{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:37:40Z","timestamp":1769067460589,"version":"3.49.0"},"reference-count":16,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2006,2,1]]},"DOI":"10.1021\/jm0509795","type":"journal-article","created":{"date-parts":[[2006,2,2]],"date-time":"2006-02-02T05:28:01Z","timestamp":1138858081000},"page":"843-846","source":"Crossref","is-referenced-by-count":35,"title":["A Selective Estrogen Receptor Modulator for the Treatment of Hot Flushes"],"prefix":"10.1021","volume":"49","author":[{"given":"Owen B.","family":"Wallace","sequence":"first","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Lauwers","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Dodge","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"May","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel R.","family":"Calvin","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Hinklin","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry U.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela K.","family":"Shetler","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary D.","family":"Adrian","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Geiser","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Burris","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Array Biopharma, 2600 Trade Center Avenue, Longmont, Colorado 80503"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"jm0509795b00001\/jm0509795b00001_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00006842-196505000-00009","volume":"27","author":"Neugarten B. L.","year":"1965","journal-title":"Psychosom. Med."},{"key":"jm0509795b00002\/jm0509795b00002_1","first-page":"277","volume":"4","author":"Jaszmann L.","year":"1969","journal-title":"Med. Gynecol. Socio."},{"key":"jm0509795b00003\/jm0509795b00003_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1139\/y87-208","volume":"65","author":"Kronenberg F.","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"jm0509795b00004\/jm0509795b00004_1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.4065\/77.11.1207","volume":"77","author":"Shanafelt T. D.","year":"2002","journal-title":"Mayo Clin. Proc."},{"key":"jm0509795b00005\/jm0509795b00005_1","first-page":"1847","volume":"151","author":"Love R. R.","year":"1991","journal-title":"Arch. Intern. Med."},{"key":"jm0509795b00006\/jm0509795b00006_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/jbmr.5650110615","volume":"11","author":"Draper M. W.","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"jm0509795b00007\/jm0509795b00007_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/jama.280.7.605","volume":"280","author":"Hulley S.","year":"1998","journal-title":"J. Am. Med. Assoc."},{"key":"jm0509795b00008\/jm0509795b00008_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0378-5122(92)90249-4","volume":"15","author":"Coope J.","year":"1992","journal-title":"Maturitas"},{"key":"jm0509795b00009\/jm0509795b00009_1","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1021\/jm034134+","volume":"46","author":"Watanabe N.","year":"2003","journal-title":"J. Med. Chem."},{"key":"jm0509795b00010\/jm0509795b00010_1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/jm970688z","volume":"41","author":"Grese T. A.","year":"1998","journal-title":"J. Med. Chem."},{"key":"jm0509795b00011\/jm0509795b00011_1","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1002\/(SICI)1521-3773(19980817)37:15<1986::AID-ANIE1986>3.0.CO;2-Z","volume":"37","author":"Corey E. J.","year":"1998","journal-title":"Angew. Chem., Intl. Ed."},{"key":"jm0509795b00013\/jm0509795b00013_1","first-page":"1910","volume":"13","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0509795b00014\/jm0509795b00014_1","first-page":"5106","volume":"14","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm0509795b00015\/jm0509795b00015_1","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1073\/pnas.74.8.3162","volume":"74","author":"Lyttle C. R.","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm0509795b00016\/jm0509795b00016_1","first-page":"3922","volume":"36","author":"Kym P. R.","year":"1993","journal-title":"J. Med. Chem."},{"key":"jm0509795b00017\/jm0509795b00017_1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/0024-3205(83)90047-4","volume":"32","author":"Simpkins J. W.","year":"1983","journal-title":"Life Sci."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm0509795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T17:48:21Z","timestamp":1706896101000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm0509795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,12]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2,1]]}},"alternative-id":["10.1021\/jm0509795"],"URL":"https:\/\/doi.org\/10.1021\/jm0509795","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,12]]}}}