{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:32:20Z","timestamp":1762673540966},"reference-count":11,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2006,6,1]]},"DOI":"10.1021\/jm060289g","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T04:38:57Z","timestamp":1149741537000},"page":"3444-3447","source":"Crossref","is-referenced-by-count":9,"title":["Structural Changes and Binding Characteristics of the Tetracycline-Repressor Binding Site on Induction"],"prefix":"10.1021","volume":"49","author":[{"given":"Harald","family":"Lanig","sequence":"first","affiliation":[{"name":"Computer-Chemie-Centrum der Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00e4gelsbachstrasse 25, 91052 Erlangen, Germany, and Fachbereich Chemie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf G.","family":"Othersen","sequence":"additional","affiliation":[{"name":"Computer-Chemie-Centrum der Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00e4gelsbachstrasse 25, 91052 Erlangen, Germany, and Fachbereich Chemie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Seidel","sequence":"additional","affiliation":[{"name":"Computer-Chemie-Centrum der Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00e4gelsbachstrasse 25, 91052 Erlangen, Germany, and Fachbereich Chemie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank R.","family":"Beierlein","sequence":"additional","affiliation":[{"name":"Computer-Chemie-Centrum der Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00e4gelsbachstrasse 25, 91052 Erlangen, Germany, and Fachbereich Chemie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Exner","sequence":"additional","affiliation":[{"name":"Computer-Chemie-Centrum der Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00e4gelsbachstrasse 25, 91052 Erlangen, Germany, and Fachbereich Chemie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Clark","sequence":"additional","affiliation":[{"name":"Computer-Chemie-Centrum der Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00e4gelsbachstrasse 25, 91052 Erlangen, Germany, and Fachbereich Chemie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"jm060289gb00001\/jm060289gb00001_1","first-page":"399","volume":"5","author":"Speer B. S.","year":"1992","journal-title":"Clin. Biol. Res."},{"key":"jm060289gb00002\/jm060289gb00002_1","first-page":"57","volume":"34","author":"Barza M.","year":"1977","journal-title":"Am. J. Hosp. Pharm."},{"key":"jm060289gb00003\/jm060289gb00003_1","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/1521-3773(20000616)39:12<2042::AID-ANIE2042>3.0.CO;2-C","volume":"39","author":"Saenger W.","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"jm060289gb00004\/jm060289gb00004_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1126\/science.8153629","volume":"264","author":"Hinrichs W.","year":"1994","journal-title":"Science"},{"key":"jm060289gb00005\/jm060289gb00005_1","first-page":"198","volume":"38","author":"Orth P.","year":"1999","journal-title":"Biochem."},{"key":"jm060289gb00006\/jm060289gb00006_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/jmbi.1998.2290","volume":"285","author":"Orth P.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"jm060289gb00007\/jm060289gb00007_1","first-page":"219","volume":"7","author":"Orth P.","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"jm060289gb00008\/jm060289gb00008_1","volume-title":"Molecular Dynamics Simulations of the Tetracycline-Repressor protein:\u2009 The Mechanism of Induction. J. Mol. Biol","author":"Lanig H.","year":"2006"},{"key":"jm060289gb00009\/jm060289gb00009_1","volume-title":"University of Utah","author":"Cheatham T. E., III.","year":"2003"},{"key":"jm060289gb00011\/jm060289gb00011_1","doi-asserted-by":"crossref","first-page":"10920","DOI":"10.1021\/bi001018p","volume":"39","author":"Scholz O.","year":"2000","journal-title":"Biochemistry"},{"key":"jm060289gb00012\/jm060289gb00012_1","unstructured":"Hinrichs, W.; Fenske, C. InTetracyclines in Biology, Chemistry andMedicine; Nelson, M.; Hillen, W.; Greenwald, R. A.; Eds.; Birkh\u00e4user Verlag:\u2009 Basel, Boston, Berlin, 2001; pp 107\u2212123."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm060289g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T20:26:56Z","timestamp":1632169616000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm060289g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,12]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,6,1]]}},"alternative-id":["10.1021\/jm060289g"],"URL":"https:\/\/doi.org\/10.1021\/jm060289g","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,12]]}}}