{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:13:06Z","timestamp":1778209986529,"version":"3.51.4"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2003,11,1]]},"DOI":"10.1021\/jm030817d","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T17:28:21Z","timestamp":1180546101000},"page":"4952-4964","source":"Crossref","is-referenced-by-count":72,"title":["Design and Synthesis of<i>trans<\/i>-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1<i>H<\/i>-3-benzazepine (SB-414796):\u2009 A Potent and Selective Dopamine D<sub>3<\/sub>Receptor Antagonist"],"prefix":"10.1021","volume":"46","author":[{"given":"Gregor J.","family":"Macdonald","sequence":"first","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive L.","family":"Branch","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Hadley","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Nash","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander B.","family":"Smith","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Stemp","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Thewlis","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio K. K.","family":"Vong","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel E.","family":"Austin","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Jeffrey","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Y.","family":"Winborn","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izzy","family":"Boyfield","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim J.","family":"Hagan","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek N.","family":"Middlemiss","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie","family":"Reavill","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham J.","family":"Riley","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette M.","family":"Watson","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyn","family":"Wood","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve G.","family":"Parker","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Ashby","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK, and Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2003,10,15]]},"reference":[{"key":"jm030817db00001\/jm030817db00001_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00002826-199308000-00002","volume":"16","author":"Schwartz J. C.","year":"1993","journal-title":"Clin. Neuropharmacol."},{"key":"jm030817db00002\/jm030817db00002_1","first-page":"401","volume":"4","author":"Moller H. J.","year":"1997","journal-title":"Psychopharmacology"},{"key":"jm030817db00003\/jm030817db00003_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/347146a0","volume":"347","author":"Sokoloff P.","year":"1990","journal-title":"Nature"},{"key":"jm030817db00004\/jm030817db00004_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s002130050479","volume":"135","author":"Shafer R. A.","year":"1998","journal-title":"Psychopharmacology"},{"key":"jm030817db00005\/jm030817db00005_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0893-133X(96)00276-X","volume":"16","author":"Joyce J. N.","year":"1997","journal-title":"Neuropsychopharmacology"},{"key":"jm030817db00006\/jm030817db00006_1","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1021\/jm000090i","volume":"43","author":"Stemp G.","year":"2000","journal-title":"J. Med. Chem."},{"key":"jm030817db00007\/jm030817db00007_1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0022-3565(24)39184-0","volume":"294","author":"Reavill C.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm030817db00008\/jm030817db00008_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.6136093","volume":"221","author":"White F. J.","year":"1983","journal-title":"Science"},{"key":"jm030817db00009\/jm030817db00009_1","first-page":"1174","volume":"294","author":"Ashby C. R.","year":"2000","journal-title":"J. Pharmocol. Exp. Ther."},{"key":"jm030817db00010\/jm030817db00010_1","unstructured":"Gardner, E. L. Brain Reward Mechanisms.Substance Abuse:\u2009 AComprehensive Textbook, 3rd ed.; Williams & Wilkins:\u2009 Baltimore, pp 51\u221285."},{"key":"jm030817db00011\/jm030817db00011_1","first-page":"225","volume":"40","author":"Wise R. A.","year":"1989","journal-title":"Annu. Rev. Psychol."},{"key":"jm030817db00012\/jm030817db00012_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/22560","volume":"400","author":"Pilla M.","year":"1999","journal-title":"Nature"},{"key":"jm030817db00013\/jm030817db00013_1","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1523\/JNEUROSCI.22-21-09595.2002","volume":"22","author":"Vorel S. R.","year":"2002","journal-title":"J. Neurosci."},{"issue":"8","key":"jm030817db00015\/jm030817db00015_1","first-page":"686","volume":"31","author":"Austin N. E.","year":"2001","journal-title":"Xenobiotica"},{"key":"jm030817db00016\/jm030817db00016_1","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/S0960-894X(99)00312-1","volume":"9","author":"Dubuffet T.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00017\/jm030817db00017_1","first-page":"222","volume":"5","author":"Murray P. J.","year":"1995","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00018\/jm030817db00018_1","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/S0960-894X(97)00443-5","volume":"7","author":"Belliotti T. R.","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00019\/jm030817db00019_1","first-page":"2718","volume":"8","author":"Yuan J.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00020\/jm030817db00020_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0960-894X(97)00045-0","volume":"7","author":"Bolton D.","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00021\/jm030817db00021_1","first-page":"1998","volume":"7","author":"Boyfield I.","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00022\/jm030817db00022_1","volume-title":"Patent WO 0042036","author":"Starck D.","year":"2000"},{"key":"jm030817db00023\/jm030817db00023_1","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1021\/jm010145w","volume":"44","author":"Haadsma-Svensson S. R.","year":"2001","journal-title":"J. Med. Chem."},{"key":"jm030817db00024\/jm030817db00024_1","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/S0960-894X(00)00505-9","volume":"10","author":"Austin N. E.","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00025\/jm030817db00025_1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0960-894X(01)00037-3","volume":"11","author":"Austin N. E.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030817db00026\/jm030817db00026_1","volume-title":"Patent WO 00\/21951","author":"Hadley M. S.","year":"2000"},{"key":"jm030817db00027\/jm030817db00027_1","first-page":"1144","volume":"127","author":"Coldwell M. C.","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"jm030817db00028\/jm030817db00028_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1098-2396(199810)30:2<119::AID-SYN1>3.0.CO;2-F","volume":"30","author":"Dewey S. L.","year":"1998","journal-title":"Synapse"},{"key":"jm030817db00029\/jm030817db00029_3","volume-title":"J. C."},{"key":"jm030817db00029\/jm030817db00029_4","volume-title":"R."},{"key":"jm030817db00029\/jm030817db00029_5","volume-title":"J. C."},{"key":"jm030817db00030\/jm030817db00030_1","first-page":"927","volume":"25","author":"Bloomer J. C.","year":"1985","journal-title":"Xenobiotica"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm030817d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T20:02:03Z","timestamp":1737057723000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm030817d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,15]]},"references-count":31,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2003,11,1]]}},"alternative-id":["10.1021\/jm030817d"],"URL":"https:\/\/doi.org\/10.1021\/jm030817d","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,15]]}}}