{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:58:19Z","timestamp":1773316699090,"version":"3.50.1"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2003,7,1]]},"DOI":"10.1021\/jm030020m","type":"journal-article","created":{"date-parts":[[2003,6,26]],"date-time":"2003-06-26T04:52:00Z","timestamp":1056603120000},"page":"3060-3071","source":"Crossref","is-referenced-by-count":38,"title":["Novel Potent 5-HT<sub>1F<\/sub> Receptor Agonists:\u2009 Structure\u2212Activity Studies of a Series of Substituted <i>N<\/i>-[3-(1-Methyl-4-piperidinyl)-1<i>H<\/i>-pyrrolo[3,2-<i>b<\/i>]pyridin-5-yl]amides"],"prefix":"10.1021","volume":"46","author":[{"given":"Sandra A.","family":"Filla","sequence":"first","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Mathes","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee A.","family":"Phebus","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene L.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Zgombick","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon A.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn W.","family":"Schenck","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Wainscott","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa A.","family":"Branchek","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Schaus","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, and Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2003,6,3]]},"reference":[{"key":"jm030020mb00001\/jm030020mb00001_1","first-page":"651","volume":"47","author":"Plosker G. L.","year":"1994","journal-title":"Drugs"},{"key":"jm030020mb00002\/jm030020mb00002_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0165-6147(89)90238-1","volume":"10","author":"Saxena P. R.","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"jm030020mb00002\/jm030020mb00002_2","first-page":"1132","volume":"94","author":"Humphrey P. P. A.","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"jm030020mb00003\/jm030020mb00003_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/01.CIR.87.2.401","volume":"87","author":"MacIntyre P. D.","year":"1993","journal-title":"Circulation"},{"key":"jm030020mb00004\/jm030020mb00004_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2165\/00023210-199503020-00002","volume":"3","author":"Ottervanger J. P.","year":"1995","journal-title":"CNS Drugs"},{"key":"jm030020mb00004\/jm030020mb00004_2","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/0140-6736(93)90700-Q","volume":"341","author":"Hillis W. S.","year":"1993","journal-title":"Lancet"},{"key":"jm030020mb00004\/jm030020mb00004_3","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/0140-6736(93)92449-4","volume":"341","author":"Luman W.","year":"1993","journal-title":"Lancet"},{"key":"jm030020mb00005\/jm030020mb00005_1","first-page":"410","volume":"14","author":"Humphrey P. P. A.","year":"1994","journal-title":"Cephalalgia"},{"key":"jm030020mb00005\/jm030020mb00005_2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0165-6147(92)90097-P","volume":"13","author":"Moskowitz M. A","year":"1992","journal-title":"Trends Pharmacol. Sci."},{"key":"jm030020mb00006\/jm030020mb00006_1","first-page":"317","volume":"40","author":"Buzzi M. G.","year":"1992","journal-title":"Pathol. Biol."},{"key":"jm030020mb00007\/jm030020mb00007_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1468-2982.1995.1504277.x","volume":"15","author":"Buzzi M. G.","year":"1995","journal-title":"Cephalalgia"},{"key":"jm030020mb00007\/jm030020mb00007_2","unstructured":"(b) Moskowitz, M. A.; Cutrer, F. M.; Lee, W. S.; Waeber, C.; Limmroth, V.; Yu, X. Drug Discovery in Migraine Circa 1995. InExperimental Headache Models; Olesen, J., Moskowitz, M. A., Eds.; Lippincott-Raven Publishers:\u2009 Philadelphia, PA, 1995; pp 63\u221273."},{"key":"jm030020mb00008\/jm030020mb00008_1","first-page":"103","volume-title":"Migraine and Headache Pathophysiology","author":"Hargreaves R. J.","year":"1999"},{"key":"jm030020mb00008\/jm030020mb00008_2","first-page":"1237","volume":"121","author":"May A.","year":"1998","journal-title":"Brain"},{"key":"jm030020mb00008\/jm030020mb00008_3","first-page":"378","volume":"67","author":"May A.","year":"1996","journal-title":"Pain"},{"key":"jm030020mb00009\/jm030020mb00009_1","volume-title":"LY334370, and classical migraine abortives such as dihydroergotamine, inhibit neurogenic dural inflammation following electrical stimulation. (a) Johnson, K. W.","author":"Compounds","year":"1997"},{"key":"jm030020mb00010\/jm030020mb00010_1","first-page":"939","volume":"290","author":"Cohen M. L.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm030020mb00011\/jm030020mb00011_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1046\/j.1468-2982.1997.1706631.x","volume":"17","author":"Cohen M. L.","year":"1997","journal-title":"Cephalalgia"},{"key":"jm030020mb00012\/jm030020mb00012_1","first-page":"223","volume":"50","author":"Bouchelet I.","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"jm030020mb00012\/jm030020mb00012_2","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/sj.bjp.0701929","volume":"124","author":"Verheggen R.","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"jm030020mb00012\/jm030020mb00012_3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/sj.bjp.0702572","volume":"127","author":"De Vries P.","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"jm030020mb00013\/jm030020mb00013_1","first-page":"4034","volume":"44","author":"Xu Y.-C.","year":"2001","journal-title":"J. Med. Chem."},{"key":"jm030020mb00013\/jm030020mb00013_2","volume-title":"8th Congress of the International Headache Society","author":"Schaus J. M.","year":"1997"},{"key":"jm030020mb00014\/jm030020mb00014_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.bjp.0701832","volume":"124","author":"Dupuis D. S.","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"jm030020mb00014\/jm030020mb00014_2","volume-title":"26th Annual Meeting of the Society for Neuroscience","author":"Overshiner C. D.","year":"1996"},{"key":"jm030020mb00015\/jm030020mb00015_1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1046\/j.1468-2982.1999.1910851.x","volume":"19","author":"Shepheard S.","year":"1999","journal-title":"Cephalalgia"},{"key":"jm030020mb00016\/jm030020mb00016_1","first-page":"318","volume":"19","author":"Goldstein D. J.","year":"1999","journal-title":"Celphalalgia"},{"key":"jm030020mb00016\/jm030020mb00016_2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0140-6736(01)06347-4","volume":"358","author":"Goldstein D. J.","year":"2001","journal-title":"Lancet"},{"key":"jm030020mb00017\/jm030020mb00017_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1021\/ja01193a016","volume":"69","author":"Parker E. D.","year":"1947","journal-title":"J. Am. Chem. Soc."},{"key":"jm030020mb00018\/jm030020mb00018_1","first-page":"7952","volume":"60","author":"Taylor E. C.","year":"1995","journal-title":"J. Org. Chem."},{"key":"jm030020mb00019\/jm030020mb00019_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1073\/pnas.90.2.408","volume":"90","author":"Adham N.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm030020mb00020\/jm030020mb00020_1","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1073\/pnas.89.8.3630","volume":"89","author":"Weinshank R. L.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm030020mb00021\/jm030020mb00021_1","first-page":"1042","volume":"40","author":"Zgombick J. M.","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"jm030020mb00022\/jm030020mb00022_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0014-2999(98)00336-7","volume":"352","author":"Wainscott D. B.","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"jm030020mb00023\/jm030020mb00023_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0165-0270(98)00010-7","volume":"81","author":"Johnson K. W.","year":"1998","journal-title":"J. Neurosci. Methods"},{"key":"jm030020mb00024\/jm030020mb00024_1","first-page":"467","volume":"11","author":"MacroModel","year":"1990","journal-title":"J. Comput. Chem."},{"key":"jm030020mb00025\/jm030020mb00025_1","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1021\/ja00172a038","volume":"112","author":"Still W. C.","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"jm030020mb00027\/jm030020mb00027_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1476-5381.1996.tb15188.x","volume":"117","author":"Verheggen R.","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"jm030020mb00027\/jm030020mb00027_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1365-2125.1999.00851.x","volume":"47","author":"Razzaque Z.","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"jm030020mb00028\/jm030020mb00028_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0333102497017S2007","volume":"17","author":"Dahl\u00f6f C","year":"1997","journal-title":"Cephalalgia"},{"key":"jm030020mb00029\/jm030020mb00029_1","first-page":"6","volume":"8","author":"Headache Classification","year":"1988","journal-title":"Cephalalgia"},{"key":"jm030020mb00030\/jm030020mb00030_1","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1021\/ja01135a033","volume":"74","author":"Baumgarten H. E.","year":"1952","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm030020m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T16:19:33Z","timestamp":1633623573000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm030020m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,3]]},"references-count":42,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2003,7,1]]}},"alternative-id":["10.1021\/jm030020m"],"URL":"https:\/\/doi.org\/10.1021\/jm030020m","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,3]]}}}