{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:44:12Z","timestamp":1791902652503,"version":"4.3.4"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1021\/jm030912m","type":"journal-article","created":{"date-parts":[[2004,1,22]],"date-time":"2004-01-22T11:09:25Z","timestamp":1074769765000},"page":"550-557","source":"Crossref","is-referenced-by-count":408,"title":["Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib:\u2009 New Pharmacological Opportunities Due to Related Binding Site Recognition"],"prefix":"10.1021","volume":"47","author":[{"given":"Alexander","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Casini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Heine","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Klebe","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, D-35032 Marburg, Germany and Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia, 3, Rm. 188, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2003,12,18]]},"reference":[{"key":"jm030912mb00001\/jm030912mb00001_1","first-page":"120","volume":"38","author":"Vane J. R.","year":"1998","journal-title":"Annu Rev. Pharmacol. Toxicol."},{"key":"jm030912mb00002\/jm030912mb00002_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1172\/JCI200113455","volume":"108","author":"Narumiya S.","year":"2001","journal-title":"J. Clin. Invest."},{"key":"jm030912mb00003\/jm030912mb00003_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1172\/JCI200113416","volume":"108","author":"Tilley S. L.","year":"2001","journal-title":"J. Clin. Invest."},{"key":"jm030912mb00004\/jm030912mb00004_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1073\/pnas.96.1.272","volume":"96","author":"McAdam B. F.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"jm030912mb00005\/jm030912mb00005_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1152\/ajprenal.2001.281.1.F1","volume":"281","author":"Harris R. C.","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"jm030912mb00006\/jm030912mb00006_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1172\/JCI6899","volume":"105","author":"Morteau O.","year":"2000","journal-title":"J. Clin. Invest."},{"key":"jm030912mb00007\/jm030912mb00007_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1073\/pnas.96.1.8","volume":"96","author":"Warner T. D.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"jm030912mb00008\/jm030912mb00008_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1172\/JCI114850","volume":"86","author":"Masferrer J. L.","year":"1990","journal-title":"J. Clin. Invest."},{"key":"jm030912mb00009\/jm030912mb00009_1","first-page":"60","volume":"290","author":"Chan C. C.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm030912mb00010\/jm030912mb00010_1","first-page":"75","volume":"283","author":"Zhang Y.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm030912mb00011\/jm030912mb00011_1","volume-title":"JAMA 1999","author":"Simon L. S.","year":"1921"},{"key":"jm030912mb00012\/jm030912mb00012_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/1529-0131(200002)43:2<370::AID-ANR17>3.0.CO;2-D","volume":"43","author":"Hawkey C.","year":"2000","journal-title":"Arthritis Rheum."},{"key":"jm030912mb00013\/jm030912mb00013_1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM200011233432103","volume":"343","author":"Bombardier C.","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"jm030912mb00014\/jm030912mb00014_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/jama.284.10.1247","volume":"284","author":"Silverstein F. E.","year":"2000","journal-title":"JAMA"},{"key":"jm030912mb00015\/jm030912mb00015_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1056\/NEJM200108093450607","volume":"345","author":"FitzGerald G. A.","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"jm030912mb00016\/jm030912mb00016_1","doi-asserted-by":"crossref","first-page":"33S","DOI":"10.1016\/S0002-9343(00)00699-9","volume":"110","author":"Whelton A","year":"2001","journal-title":"Am J Med"},{"key":"jm030912mb00017\/jm030912mb00017_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00045391-200103000-00003","volume":"8","author":"Whelton A.","year":"2001","journal-title":"Am. J. Ther."},{"key":"jm030912mb00018\/jm030912mb00018_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0002-9149(02)02661-9","volume":"90","author":"Whelton A.","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"jm030912mb00019\/jm030912mb00019_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/med.10023","volume":"23","author":"Supuran C. T.","year":"2003","journal-title":"Med. Res. Rev."},{"key":"jm030912mb00020\/jm030912mb00020_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1517\/13543776.10.5.575","volume":"10","author":"Supuran C. T.","year":"2000","journal-title":"Expert Opin. Ther. Pat."},{"key":"jm030912mb00021\/jm030912mb00021_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1021\/jm011131t","volume":"45","author":"Abbate F.","year":"2002","journal-title":"J. Med. Chem."},{"key":"jm030912mb00022\/jm030912mb00022_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/384644a0","volume":"384","author":"Kurumbail R. G.","year":"1996","journal-title":"Nature"},{"key":"jm030912mb00023\/jm030912mb00023_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/pro.5560030115","volume":"3","author":"Smith G. M.","year":"1994","journal-title":"Protein Sci."},{"key":"jm030912mb00024\/jm030912mb00024_1","first-page":"88","volume":"9","author":"Pastorek J.","year":"1994","journal-title":"Oncogene"},{"key":"jm030912mb00025\/jm030912mb00025_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0960-894X(03)00091-X","volume":"13","author":"Vullo D.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm030912mb00026\/jm030912mb00026_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0163-7258(96)00198-2","volume":"74","author":"Lindskog S","year":"1997","journal-title":"Pharmacol. Ther."},{"key":"jm030912mb00027\/jm030912mb00027_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1432-1033.1994.tb19909.x","volume":"219","author":"Liljas A.","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"jm030912mb00028\/jm030912mb00028_1","first-page":"4","volume":"40","author":"Schmitt S.","year":"2001","journal-title":"Angew. Chem., Int. Ed."},{"key":"jm030912mb00029\/jm030912mb00029_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0022-2836(02)00811-2","volume":"323","author":"Schmitt S.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"jm030912mb00030\/jm030912mb00030_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrd1034","volume":"2","author":"Flower R. J.","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"jm030912mb00031\/jm030912mb00031_1","first-page":"9","volume":"7","author":"Boriack-Sjodin P. A.","year":"1998","journal-title":"Protein Sci."},{"key":"jm030912mb00032\/jm030912mb00032_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/1521-3773(20011119)40:22<4175::AID-ANIE4175>3.0.CO;2-#","volume":"40","author":"Folkers G.","year":"2001","journal-title":"Angew. Chem., Int. Ed."},{"key":"jm030912mb00033\/jm030912mb00033_1","first-page":"12","volume":"58","author":"Kawamori T.","year":"1998","journal-title":"Cancer Res."},{"key":"jm030912mb00034\/jm030912mb00034_1","first-page":"40","volume":"61","author":"Oshima M.","year":"2001","journal-title":"Cancer Res."},{"key":"jm030912mb00035\/jm030912mb00035_1","first-page":"33","volume":"62","author":"Waskewich C.","year":"2002","journal-title":"Cancer Res."},{"key":"jm030912mb00036\/jm030912mb00036_1","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1073\/pnas.1733826100","volume":"100","author":"Warner T. D.","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"jm030912mb00037\/jm030912mb00037_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0076-6879(97)76067-1","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"jm030912mb00038\/jm030912mb00038_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger A. T.","year":"1998","journal-title":"Acta Crystallogr. D"},{"key":"jm030912mb00039\/jm030912mb00039_1","first-page":"343","volume":"277","author":"Sheldrick G. M.","year":"1997","journal-title":"Methods Enzymol."},{"key":"jm030912mb00040\/jm030912mb00040_1","first-page":"9","volume":"47","author":"Jones T. A.","year":"1991","journal-title":"Acta Crystallogr. A"},{"key":"jm030912mb00041\/jm030912mb00041_1","volume-title":"The PyMOL Molecular Graphics System","author":"DeLano W. L.","year":"2002"},{"key":"jm030912mb00042\/jm030912mb00042_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0014-5793(94)00798-5","volume":"350","author":"Hakansson K.","year":"1994","journal-title":"FEBS Lett."},{"key":"jm030912mb00043\/jm030912mb00043_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm030912m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T22:56:22Z","timestamp":1633474582000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm030912m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,18]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,1,1]]}},"alternative-id":["10.1021\/jm030912m"],"URL":"https:\/\/doi.org\/10.1021\/jm030912m","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,18]]}}}