{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:36:23Z","timestamp":1760852183851},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2005,12,1]]},"DOI":"10.1021\/jm050377l","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T05:19:55Z","timestamp":1134019195000},"page":"8035-8044","source":"Crossref","is-referenced-by-count":12,"title":["Potent Dmt-Tic Pharmacophoric \u03b4- and \u03bc-Opioid Receptor Antagonists"],"prefix":"10.1021","volume":"48","author":[{"given":"Tingyou","family":"Li","sequence":"first","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Fujita","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimitaka","family":"Shiotani","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tsuda","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ambo","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sasaki","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunden","family":"Jinsmaa","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Marczak","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon D.","family":"Bryant","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severo","family":"Salvadori","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence H.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Okada","sequence":"additional","affiliation":[{"name":"The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, Ferrara 44100, Italy, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,11,3]]},"reference":[{"key":"jm050377lb00001\/jm050377lb00001_1","volume-title":"Bio. Chem.","year":"1985"},{"key":"jm050377lb00002\/jm050377lb00002_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1006\/bbrc.1994.1133","volume":"198","author":"Temussi P. A.","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"jm050377lb00003\/jm050377lb00003_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF03401608","volume":"1","author":"Salvadori S.","year":"1995","journal-title":"Mol. Med."},{"key":"jm050377lb00004\/jm050377lb00004_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0024-3205(96)00353-0","volume":"59","author":"Capasso A.","year":"1996","journal-title":"Life Sci."},{"key":"jm050377lb00005\/jm050377lb00005_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1359-6446(98)01187-8","volume":"3","author":"Lazarus L. H.","year":"1998","journal-title":"Drug Discovery Today"},{"key":"jm050377lb00005\/jm050377lb00005_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/bip.10399","volume":"71","author":"Bryant S. D.","year":"2003","journal-title":"Biopolymers (Pept. Sci.)"},{"key":"jm050377lb00006\/jm050377lb00006_1","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1021\/jm9607663","volume":"40","author":"Salvadori S.","year":"1997","journal-title":"J. Med. Chem."},{"key":"jm050377lb00006\/jm050377lb00006_2","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1021\/jm990165m","volume":"42","author":"Salvadori S.","year":"1999","journal-title":"J. Med. Chem."},{"key":"jm050377lb00007\/jm050377lb00007_1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0196-9781(00)00315-6","volume":"21","author":"Balboni G.","year":"2000","journal-title":"Peptides"},{"key":"jm050377lb00008\/jm050377lb00008_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0014-5793(97)01271-4","volume":"417","author":"Capasso A.","year":"1997","journal-title":"FEBS Lett."},{"key":"jm050377lb00009\/jm050377lb00009_1","first-page":"720","volume":"45","author":"Balboni G.","year":"2002","journal-title":"J. Med. Chem."},{"key":"jm050377lb00009\/jm050377lb00009_2","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1016\/j.bmc.2003.09.039","volume":"11","author":"Balboni G.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"jm050377lb00009\/jm050377lb00009_3","first-page":"6546","volume":"47","author":"Balboni G.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm050377lb00010\/jm050377lb00010_1","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1021\/jm020459z","volume":"46","author":"Okada Y.","year":"2003","journal-title":"J. Med. Chem."},{"key":"jm050377lb00011\/jm050377lb00011_1","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/jm0304616","volume":"47","author":"Jinsmaa Y.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm050377lb00012\/jm050377lb00012_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0741-8329(97)00131-6","volume":"15","author":"Stromberg M. F.","year":"1998","journal-title":"Alcohol"},{"key":"jm050377lb00013\/jm050377lb00013_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-6147(89)90267-8","volume":"10","author":"Portoghese P. S","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"jm050377lb00013\/jm050377lb00013_2","first-page":"1937","volume":"35","author":"Portoghese P. S","year":"1992","journal-title":"J. Med. Chem."},{"key":"jm050377lb00013\/jm050377lb00013_3","first-page":"2269","volume":"44","author":"Portoghese P. S","year":"2001","journal-title":"J. Med. Chem."},{"key":"jm050377lb00014\/jm050377lb00014_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0196-9781(82)90173-5","volume":"3","author":"Lipkowski A. W.","year":"1982","journal-title":"Peptides"},{"key":"jm050377lb00015\/jm050377lb00015_1","first-page":"362","volume":"264","author":"Lazarus L. H.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"jm050377lb00016\/jm050377lb00016_1","first-page":"54","volume":"265","author":"Horan P. J.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm050377lb00016\/jm050377lb00016_2","first-page":"156","volume-title":"Peptides:\u2009 Chemistry, Structure and Biology","author":"Hruby V. J.","year":"1996"},{"key":"jm050377lb00016\/jm050377lb00016_3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1046\/j.1471-4159.1997.69031236.x","volume":"69","author":"Abbruscato T. J.","year":"1997","journal-title":"J. Neurochem."},{"key":"jm050377lb00016\/jm050377lb00016_4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0024-3205(97)00069-6","volume":"60","author":"Misicka A.","year":"1997","journal-title":"Life Sci."},{"key":"jm050377lb00016\/jm050377lb00016_5","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0024-3205(01)01194-8","volume":"69","author":"Yamazaki M.","year":"2001","journal-title":"Life Sci."},{"key":"jm050377lb00017\/jm050377lb00017_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1399-3011.2003.00108.x","volume":"63","author":"Weltrowska G.","year":"2004","journal-title":"J. Pept. Res."},{"key":"jm050377lb00018\/jm050377lb00018_1","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/0024-3205(87)90585-6","volume":"40","author":"Portoghese P. S.","year":"1987","journal-title":"Life Sci."},{"key":"jm050377lb00018\/jm050377lb00018_2","first-page":"258","volume":"246","author":"Takimori A. E.","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm050377lb00019\/jm050377lb00019_1","first-page":"602","volume":"15","author":"Fujita Y.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm050377lb00020\/jm050377lb00020_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jchromb.2004.02.024","volume":"806","author":"Igarashi K.","year":"2004","journal-title":"J. Chromatography B"},{"key":"jm050377lb00021\/jm050377lb00021_1","first-page":"743","volume":"8","author":"Dygos J. H.","year":"1992","journal-title":"Synthesis"},{"key":"jm050377lb00022\/jm050377lb00022_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1021\/jm00122a017","volume":"32","author":"Callahan J. F.","year":"1989","journal-title":"J. Med. Chem."},{"key":"jm050377lb00023\/jm050377lb00023_1","doi-asserted-by":"crossref","first-page":"14406","DOI":"10.1016\/S0040-4020(99)00908-4","volume":"55","author":"Okada Y.","year":"1999","journal-title":"Tetrahedron"},{"key":"jm050377lb00024\/jm050377lb00024_1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1021\/jm030649p","volume":"47","author":"Fujita Y.","year":"2004","journal-title":"J. Med. Chem."},{"key":"jm050377lb00025\/jm050377lb00025_1","first-page":"551","volume":"249","author":"Kramer T. H.","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm050377lb00025\/jm050377lb00025_2","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1248\/cpb.50.1401","volume":"50","author":"Ambo A.","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"jm050377lb00026\/jm050377lb00026_1","first-page":"498","volume":"220","author":"Ward S. J.","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm050377lb00026\/jm050377lb00026_2","first-page":"1056","volume":"262","author":"Comer S. D.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm050377lb00026\/jm050377lb00026_3","first-page":"547","volume":"279","author":"Xu J. Y.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm050377lb00026\/jm050377lb00026_4","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1021\/jm0009641","volume":"43","author":"Derrick I.","year":"2000","journal-title":"J. Med. Chem."},{"key":"jm050377lb00027\/jm050377lb00027_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0168-0102(95)00933-K","volume":"23","author":"Minami M.","year":"1995","journal-title":"Neurosci. Res."},{"key":"jm050377lb00028\/jm050377lb00028_1","first-page":"408","volume-title":"Peptides 2000","author":"Bryant S. D.","year":"2001"},{"key":"jm050377lb00029\/jm050377lb00029_1","first-page":"21429","volume":"271","author":"Chen C.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"jm050377lb00030\/jm050377lb00030_1","first-page":"22804","volume":"278","author":"Marie N.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"jm050377lb00031\/jm050377lb00031_1","first-page":"74","volume":"222","author":"Shimohigashi Y.","year":"1987","journal-title":"FEBS Lett."},{"key":"jm050377lb00031\/jm050377lb00031_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0014-5793(88)80444-7","volume":"233","author":"Shimohigashi Y.","year":"1988","journal-title":"FEBS Lett."},{"key":"jm050377lb00031\/jm050377lb00031_3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(90)90556-L","volume":"177","author":"Vaughn L. K.","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"jm050377lb00032\/jm050377lb00032_1","first-page":"E10","volume":"259","author":"Banks W. A.","year":"1990","journal-title":"Am. J. Physiol."},{"key":"jm050377lb00033\/jm050377lb00033_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1021\/jm00108a017","volume":"34","author":"Lazarus L. H.","year":"1991","journal-title":"J. Med. Chem."},{"key":"jm050377lb00033\/jm050377lb00033_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0196-9781(93)90006-3","volume":"14","author":"Lazarus L. H.","year":"1993","journal-title":"Peptides"},{"key":"jm050377lb00034\/jm050377lb00034_1","first-page":"3108","volume":"22","author":"Cheng Y.-C.","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"jm050377lb00035\/jm050377lb00035_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0968-0896(02)00601-6","volume":"11","author":"Sasaki Y.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"jm050377lb00036\/jm050377lb00036_1","first-page":"58","volume":"14","author":"Arunlakshana Q.","year":"1959","journal-title":"Br. J. Pharmcol."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm050377l","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T15:12:51Z","timestamp":1706800371000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm050377l"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,3]]},"references-count":54,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2005,12,1]]}},"alternative-id":["10.1021\/jm050377l"],"URL":"https:\/\/doi.org\/10.1021\/jm050377l","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,3]]}}}