{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:44:42Z","timestamp":1791168282155,"version":"4.1.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1021\/jm049782n","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T06:40:32Z","timestamp":1100155232000},"page":"5945-5952","source":"Crossref","is-referenced-by-count":143,"title":["Design, Synthesis, and Biological Evaluation of Conformationally Restricted Rivastigmine Analogues"],"prefix":"10.1021","volume":"47","author":[{"given":"Maria Laura","family":"Bolognesi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Andrisano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Rosini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Minarini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Melchiorre","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2004,10,14]]},"reference":[{"key":"jm049782nb00001\/jm049782nb00001_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1126\/science.1072994","volume":"297","author":"Hardy J.","year":"2002","journal-title":"Science"},{"key":"jm049782nb00002\/jm049782nb00002_1","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1073\/pnas.97.12.6826","volume":"97","author":"Capsoni S.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm049782nb00003\/jm049782nb00003_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1006\/exnr.2000.7397","volume":"163","author":"Bartus R. T","year":"2000","journal-title":"Exp. Neurol."},{"key":"jm049782nb00004\/jm049782nb00004_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1124\/jpet.102.041616","volume":"306","author":"Terry A. V.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm049782nb00005\/jm049782nb00005_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0140-6736(95)90526-X","volume":"345","author":"Davis K. L.","year":"1995","journal-title":"Lancet"},{"key":"jm049782nb00006\/jm049782nb00006_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2165\/00002512-199710030-00007","volume":"10","author":"Bryson H. M.","year":"1997","journal-title":"Drugs Aging"},{"key":"jm049782nb00007\/jm049782nb00007_1","first-page":"2402","volume":"9","author":"Sramek J. J.","year":"2000","journal-title":"Expert Opin. Invest. Drugs"},{"key":"jm049782nb00008\/jm049782nb00008_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1385\/JMN:20:3:349","volume":"20","author":"Fisher A.","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"jm049782nb00009\/jm049782nb00009_1","first-page":"1682","volume":"8","author":"Gottwald M. D.","year":"1999","journal-title":"Expert Opin. Invest. Drugs"},{"key":"jm049782nb00010\/jm049782nb00010_1","doi-asserted-by":"crossref","unstructured":"Weinstock, M.; Razin, M.; Chorev, M.; Tashma, Z.Advances inBehavioral Biology; Plenum Press:\u2009 New York, 1986; pp 539\u2212551.","DOI":"10.1007\/978-1-4613-2179-8_61"},{"key":"jm049782nb00011\/jm049782nb00011_1","first-page":"1653","volume":"25","author":"Williams B. R.","year":"2003","journal-title":"Clin. Ther."},{"key":"jm049782nb00012\/jm049782nb00012_1","first-page":"438","volume":"98","author":"Enz A.","year":"1993","journal-title":"Prog. Brain Res."},{"key":"jm049782nb00013\/jm049782nb00013_1","first-page":"214","volume":"56","author":"Bullock R","year":"2002","journal-title":"Int. J. Clin. Pract."},{"key":"jm049782nb00014\/jm049782nb00014_1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s007020200089","volume":"109","author":"Giacobini E.","year":"2002","journal-title":"J. Neural Transm."},{"key":"jm049782nb00015\/jm049782nb00015_1","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1021\/bi020016x","volume":"41","author":"Bar-On P.","year":"2002","journal-title":"Biochemistry"},{"key":"jm049782nb00016\/jm049782nb00016_1","first-page":"109","volume":"44","author":"Bolognesi M. L.","year":"2001","journal-title":"J. Med. Chem."},{"key":"jm049782nb00017\/jm049782nb00017_1","first-page":"7218","volume":"68","author":"Hanessian S.","year":"2003","journal-title":"J. Org. Chem."},{"key":"jm049782nb00018\/jm049782nb00018_1","volume-title":"Patent 4,173,633","author":"Gruenfeld N.","year":"1979"},{"key":"jm049782nb00019\/jm049782nb00019_1","first-page":"2978","volume":"12","author":"Rahaman L. K. A.","year":"1983","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"jm049782nb00020\/jm049782nb00020_1","first-page":"3579","volume":"3573","author":"Yaouancq L.","year":"2002","journal-title":"Eur. J. Org. Chem."},{"key":"jm049782nb00021\/jm049782nb00021_1","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1021\/jm020120c","volume":"45","author":"Sterling J.","year":"2002","journal-title":"J. Med. Chem."},{"key":"jm049782nb00022\/jm049782nb00022_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman G. L.","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"jm049782nb00023\/jm049782nb00023_1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0006-2952(02)01514-9","volume":"65","author":"Bartolini M.","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"jm049782nb00024\/jm049782nb00024_1","first-page":"225","volume":"43","author":"Weinstock M.","year":"1994","journal-title":"J. Neural Transm., Suppl."},{"key":"jm049782nb00025\/jm049782nb00025_1","first-page":"223","volume":"5","author":"Lieske C. N.","year":"1991","journal-title":"J. Enzyme Inhib."},{"key":"jm049782nb00026\/jm049782nb00026_1","doi-asserted-by":"crossref","first-page":"41147","DOI":"10.1074\/jbc.M210241200","volume":"278","author":"Nicolet Y.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"jm049782nb00027\/jm049782nb00027_1","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1021\/bi9716579","volume":"37","author":"Yuan T.","year":"1998","journal-title":"Biochemistry"},{"key":"jm049782nb00028\/jm049782nb00028_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0896-6273(00)80108-7","volume":"16","author":"Inestrosa N. C.","year":"1996","journal-title":"Neuron"},{"key":"jm049782nb00029\/jm049782nb00029_1","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1021\/jm0340602","volume":"46","author":"Piazzi L.","year":"2003","journal-title":"J. Med. Chem."},{"key":"jm049782nb00030\/jm049782nb00030_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/(SICI)1099-1344(199708)39:8<651::AID-JLCR14>3.0.CO;2-8","volume":"39","author":"Ciszewska G.","year":"1997","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"jm049782nb00031\/jm049782nb00031_1","first-page":"110","volume":"65","author":"Naiki H.","year":"1991","journal-title":"Lab. Invest."},{"key":"jm049782nb00032\/jm049782nb00032_1","first-page":"284","volume":"309","author":"LeVine H.","year":"1999","journal-title":"Methods Enzymol."},{"key":"jm049782nb00033\/jm049782nb00033_1","doi-asserted-by":"crossref","first-page":"23287","DOI":"10.1074\/jbc.M009596200","volume":"276","author":"De Ferrari G. V.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"jm049782nb00034\/jm049782nb00034_1","first-page":"220","volume":"10","author":"Stewart J. P. P","year":"1989","journal-title":"J. Comput. Chem."},{"key":"jm049782nb00035\/jm049782nb00035_1","first-page":"4386","volume":"111","author":"Chang G.","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"jm049782nb00036\/jm049782nb00036_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jcc.540110405","volume":"11","author":"Mohamadi F.","year":"1990","journal-title":"J. Comput. Chem."},{"key":"jm049782nb00037\/jm049782nb00037_1","first-page":"519","volume":"17","author":"Halgren T. A","year":"1996","journal-title":"J. Comput. Chem."},{"key":"jm049782nb00038\/jm049782nb00038_1","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1021\/ja00172a038","volume":"112","author":"Still W. C.","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"jm049782nb00039\/jm049782nb00039_1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/jcc.540150811","volume":"15","author":"Shenkin P. S.","year":"1994","journal-title":"J. Comput. Chem."},{"key":"jm049782nb00040\/jm049782nb00040_1","first-page":"3853","volume":"45","author":"Cavalli A.","year":"2002","journal-title":"J. Med. Chem."},{"key":"jm049782nb00041\/jm049782nb00041_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0022-2836(82)90153-X","volume":"161","author":"Kuntz I. D.","year":"1982","journal-title":"J. Mol. Biol."},{"key":"jm049782nb00042\/jm049782nb00042_1","volume-title":"Sect. D:\u2009 Biol. Crystallogr.","author":"Kryger G.","year":"2000"},{"key":"jm049782nb00043\/jm049782nb00043_1","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1021\/ja00124a002","volume":"117","author":"Cornell W. D.","year":"1995","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm049782n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T17:24:34Z","timestamp":1679678674000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm049782n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,14]]},"references-count":43,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2004,11,1]]}},"alternative-id":["10.1021\/jm049782n"],"URL":"https:\/\/doi.org\/10.1021\/jm049782n","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,14]]}}}