{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:30Z","timestamp":1791348150939,"version":"4.3.1"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2005,7,1]]},"DOI":"10.1021\/jm0501073","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T11:49:38Z","timestamp":1121946578000},"page":"4834-4841","source":"Crossref","is-referenced-by-count":202,"title":["Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors"],"prefix":"10.1021","volume":"48","author":[{"given":"Alessandro","family":"Cecchi","sequence":"first","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzbeta","family":"Hulikova","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarom\u00edr","family":"Pastorek","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pastorekov\u00e1","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Montero","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy, Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 05 Bratislava, Slovak Republic, and Laboratoire de Chimie Biomol\u00e9culaire, FRE 5032, Ecole Nationale Sup\u00e9rieure de Chimie de Montpellier, Universit\u00e9 Montpellier II, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,7,6]]},"reference":[{"key":"jm0501073b00001\/jm0501073b00001_1","first-page":"189","volume":"23","author":"Supuran C. T.","year":"2003","journal-title":"Med. Res. Rev."},{"key":"jm0501073b00001\/jm0501073b00001_2","doi-asserted-by":"crossref","unstructured":"(b) Supuran, C. T., Scozzafava, A., Conway, J., Eds.Carbonic AnhydraseIts Inhibitors and Activators; CRC Press (Taylor and Francis Group):\u2009 Boca Raton, FL, 2004; pp 1\u2212363 and references therein.","DOI":"10.1201\/9780203475300"},{"key":"jm0501073b00001\/jm0501073b00001_3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1568009023334060","volume":"2","author":"Casini A.","year":"2002","journal-title":"Curr. Cancer Drug Targets"},{"key":"jm0501073b00002\/jm0501073b00002_1","first-page":"280","volume-title":"Carbonic AnhydraseIts Inhibitors and Activators","author":"Pastorekova S.","year":"2004"},{"key":"jm0501073b00002\/jm0501073b00002_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova S.","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"jm0501073b00002\/jm0501073b00002_3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2174\/0929867033457647","volume":"10","author":"Scozzafava A.","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"jm0501073b00003\/jm0501073b00003_1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1073\/pnas.040554897","volume":"97","author":"Parkkila S.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm0501073b00003\/jm0501073b00003_2","first-page":"1556","volume":"13","author":"Teicher B. A.","year":"1993","journal-title":"Anticancer Res."},{"key":"jm0501073b00004\/jm0501073b00004_1","first-page":"874","volume":"35","author":"Supuran C. T.","year":"2000","journal-title":"J. Med. Chem."},{"key":"jm0501073b00004\/jm0501073b00004_2","first-page":"610","volume":"15","author":"Supuran C. T.","year":"2000","journal-title":"J. Enzyme Inhib."},{"key":"jm0501073b00005\/jm0501073b00005_1","first-page":"1120","volume":"10","author":"Scozzafava A.","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0501073b00005\/jm0501073b00005_2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0968-0896(00)00288-1","volume":"9","author":"Supuran C. T.","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"jm0501073b00006\/jm0501073b00006_1","first-page":"2888","volume":"9","author":"Pastorek J.","year":"1994","journal-title":"Oncogene"},{"key":"jm0501073b00006\/jm0501073b00006_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/geno.1996.0223","volume":"33","author":"Opavsk\u00fd R.","year":"1996","journal-title":"Genomics"},{"key":"jm0501073b00007\/jm0501073b00007_1","first-page":"7613","volume":"95","author":"Tureci O.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm0501073b00008\/jm0501073b00008_1","first-page":"7083","volume":"60","author":"Wykoff C. C.","year":"2000","journal-title":"Cancer Res."},{"key":"jm0501073b00009\/jm0501073b00009_1","first-page":"7","volume":"89","author":"Potter C. P. S.","year":"2003","journal-title":"Br. J. Cancer"},{"key":"jm0501073b00010\/jm0501073b00010_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0014-4827(03)00351-3","volume":"290","author":"Svastova E.","year":"2003","journal-title":"Exp. Cell Res."},{"key":"jm0501073b00011\/jm0501073b00011_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova E.","year":"2004","journal-title":"FEBS Lett."},{"key":"jm0501073b00012\/jm0501073b00012_1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc1187","volume":"3","author":"Semenza G. L","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"jm0501073b00013\/jm0501073b00013_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1357-4310(99)01615-9","volume":"6","author":"Stubbs M.","year":"2000","journal-title":"Mol. Med. Today"},{"key":"jm0501073b00013\/jm0501073b00013_2","first-page":"1291","volume":"8","author":"Helmlinger G.","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"jm0501073b00014\/jm0501073b00014_1","first-page":"6024","volume":"61","author":"Fukumura D.","year":"2001","journal-title":"Cancer Res."},{"key":"jm0501073b00014\/jm0501073b00014_2","first-page":"11430","volume":"267","author":"Kato Y.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"jm0501073b00015\/jm0501073b00015_1","first-page":"186","volume":"14","author":"Martinez-Zaguilan R.","year":"1992","journal-title":"Clin. Exp. Metastasis"},{"key":"jm0501073b00016\/jm0501073b00016_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/clim.2000.4904","volume":"96","author":"Fischer B.","year":"2000","journal-title":"Clin. Immunol."},{"key":"jm0501073b00017\/jm0501073b00017_1","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1021\/jm001051+","volume":"43","author":"Casini A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"jm0501073b00017\/jm0501073b00017_2","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1021\/jm049692i","volume":"47","author":"Innocenti A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm0501073b00018\/jm0501073b00018_1","first-page":"93","volume":"33","author":"Supuran C. T.","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"jm0501073b00019\/jm0501073b00019_1","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah R. G","year":"1971","journal-title":"J. Biol. Chem."},{"key":"jm0501073b00020\/jm0501073b00020_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/bmc.1130070305","volume":"7","author":"Gomaa Z. S","year":"1993","journal-title":"Biomed. Chromatogr."},{"key":"jm0501073b00021\/jm0501073b00021_1","first-page":"701","volume":"61","author":"Abdine H.","year":"1978","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"jm0501073b00022\/jm0501073b00022_1","first-page":"378","volume-title":"Carbonic AnhydraseFrom Biochemistry and Genetics to Physiology and Clinical Medicine","author":"Wistrand P. J.","year":"1991"},{"key":"jm0501073b00023\/jm0501073b00023_1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0960-894X(03)00091-X","volume":"13","author":"Vullo D.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0501073b00024\/jm0501073b00024_1","first-page":"300","volume":"43","author":"Scozzafava A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"jm0501073b00025\/jm0501073b00025_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bmcl.2003.12.029","volume":"14","author":"Pastorekova S.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0501073b00026\/jm0501073b00026_1","first-page":"223","volume":"14","author":"Abbate F.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0501073b00026\/jm0501073b00026_2","first-page":"557","volume":"47","author":"Weber A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm0501073b00027\/jm0501073b00027_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/1475636031000119337","volume":"18","author":"Abbate F.","year":"2003","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"jm0501073b00027\/jm0501073b00027_2","first-page":"2763","volume":"13","author":"Casini A.","year":"2003","journal-title":"Med. Chem. Lett."},{"key":"jm0501073b00027\/jm0501073b00027_3","first-page":"2361","volume":"14","author":"Abbate F.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0501073b00028\/jm0501073b00028_1","first-page":"273","volume":"19","author":"Supuran C. T.","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm0501073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T15:55:01Z","timestamp":1735833301000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm0501073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,1]]},"references-count":42,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2005,7,1]]}},"alternative-id":["10.1021\/jm0501073"],"URL":"https:\/\/doi.org\/10.1021\/jm0501073","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,1]]}}}