b00026\/jm0211218b00026_1","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1126\/science.277.5333.1811","volume":"277","author":"Wendt K. U.","year":"1997","journal-title":"Science"},{"key":"jm0211218b00027\/jm0211218b00027_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/jmbi.1998.2470","volume":"286","author":"Wendt K. U.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"jm0211218b00028\/jm0211218b00028_1","first-page":"134","volume":"1","author":"James R. W","year":"1948","journal-title":"Acta Crystallogr."},{"key":"jm0211218b00029\/jm0211218b00029_1","doi-asserted-by":"crossref","first-page":"13455","DOI":"10.1021\/bi010957u","volume":"40","author":"Raman C. S.","year":"2001","journal-title":"Biochemistry"},{"key":"jm0211218b00030\/jm0211218b00030_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1126\/science.271.5246.163","volume":"271","author":"Dougherty D. A","year":"1996","journal-title":"Science"},{"key":"jm0211218b00031\/jm0211218b00031_1","first-page":"1324","volume":"97","author":"Ma J. C.","year":"1997","journal-title":"Chem. Rev."},{"key":"jm0211218b00032\/jm0211218b00032_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1126\/science.3892686","volume":"229","author":"Burley S. K.","year":"1985","journal-title":"Science"},{"key":"jm0211218b00033\/jm0211218b00033_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1006\/jmbi.2000.4473","volume":"307","author":"Brandl M.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"jm0211218b00034\/jm0211218b00034_1","first-page":"5784","volume":"37","author":"Abe I.","year":"1998","journal-title":"Biochemistry"},{"key":"jm0211218b00035\/jm0211218b00035_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1074-5521(02)00138-2","volume":"9","author":"Lenhart A.","year":"2002","journal-title":"Chem. Biol."},{"key":"jm0211218b00036\/jm0211218b00036_1","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1021\/jm9504621","volume":"39","author":"Barth M. M.","year":"1996","journal-title":"J. Med. Chem."},{"key":"jm0211218b00037\/jm0211218b00037_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/jcc.10147","volume":"24","author":"Schulz-Gasch T.","year":"2003","journal-title":"J. Comput. Chem."},{"key":"jm0211218b00038\/jm0211218b00038_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1107\/S0907444900008568","volume":"56","author":"Ghosh M.","year":"2000","journal-title":"Acta Crystallogr., Sect. D"},{"key":"jm0211218b00039\/jm0211218b00039_1","first-page":"323","volume":"295","author":"Li R.","year":"2000","journal-title":"J. Mol. Biol."},{"key":"jm0211218b00040\/jm0211218b00040_1","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1021\/jm00378a021","volume":"27","author":"Andrews P. R.","year":"1984","journal-title":"J. Med. Chem."},{"key":"jm0211218b00041\/jm0211218b00041_1","first-page":"1178","volume":"90","author":"Williams D. H.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm0211218b00042\/jm0211218b00042_1","first-page":"256","volume":"8","author":"B\u00f6hm H. J","year":"1994","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"jm0211218b00043\/jm0211218b00043_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/pro.5560060617","volume":"6","author":"Froloff N.","year":"1997","journal-title":"Protein Sci."},{"key":"jm0211218b00044\/jm0211218b00044_1","first-page":"8311","volume":"113","author":"Cramer C. J.","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"jm0211218b00045\/jm0211218b00045_1","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1021\/ja00075a006","volume":"115","author":"Kearney P. C.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"jm0211218b00046\/jm0211218b00046_1","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1021\/jm990224w","volume":"42","author":"Carlier P. R.","year":"1999","journal-title":"J. Med. Chem."},{"key":"jm0211218b00047\/jm0211218b00047_1","first-page":"301","volume":"291","author":"Hoshino T.","year":"2002","journal-title":"Chem. Commun."},{"key":"jm0211218b00048\/jm0211218b00048_1","first-page":"924","volume":"21","author":"Kabsch W","year":"1988","journal-title":"J. Appl. Crystallogr."},{"key":"jm0211218b00049\/jm0211218b00049_1","first-page":"763","volume":"50","year":"1994","journal-title":"Acta Crystallogr., Sect. D"},{"key":"jm0211218b00050\/jm0211218b00050_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger A. T.","year":"1998","journal-title":"Acta Crystallogr., Sect. D"},{"key":"jm0211218b00051\/jm0211218b00051_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1432-1033.1996.0051r.x","volume":"242","author":"Feil C.","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"jm0211218b00052\/jm0211218b00052_1","volume-title":"Albert-Ludwigs-Universit\u00e4t, Freiburg im Breisgau","author":"Weihofen W. A.","year":"2001"},{"key":"jm0211218b00053\/jm0211218b00053_1","author":"Dehmlow H.","journal-title":"J. Med Chem., in press."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm0211218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T14:36:40Z","timestamp":1633531000000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm0211218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,30]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2003,5,1]]}},"alternative-id":["10.1021\/jm0211218"],"URL":"https:\/\/doi.org\/10.1021\/jm0211218","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,30]]}}}